Presenter: Pejman Katiraei, DO

Title of Talk: Mycotoxins and Autism – The Missing Link

Abstract:

Children with autism have been found to have:

• 1) High oxidative stress
• 2) Metabolic and mitochondrial abnormalities
• 3) Elevated and abnormal maternal immune response during pregnancy
• 4) Abnormal systemic immunity with prevalence of mastocytosis
• 5) Abnormal mycobiomes, microbiomes and intestinal permeability
• 6) Gut immune activation with higher rates of inflammatory bowel disease
• 7) Microglial activation with resultant abnormalities in the amygdala and fear response
• 8) Abnormalities in neuroplasticity
• 9) Distortions in sensory pathways

According to the US EPA, 10-40% of US homes have mold (region dependent). A large body of scientific research can demonstrate that in-utero and early (first 2-3 years of life) exposure to molds and mold toxins may explain ALL of these abnormal physiological findings.

Very few parents have any awareness that there is mold in the home, and this exposure is often missed by practitioners. This presentation will demonstrate the above links and help practitioners understand why all children with autism should be screened for current or past mold exposure.

Presenter: Nancy O'Hara, MD, MPH, FAAP, FMAPS

Title of Talk: Demystifying Lyme & Co-Infections: Bringing It All Together: Testing and Pearls From the Day

Abstract:

Lyme disease and CO-infections, Borrelia, Bartonella, babesia and more are complex autoimmune diseases that require a multi-system approach. The presentation of these diseases can be chronic, subacute or acute as with PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome), and are among potential triggers for the immune dysregulation resulting in an abnormal autoimmune reaction and negative behavior, physical, and cognitive changes. Dr. O’Hara will discuss the latest research-guided testing in the assessment of these devastating but recoverable illnesses. She will also be pulling together all of the pearls that have been presented throughout the plenary session. Participants will learn the research-based functional medicine approach to the care, diagnosis and treatment of these children.

Presenter: Dr. Erica Peirson, ND

Title of Talk: Person-First Medicine: Actionable Means to Support the Health and Development of Children with Genetic Conditions

Abstract:

Children with genetic conditions like Down syndrome, Noonan syndrome, Dup15q syndrome, DiGeorge syndrome and others frequently experience diagnostic overshadowing in the clinical setting. This tendency of clinicians to attribute all health problems to their genetic condition only, leaving other coexisting conditions undiagnosed and untreated greatly decreases their quality of life, increases their suffering and contributes to their higher mortality rate. Applying the same functional medical principles used to help children with autism, ADHD, PANDAS and other neurodevelopmental conditions with these children can uncover actionable health issues that, when treated, can significantly optimize their overall health and development. Imbalances in gut health, methylation, neurotransmitters, oxidative stress, micronutrient deficiencies, immune system and mitochondrial function have all been uncovered in these children in my practice and have improved with the right supplementation and diet changes. Case reports will be presented to share the remarkable stories of several children and how they benefited from looking beyond their genetics.

Presenter: Dr Dana Johnson, PhD, MS

Title of Talk: Mind over motor: Understanding sensory motor differences and the impact of neurological "Noise" in the autistic population

Abstract:

Recent research on autism and movement differences point to neurological “noise” that impacts efficient and purposeful movement in the autistic population. These differences result in a disconnect between the brain and the body triggering the sympathetic nervous system and causing prolonged fight-or-flight responses. This presentation will discuss the current research on motor differences in autism including the sympathetic and parasympathetic responses to stress and how it applies to the nonspeaking and unreliably speaking autistic population. Specific ways to support the brain and body disconnect, regulation, and how to build purposeful motor skills including communication will be discussed. Nonspeakers who have contributed to the growing body of knowledge on motor differences and regulation will also be highlighted.

Presenter: Dr. Neuenschwander, MD, ABIM/AAPS, ABIHM, BCEM/AAPS, FMAPS

Title of Talk: HBOT and the Management of Chronic Infections

Abstract:

Hyperbaric oxygen therapy (HBOT) had originally been developed to treat decompression illnesses.  Since that time, multiple other indications for HBOT have emerged. Most of us are familiar with the uses of HBOT to manage localized infections that involve low oxygen states or with compromised blood flow. The classic examples of this would be gangrene and diabetic foot ulcers.  But what about using HBOT for systemic infections, both acute and chronic?  In this presentation, we will evaluate the mechanisms by which HBOT could be helpful for chronic infections.  In addition, we will examine the clinical evidence from the literature for efficacy of HBOT these situations. 

At the end of this lecture, participants should be well versed on the mechanisms of and evidence behind the use of HBOT for chronic infections like post treatment Lyme disease.

Presenter: Shannon Delaney, MD

Title of Talk: Neuropsychiatric symptoms related to lyme disease

Abstract:

In North America, Lyme disease (LD) is primarily caused by the spirochetal bacterium Borrelia burgdorferi, transmitted to humans by Ixodes species tick bites, at an estimated rate of 476,000 patients diagnosed per year.   Most acute cases of Lyme disease are effectively treated with antibiotics, but 10-20% of individuals may experience recurrent or persistent symptoms. Children may present with severe neuropsychiatric symptoms such as new onset OCD, anorexia, depression, anxiety or other sensory or behavioral problems; this condition is termed Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). This lecture focuses on the neuropsychiatric aspects of Lyme disease, as these are less widely recognized by physicians and often overlooked. Additionally, new tickborne illnesses are emerging, such as Borrelia miyamotoi; clinical data regarding this disease will be discussed. Broader education about the potential complexity, severity, and diverse manifestations of Lyme disease and other tick-borne diseases is needed.

Presenter: THEOHARIS C. THEOHARIDES, BA, MS, MPhil, PhD, MD, FAAAAI

Title of Talk: Brain mast cells and microglia lead to neuroinflammation and disrupt neuronal communication

Abstract:

Many large epidemiological studies have reported a strong association between Autism spectrum disorder (ASD) and atopic or neuroinflammatory conditions that involve the unique immune cells, mast cells and microglia. Using brains of deceased male children with ASD (n=7) and normal male children (3-14 yrs old) from the NIH NeuroBioBank, we had reported increased expression of the proinflammatory cytokine IL-1β and decreased levels of anti-inflammatory cytokine IL-38 in the amygdala, which are essential for our ability to feel emotions, sense fear and regulate behavior. We had also shown elevated levels of neurotensin, which stimulated cultured human microglia to secrete IL-1β We recently showed that the hippocampus, which is critical in social memory, had increased number of activated mast cells and microglia that contained and secreted large amounts of metalloproteinase-9 (MMP-9), which degrades chondroitin sulphate proteoglycans (CSPGs), a family of extracellular matrix molecules that serve as a key link between neurodevelopment and synaptic plasticity. We also conducted RNAseq profiling on postmortem human hippocampus and identified molecular pathways involved in extracellular matrix organization, neurodevelopment, synaptic regulation, and immune system signaling. We used qRT-PCR and Western blotting and confirmed increased expression of MMP9, but decreased expression of synaptic proteins PSD95, SYN1 and MEF2C. Our results point to alterations in immune system signaling, extracellular matrix molecule expression, microglia activation and expression of genes implicated in synaptic signaling and in ASD including SYN1 and MEF2C. Future studies will attempt to correlate such findings with ASD subtype and/or severity of symptoms to identify subgroups that may be amenable to targeted treatment approaches. Preliminary results indicate the ability of the natural flavonoid luteolin, which we had reported inhibits release of IL-1β from both mast cells and microglia, to also inhibit secretion of MMP9. Luteolin has been formulated in in softgel capsules with olive pomace oil for improved oral absorption (e.g. NeuroProtek®, NeuroProtek-Low Phenol) and in NeuroProtek-Low Phenol Liquid® that can be administered with a dropper under the tongue.

Presenter: Heather Tallman Ruhm, MD

Title of Talk: Total Body Load in Childhood Illness: A Higher-Order Systems Approach

Abstract:

Children’s lives reflect a perfect storm of events and exposures, past and present. The quality of our answers for addressing their needs reflect the quality of questions asked and “90% is in the history.” A deep look reveals varied networks of interdependent biologic systems - cells, tissues, pathways, organs, organelles andorganisms with dynamic roles and relationships – all influenced by the Total Body Load acquired in the modern world. Each child presents a developmental continuum with a unique profile – milestones met, missed, at risk of being missed, or in need of repair. None of us can be expert at every modality, test, interpretation, environmental factor, or the latest scientific understanding (or sort out all the misconceptions). CHIRP(TM) and FLIGHT(TM) are two on-going IRB approved research studies with a broad array of data, an “embarrassment of riches,” that allows us to document the complexity that today’s child presents and work toward a simplified collaborative model that results in Genuine Health Transformations (the GHT in FLIGHT). Using a large magnifying glass on a small sample size has already generated surprising insights and tools for clinical decision making. This presentation will provide a look at some of the early findings and how they might benefit an astute clinician.

Presenter: Thomas A. Moorcroft, DO

Title of Talk: Cutting edge treatments for lyme and co-infections in pediatrics

Abstract:

Lyme disease and tick-borne co-infections are becoming increasingly appreciated as causes of human disease and morbidity as well as triggers for Pediatric Acute-Onset Neuropsychiatric Syndrome (PANS/PANDAS. Once thought to be relatively rare, researchers are now finding that co-infection of ticks, such as Ixodes scapularis, occurs "more frequently than expected, resulting in enhanced human exposure to multiple infections that can cause more severe symptoms and sometimes make diagnosis more difficult" [Dunn 2014]. This knowledge has helped clinicians better define the often complex presentation of pediatric patients with acute onset behavioral changes and persistent tick-borne disease and opened new pathways for effective treatment and management of these patients.

Along with this greater understanding of the frequency of tick co-infection, other researchers have also looked for more effective treatment approaches for persistent co-infections. In this lecture, Dr. Moorcroft will review recent research breakthroughs and clinical applications in the utilization of both pharmacologic and botanical antimicrobials that have led to significant improvements in patient outcomes, decreased patient suffering and decreased burden of illness to society.

Presenter: Thomas A. Moorcroft, DO

Title of Talk: Utilizing methylene blue within chronic infections

Abstract:

Methylene blue, the first fully human-made medicine, was used as far back as 1891 as an anti-malarial drug. After falling out of favor due to side effects, such as blue urine and sclera, its use as an anti-malarial waned, religating its use to the treatment of methemoglobinemia and as a medical dye.

Interest in methylene blue has been revived in the past 20 years. It is a potent antioxidant, which has led to great interest in its potential uses in increasing longevity, making it a commonly discussed medication in the biohacking community. Known to have antiparasitic, antiviral and antibacterial properties, researchers have begun looking into its use in many infections, including viruses, Lyme disease and Bartonellosis.

In this lecture, Dr. Moorcroft will review the pharmacology of methylene blue and known applications as an antioxidant and antimicrobial. Specific focus will be placed upon the research and clinical use of this medication in addressing persister forms of infections, including Bartonella henselae. Having extensively used this medication in combination with both pharmaceutical and herbal antimicrobials in both adult and pediatric patients, Dr. Moorcroft will share clinical pearls for determining which patients are likely to respond best and how to most effectively combine this drug with other treatments for optimal patient outcomes.

Presenter: VICKI KOBLINER, MS RDN, FMAPS

Title of Talk: Foundations of Nutrition

Abstract:

Nutrition is the foundations of health and a comprehensive understanding and evaluation of diet quality is essential in order to effectively treat and support clients. Healthcare practitioners must be able to assess normal growth patterns as well as both macro and micronutrient status. In addition, it is equally important to identify what is necessary but inadequate in a clients diet to allow the body to perform optimally, as well as what they are getting in excess that contribute to disease and suboptimal function. Poor gut function, stress and chronic disease can deplete needed nutrients and further compromise health. Quantity, quality and composition of the diet provide opportunities for improving health, while therapeutic diets can have a powerful influence on healing.

Presenter: TAYLOR BEAN, ND, FMAPS

Title of Talk: Vaccine optimization and infant immunity

Abstract:

The concern and questions around vaccines is growing substantially around the globe. With this comes a lot of fear and concern about infections, vaccines, choices, traveling abroad and simply not being fully informed before making a decision around vaccinations. As one of very few ND’s in British Columbia to have obtained the Immunization Certification, Dr. Bean would like to present on some key areas around vaccinations that we as practitioners should know and what we can provide for our patients when they have questions. This should not be a topic of fear or anger but a topic that is honest, forthcoming and transparent.

In her office, she helps parents uncover the risks and susceptibility for their child in terms of contracting disease, educating them around infant immunity, ingredients in vaccines, what herd immunity is, the infections we vaccinate against, and how we can mitigate potential adverse reactions with vaccines.

Practitioners should know what resources to offer their patients who have questions around vaccines along with knowing where they can go for current and reputable information. From simply knowing how to locate a vaccine insert, utilizing annual surveillance reports from the CDC, understanding how adjuvants and lastly understanding infant physiology as it pertains to vaccination (immunology).

Presenter: LIZ MUMPER, MD, FAAP FMAPS

Title of Talk: Practical experience on the prevention of autism

Abstract:

Can awareness of medical problems common in autism and emerging data about pathologic pathways in autism lead to prevention of some autism cases? This is the question Dr. Mumper asked in 2005, which lead to an ongoing autism prevention project at Advocates for Children, her general pediatric primary care practice. After 16 years of data collection, the answer seems to be "yes."

In this lecture, Dr. Mumper will discuss how the medical abnormalities seen in patients with autism informed practice recommendations to families born into her practice. She will discuss why it became a priority at Advocates for Children to promote optimal gut flora diversity in the first thousand days of life. She will discuss how optimal Vitamin D recommendations, promotion of prolonged breastfeeding, limitation of antibiotic prescriptions, constraints on acetaminophen use, and use of a modified vaccine schedule may have impacted lower rates of autism, ear infections, allergies and developmental delays seen in her practice compared to background rates.

Presenter: MYRIAH HINCHEY, ND

Presentation Title: The Interplay Between COVID and Lyme

Research Focus: Key similarities and discrepancies in the diagnosis and management of SARS-CoV-2 and Borrelia

Abstract:

The COVID pandemic has greatly impacted the way medical professionals have encountered and can assess Lyme disease and tick-borne illness (TBI) over the past three years. Because of the hyperfocus on SARS-CoV-2 and its variants, many severe illnesses have gone undiagnosed and mismanaged. This has led to a greater incidence of complications from these TBI1, creating a silent pandemic of chronic infectious illness. Not only are those recently infected with Borrelia bugdorferi at a higher risk of being undiagnosed in a timely manner, the infection itself presents a greater risk for complications of SARS-CoV-2, should they also become infected with COVID. Newer research is finding that increased levels of Borrelia-specific IgG correlate with greater severity of COVID symptoms and increased risk of hospitalization.2 The link between Borrelia and SARS-CoV-2 is becoming increasingly apparent, and this lecture aims to shed light on the precise mechanisms of action these two infectious agents affect.

Cytokine pathways altered by Lyme disease are well documented34, and are nearly identical to those affected by COVID infection. A significant increase in the expression of the following biomarkers is noted in both Lyme and COVID patients: ACE-2, AKT-1, CD44v6, IL-4, MMP-9, α-SMA, Sphingosine-1, and TGF-β15. Practitioners familiar with anti-inflammatory and immune modulating protocols may have success addressing these pathways for patients experiencing exacerbations of symptoms of Lyme, COVID, or both.

Presenter: RICHARD FRYE, MD, PHD, FMAPS

Presentation Title: The Influence of the Environment on Neurodevelopment: Mechanisms of Disease and Resilience

Abstract:

Accumulating evidence suggests that many neurodevelopmental disorders start prenatally with a strong influence of the maternal environment. Several prenatal factors associated with neurodevelopmental disorders, including toxins, nutrients and inflammation can affect metabolism, including mitochondrial function, resulting in mitochondrial dysfunction, oxidative stress and immune dysregulation that may be long lasting, continuing well into childhood. Many times, these effects may be subclinical and may not be obvious in infancy and may predispose children to neurodevelopmental regression resulting from an external toxin or inflammatory trigger. On the other side, many prenatal factors can decrease the risk of neurodevelopmental disorders and provide resilience. For example, prenatal nutrients, such as folate, can reduce the risk of neurodevelopmental disorders when supplemented and other prenatal nutrients such as vitamin D and zinc can increase the risk of neurodevelopmental disorders when deficient. Abnormalities in metabolism of these nutrients such as polymorphisms and deficiencies in transport of nutrients across the placenta may reduce the availability of these nutrients to the fetus, thereby decreasing resilience to inflammation, toxins, or exposures to medications. The evidence for these abnormalities and potential methods for intervention will be discussed.

Presenter: MYRIAH HINCHEY, ND

Presentation Title: A deep dive into the pathophysiology of Borreliosis and Babesiosis and the MOAs of Herbal Intervention.

Abstract:

The field of tick-borne disease (TBD) is complex and ever-evolving. With recent research providing measurable evidence of how Herbal and Naturopathic medical interventions impact the initial infection and progression of TBD, functional medicine clinicians have a tremendous opportunity to change the course of a patient’s journey with Lyme disease and co-infections through individualized care in both the acute and chronic stages of illness. This lecture is an overview of the pathophysiology of Lyme disease causing species of Borrelia as well as Babesia. It includes a deep dive into the biochemical pathways involved in both acute and chronic infection, understanding the mechanism of action (MOA) of studied herbal interventions, a four-pronged approach to treatment, and naturopathic interventions to support healing at every step.

A complex network of functional deficiencies needs to be addressed to prepare each patient for an optimal therapeutic response to a tick-borne infection. Individual constitution, genetics, nutrient deficiencies, gastrointestinal dysbiosis, food sensitivities, heavy metal and toxin burden, immune imbalance, mycotoxin illness, endocrine dysfunction, as well as pre-existing biofilm status, contributes to an inflammatory milieu, which provides a safe harbor for infections. A major obstacle to achieving treatment success is the suppressive effect of inflammation on critical functions, including immunity. Research is providing a more in-depth understanding of the mechanisms driving chronic inflammation, pointing to new therapeutic targets and interventions.

Substantial evidence points to galectin-3 (Gal-3), a carbohydrate binding protein, as an important signaling molecule triggering proinflammatory and profibrotic pathways relevant in tick-borne illness. Though Gal-3 plays an essential role in the body’s initial recognition and response to infection, at elevated levels, it fuels chronic inflammation, fibrosis, and immune suppression. Gal-3 forms an adhesive framework for biofilm formation via its ability to form “lattice/scaffolding” structures by self-polymerizing and crosslinking to glycoproteins and glycolipids. It binds with immune cell surface receptors and antigenic sites on infectious agents, interrupting the communication and activation of critical immune responses and immune surveillance. Gal-3 also interacts with pathogenic organisms to enable adhesion and penetration within tissues to establish biofilms. Research shows that a natural Gal-3 inhibitor, modified citrus pectin, disables Gal-3-orchestrated immune suppression and stimulates NK cell production, enabling a robust immune response while controlling inflammation.

Successful antimicrobial interventions require preparation to strengthen and support the body’s innate detoxification systems, correct deficiencies, and create a pathogen-resistant environment, all of which promotes a balanced and robust immune response. Additionally, it is imperative to understand the pathophysiological process in which the organisms hijack the immune system allowing them not only to survive, but thrive while ravishing the human body. Once a practitioner has an understanding of this process, along with understanding the mechanism of action of each herb, it is easy to put together an intelligent treatment protocol to intervene at each pathophysiological process and begin to heal the body from TBD while killing the organisms. In this presentation, Myriah Hinchey, N.D., a recognized clinician with success in treating complex chronic tick-borne illnesses for over a decade, will present her multilayered approach to individualized treatment.

Learning Objectives & Lecture Schedule

• Why many treatments fail (1 min)
  • Shifting focus from just killing pathogens to making the body inhospitable to infection and healing the patient
• Understanding the pathophysiology of Lyme infection (20 minutes)
  • Transmission of infection
  • Acute infection
  • Chronic infection
  • MOA of herbs and how they intervene
• How co-infections differ (10 minutes)
  • Babesia pathophysiology
• A comprehensive approach to treatment (12 minutes)
  • Decrease inflammation: restore GI integrity
  • Restore immune function: protect RBCs and increase nitric oxide
  • Detoxify: naturopathic supportive therapies
  • Kill the pathogen: herbal antibiotics
• The role of Gal-3 in Lyme infection (3 minutes)
• Modified citrus pectin: natural Gal-3 inhibitor and comprehensive Lyme intervention (5 minutes)
• Pediatric Case studies (5 mins)

Presenter: TERESA HOLLER, MS, PA-C

Presentation Title: Addressing Lyme in Your Practice

Abstract:

This presentation is designed to be a stand-alone tool for practitioners to confidently initiate effective treatment for PANS/PANDAS and Lyme borreliosis. Case studies will be utilized to present the data in an easy-to-digest manner, and participants will leave the presentation with the knowledge of a simple, safe, and effective treatment option that they can implement immediately in their practice.

Upon completion of Teresa Holler's presentation, participants will achieve the following:

• Awareness of recent studies confirming a link between PANS/PANDAS and Lyme borreliosis
• Understanding of the pleomorphic nature of Lyme borrelia
• Awareness of clinical studies comparing the antibiotic doxycycline to herbal products
• Understanding of the effectiveness of both prescription and herbal antimicrobials on persister forms of Lyme borrelia

Presenter: NANCY O'HARA, MD, MPH, FAAP, FMAPS

Presentation Title: Demystifying PANS/PANDAS: A Functional Medicine Guide on Basal Ganglia Encephalitis

Abstract:

PANS & PANDAS are complex autoimmune diseases that require a multi-system approach. PANDAS (Pediatric Autoimmune Neuropsychiatric Disorder Associated with Strep) involves antibodies from a strep infection reacting with brain tissue (specifically the basal ganglia in the brain) and triggering an abrupt onset of immune dysregulation and movement, learning and behavioral problems including OCD, anxiety and tics. With PANS (Pediatric Acute-Onset Neuropsychiatric Syndrome), other infectious etiologies besides strep (yeast, viruses, other bacteria, parasites), toxic exposures, and metabolic abnormalities are among other potential triggers for the immune dysregulation resulting in an abnormal autoimmune reaction and negative behavior, physical, and cognitive changes. Dr. O’Hara will discuss the latest research in the assessment and treatment of these devastating but recoverable illnesses in the context of several illustrative case studies.  Participants will learn the research-based functional medicine approach to the care, diagnosis and treatment of these children.

• The participant will be able to understand the assessment, diagnosis and treatment of PANS, PANDAS and Basal Ganglia Encephalitis through Case Study presentations
• The participant will be able to differentiate causes of anxiety, OCD and tics, as it relates to autoimmune encephalitis.
• The participant will be able to define the triad of treatments for PANS and PANDAS.

Presenter: Darin Ingels, ND, FAAEM, FMAPS

Presentation Title: Low dose immunotherapy: A Novel Treatment for Tick-Borne Disease

Abstract:

Lyme disease and coinfections can often trigger autoimmune reactions that can cause gastrointestinal, neurological and connective tissue disorders. Few therapies exist to modulate the immune response and downregulate overexpression toward autoimmunity. Low dose immunotherapy (LDI) is a novel new approach to accomplish that goal. LDI is a nosode therapy that evolved from low dose allergy therapy (LDA), developed by Dr. Len McKewen more than 60 years ago. Dr. Ty Vincent developed LDI almost 9 years ago after recognizing that the immune mechanisms involved with allergies was not dissimilar to how the immune system reacted to various microbes. Research shows that microbes, including Lyme, can upregulate Th2 pathways and produce antibodies that cross-react with several proteins on our cell surfaces causing inflammation and symptoms. LDI utilizes diluted inactivated organisms mixed with beta glucuronidase to help modulate Treg cells and downregulate Th2 activity. Patient symptoms often improve after using LDI. LDI is a novel therapy to help modulate autoimmune mechanism triggered by Lyme or coinfections. Other conventional immune modulating therapies, such as IVIG are difficult to get insurance reimbursement, expensive and come with potential risks and side effects. There are currently no other oral treatments that specifically address microbe-induced autoimmunity. This safe, cost-effective therapy can be used with any Lyme patient, regardless of age or health condition.

Objectives:

• Be able to describe the underlying mechanisms of LDI and how it influences the immune system
• Recognize which pathogens are associated with specific autoimmune diseases
• Be able to manage patient responses to LDI and make appropriate adjustments to treatment

Presenter: Darin Ingels, ND, FAAEM, FMAPS

Presentation Title: Natural Treatment of Common Childhood Infections

Abstract:

Acute and chronic infections are common reasons children are brought to see their pediatrician as well as visits to the emergency department. In this lecture, Dr. Ingels will explore the underlying etiology of what factors precipitate these infections, including otitis media, sinusitis, urinary tract infections, bronchitis, diarrhea, impetigo and MRSA. Several nutritional and herbal therapies can be utilized to help support the child’s immune system and fight infection without the same risks of conventional antibiotic therapy. Dr. Ingels will review how to manage underlying foundational terrain disruptors and specific treatments for each type of infection.

Objectives:

• Be able to describe root causes of acute and chronic infections.
• Identify natural treatments appropriate for each type of infection and proper dosing.
• Understand contraindications for nutritional and herbal therapies and when referral is appropriate.

Presenter: LIZ MUMPER, MD, FAAP FMAPS

Case Presentations

Abstract:

In a series of 3 cases, Dr. Mumper will demonstrate how the use of innovative medical interventions lead to clinical success in two of the cases. In the third case, brain surgery to remove seizure foci was considered because classic treatments had failed to adequately control the patient’s seizures.

The first case will explore the clinical indications and specifics of antifungal therapy to impact behavior in children with autism, especially for self-injurious behavior. The second case explores the successful use of amantadine for obsessive compulsive behaviors. The third case is the patient that motivated Dr. Mumper to leave her academic position as Director of Pediatric Education at a family practice residency program to start a solo practice to address the needs of children affected by the autism epidemic. The patient regressed into autism after his 15-month check-up. Despite Dr. Mumper’s best efforts to apply emerging science to his neurodevelopmental problems over the past 22 years, he has little language today and his seizures are challenging to control.

Presenter: Aunna Herbst, ND, DO

Presentation Title: PDD, ODD and Bedwetting - Utilizing Genomics as a guide for direct care and successful outcomes:

Abstract:

Epigenetics and genetics go hand in hand. Our various proteins and enzymes are determined by our genetics -which relates to our metabolic needs. Epigenetics means "on top of genetics" and relates to how we can modulate the genetic code we are born with and how our interactions with our world affect our genetic expression. This lecture will demonstrate, by case review, how utilization of targeted genomic information can help individualize treatment and improve outcomes. Talk will be reference-based, and will focus on clinical treatments from the lens of a primary care, functional medicine, physician, and will be accessible to both experienced and novice healthcare providers.

Presenter: Lindsey Wells, ND, FMAPS

Presentation Title: Best herbals for lyme and lyme co-infections

Abstract:

It is estimated that about a third of patients treated for Lyme Disease with antibiotics per CDC guidelines continue to experience persistent symptoms post treatment. There are many reasons as to why this may occur, including the limitation of antibiotics to effectively eradicate these infections. This lecture will highlight the importance of including botanical herbs in treatment protocols due to their potent antimicrobial actions against various morphological forms, ability to support the immune system, and improve symptoms. Various herbals will be discussed in detail so one will feel confident implementing herbs for more successful treatment outcomes in clinical practice.

Presenter: Dr. Debby Hamilton, MD, MPH

Title of Talk: Supportive Clinical Treatment for Children with PANS/PANDAS

Abstract:

PANS/PANDAS are complex autoimmune diseases that cause a significant impact on children and their parents. Severe behavioral and mood issues that include regression in development, anxiety, and OCD disrupt children’s lives. Comprehensive treatment approaches are needed including supportive nutraceuticals. These nutraceuticals include anti-microbial herbs and adaptogenic and calming herbs. Inflammation and immune dysregulation play a role in the development of PANS/PANDAS so modulating and balancing the immune system plays a key role in addition to targeting the infections. This lecture will focus on supplemental treatment for PANS/PANDAS and will include specific recommendations for supportive treatment.

Presenter: JAMES NEUENSCHWANDER, MD, FMAPS & MARIA GAHRY, DNP, RN, FNP, FMAPS

Title of Talk: BIOCHEMICAL BASIS OF THE INTEGRATIVE APPROACH

Abstract:

Buckle up! This presentation is a 90-minute foray into the biochemistry behind the integrative/biomedical approach. We will cover the basics of methylation and the methylation/sulfation connection. The principles and importance of the gut-brain-immune triad. The impact of gut health on the entirety of health. We will dive into mitochondrial function (it is far more than the powerhouse of the cell) and the importance of the cell danger response. Finally, we will look at the impact of toxins on the function of our kids’ physiology. By the time we are done, you will have a firm grasp of the biochemical basis of the biomedical approach.

Presenter: MICHAEL ELICE, MD, FMAPS

Title of Talk: ASSESSMENT IN CLINICAL PEDIATRICS

Abstract:

In this hour, we will evaluate the sometimes confusing landscape of assessing the kids we see. What are the advantages of the various tests commonly used by integrative practitioners? How can we more efficiently use our traditional labs? What are some of the shortcomings of some of our integrative tests and how do we most efficiently use our client’s resources to get the information we need.

Presenter: DANE FLIEDNER, M.D., MPH, FAAP, IFMCP, FMAPS, ABOIHM

Title of Talk: CLINICAL IMPLEMENTATION OF THE INTEGRATIVE APPROACH

Abstract:

So, you have all this information; how do you apply it in your office. In this presentation we will look at the ways to integrate the biomedical approach into your practice. How to identify patients that would benefit from this approach. How to apply the knowledge you have obtained to your practice starting Monday morning.

Presenter: JAMES NEUENSCHWANDER, MD, ABIM/AAPS, ABIHM, BCEM/AAPS, FMAPS

Title of Talk: FOUNDATIONS OF BIOMEDICAL THINKING

Abstract:

Frequently, we are not aware of our thought process; and this can get in the way of appropriately managing our patients. In this presentation, we will identify the key differences in the thought process behind the biomedical approach versus our standard medical model. Understanding the interconnectedness of our systems and how manipulating one thing in one system can impact the entire body. We will investigate how to change the thought process when we approach our patients. As Dr. Sid Baker once said, “if you are having problems answering a question about how to treat a patient, maybe you are asking the wrong question.”

Presenter: Dan Rossignol, MD, FAAFP, FMAPS

Title of Talk: A review of new research findings in autism spectrum disorders

Abstract:

Dr. Rossignol will present recent studies that have been published in the last year on autism. From over 10,000 published articles, the most relevant studies will be discussed. The reviewed studies include medical comorbidities of autism, diets, IVIG, and new treatments including nutritional supplements and medications.

Presenter: DANE FLIEDNER, M.D., MPH, FAAP, IFMCP, FMAPS, ABOIHM

CASE PRESENTATIONS

Abstract:

"Although the rates of neurodevelopmental disorders has grown exponentially over the last decades, there is another, more insidious and often more devastating group of conditions that are becoming increasingly prevalent. Neuroimmunologic disorders have exploded in frequency, especially in light of Covid-19’s long term sequelae. These cases will highlight some of the disparate presentations of neuro-immune disorders, along with some discussion of commonly associated comorbidities seen in this group of patients."

Presenter: DAVID DORNFELD, DO, FMAPS

CASE PRESENTATIONS

Abstract:

When looking at ways to help children and adults with Autism Spectrum disorders, one needs to look at the environmental triggers and how it influences outcomes and may delay progress of the children. It is my hope to be able to demonstrate through two or three of my patient cases, a logical pathway of evaluating patients with PANDAS, PANS, Babesia with lyme disease and Crohn's disease, and help return the child to a more neuro-typical presentation. I try to utilize detoxification and hyperbaric therapies when needed in many of my ASD patients and will share these techniques and I review these cases.

Presenter: DAN ROSSIGNOL, MD, FAAFP, FMAPS

Title of Talk: LATEST RESEARCH IN AUTISM SPECTRUM DISORDER

Abstract:

Dr. Rossignol will present recent studies that have been published in the last year on autism. From over 10,000 published articles, the most relevant studies will be discussed. The reviewed studies include medical comorbidities of autism, diets, IVIG, and new treatments including nutritional supplements and medications.

Presenter: NAILA GOLDENBERG, MD

Title of Talk: MOLD TOXITICY, AUTISM, MITOCHONDRIAL DYSFUNCTION, EDS, POTS, CHARCOT-MARIE-TOOTH, IMMUNODEFICIENCY, WHO DEVELOPED SECONDARY ADRENAL INSUFFICIENCY DUE TO FREQUENT STEROIDS INJECTIONS FOR IVIG INFUSIONS

Abstract:

Insulin pump with Solu-Cortef is known to be utilized in patients with Adrenal Insufficiency due to CAH, but can be a great option in patients with poorly controlled secondary adrenal insufficiency.

This case report will showcase how to improve the quality of life by medically addressing core issues. Young male with history of mold toxicity, autism, mitochondrial dysfunction, EDS, POTS, Charcot-Marie-Tooth, immunodeficiency, develops secondary adrenal insufficiency due to frequent steroids injections for IVIG infusions . Clinically was Cushingoid, with BMI 26.36 kg/m², 97th percentile by weight and 80th percentile by height. Patient was frequently in ER with Adrenal crisis, utilizing 100+ mg of Hydrocortisone/Solu-Cortef per day and gained 50 lbs. over the previous year and stopped growing. 

Presenter: SONIA MCGOWIN, DC

Title of Talk: UNRAVELING THE NEUROBIOLOGICAL IMPLICATIONS OF ORAL RESTRICTIONS ON SPEECH, NERVOUS SYSTEM & MOTOR DEVELOPMENT

Abstract:

There is an intricate relationship between oral restrictions, such as tongue and lip ties and their profound effects on the neurobiology of speech, nervous system and motor development.

Tongue ties are congenital anomalies where the frenulum beneath the tongue is abnormally short or tight, restricting the tongue’s range of motion. While their presence is not uncommon, their consequences can extend far beyond simple anatomical differences. This presentation will delve into the multifaceted ways in which oral restrictions influence development.

First, we will explore the crucial role of the tongue in speech production and articulation. Oral restrictions can significantly impede the development of clear and intelligible speech, affecting communication skills from an early age. We will examine the specific speech challenges that individuals with tongue ties may face, as well as potential interventions and therapies to mitigate these issues.

Second, we will investigate the intricate connection between the tongue, the nervous system, and overall neurological development. The tongue plays a pivotal role in oral sensory perception, gross and fine and motor coordination, making it a vital component in early neural pathways. We will discuss how tongue ties might disrupt these pathways, potentially leading to broader developmental issues, such as sensory processing disorders and learning difficulties.

Lastly, we will shed light on the impact of tongue ties on gross motor development. Proper tongue mobility is essential for fundamental activities such as breastfeeding, swallowing, breathing and facial muscle coordination. We will delve into the potential repercussions of impaired tongue function on these processes and their consequences for overall motor development in children.

Through a comprehensive examination of these interconnected facets, this presentation aims to enhance our understanding of the impact of tongue ties on human development and highlight the importance of early assessment and intervention.

Presenter: RICHARD FRYE, MD, PHD, FMAPS

Title of Talk: LOCKED-IN NETWORK SYNDROME: FUNCTIONAL RESTING STATE MRI REVEALS INTACT FUNCTIONAL LANGUAGE NETWORKS IN MINIMALLY VERBAL CHILDREN WITH AUTISM SPECTRUM DISORDER

Abstract:

Richard E Frye ¹,* Patrick J. McCarty ² and Varina L. Boerwinkle ^3
1Autism Discovery and Treatment Foundations, Phoenix AZ
² Tulane University School of Medicine, New Orleans, LA
³ University of North Carolina, Chapel Hill, NC

Resting state functional magnetic resonance imaging (rs-fMRI) has the potential to investigate abnormalities in brain network structure and connectivity on an individual level in neurodevelopmental disorders such as autism spectrum disorder (ASD), paving the way to use this technology for a personalized, precision medicine approach to diagnosis and treatment. Using a case-control design, we compared five patients with severe regressive type ASD to five patients with temporal lobe epilepsy (TLE) to examine the association between brain network characteristics and diagnosis. All children with ASD and TLE demonstrated intact motor, language, and frontoparietal (FP) networks. However, aberrant networks not typically seen in the typical brain were also found. These aberrant networks were located in the motor (40%), language (80%), and FP (100%) regions in children with ASD, while children with TLE only presented with aberrant networks in the motor (40%) and language (20%) regions in addition to identified seizure onset zones. Fisher’s exact test indicated a significant relationship between aberrant FP networks and diagnosis (p = .008), with ASD and atypical FP networks co-occurring more frequently than expected by chance. Despite severe cognitive delays, children with regressive type ASD may demonstrate intact typical cortical network activation despite an inability to use these cognitive facilities. The functions of these intact cognitive networks may not be fully expressed, potentially because aberrant networks interfere with their long-range signaling, thus creating a unique "locked-in network" syndrome.

Presenter: ELIZABETH BONKER

Title of Talk: FIGHT-OR-FLIGHT NO MORE: USING HRV TO GET NONSPEAKERS ON THE RIGHT VAGAL BRANCH

Abstract:

This presentation will be a first-person case study of how natural interventions were used guided by a scientist over a two-year period to move Heart Rate Variability (HRV) data into a "normal" range giving the nonspeaking participant relief from living in fight-or-flight mode. HRV recordings taken before and after interventions helped determine which were most effective at different points in the treatment cycle.

Presenter will discuss interventions including concentrated CBD oils, meditation, auditory tones, grounding devices, deep breathing, and exercise. Particular CBD oils were selected and given at concentrated doses at particular intervals based on the HRV data to mimic the effects of the drug suramin.

Presenter will discuss applicable research including Dr. Robert Naviaux's studies regarding Cell Danger Response and Dr. Stephen Porges’ Polyvagal Theory.

Pre-HRV intervention, Presenter experienced constant anxiety and frequent self-injurious behavior. Post-HRV intervention, she graduated valedictorian from Rollins College. She believes the vast majority of nonspeakers with autism live in fight-or-flight mode and that a protocol could be developed to help them move to safe mode.

She hopes this presentation will stimulate further study and collaboration between doctors and nonspeakers to develop an HRV protocol for nonspeakers to live calmer, more productive lives where they can more easily communicate.

Elizabeth Bonker is the Executive Director of Communication 4 ALL (C4A), a nonprofit with the mission to gain communication for the estimated 31 million nonspeakers with autism worldwide. Elizabeth types to communicate. Her decade of advocacy work includes a book, I Am in Here; TEDMED Talk in the Kennedy Center, and a music album. In May 2022, Elizabeth’s valedictorian commencement address at Rollins College went viral with more than 4 billion media impressions creating momentum for her mission. Elizabeth is a member of Autism Society’s Council of Advisors and Justice Center Task Force

Presenter: JOHN GAITANIS, MD

Title of Talk: APRAXIA, APHASIA, ABULIA? WHICH PATIENTS WILL BENEFIT FROM SPELLED COMMUNICATION

Abstract:

Apraxia, Aphasia, Abulia? Which patients will benefit from Spelled Communication?

Identifying patients who are appropriate candidates for Spelled Communication can be challenging.

Knowing the best treatment approach begins with characterizing the basis of speech impairment.

The clinician must distinguish between language versus motor barriers. Language impairment (aphasia) can take multiple forms and is sometimes associated with structural abnormalities or a rare form of epilepsy (Landau-Kleffner Syndrome). When motor function is the culprit, motor planning and sequencing(apraxia) must be distinguished from motor initiation (abulia), although the two can co-exist in the same patient. A detailed clinical assessment will identify the specific nature of the language impairment. This knowledge is essential for the treating therapist and will readily identify patients who are appropriate candidates for spelled communica1on.

Presenter: NANCY O'HARA, MD, MPH, FAAP, FMAPS

Title of Talk: THE NEUROBIOLOGY OF SPEECH REGRESSION AND POST-ACUTE INFECTION SYNDROMES (PAIS):
Why Did My Child Stop Talking and What Can I Do?

Abstract:

PAIS, PANS & PANDAS are complex autoimmune diseases that require a multi-system approach. Multiple studies demonstrate that speech disfluency (including tics and baby talk), selective mutism and stuttering can be seen with Autoimmune or Basal Ganglia Encephalitis. Almost 55% of caregivers support a link between infections, including strep, viruses, mycoplasma, lyme and co-infections, and speech dysfluency. These changes in communication can be reversed with a functional medicine 3-pronged approach of immune modulation, appropriate antimicrobials and symptoms support. Dr. O’Hara will discuss the latest research in the assessment and treatment of these devastating but recoverable illnesses in the context of several illustrative case studies and review of the current literature.  Participants will learn the research-based functional medicine approach to the care, diagnosis and treatment of these children with an abrupt onset of speech regression.

• The participant will be able to understand the assessment, diagnosis and treatment of speech regression and disfluency in PAIS and Basal Ganglia Encephalitis through literature review and case study presentations
• The participant will be able to differentiate causes and pathophysiology of speech regression in autoimmune encephalitis.
• The participant will be able to define the treatments for such PAIS-induced regression in communication.

Presenter: VICKI KOBLINER, MS RDN, FMAPS

Title of Talk: PERINATAL NUTRITION AND SPEECH AND LANGUAGE DEVELOPMENT: THE ROLE OF DIET, LIFESTYLE AND NUTRITION SUPPORT

Abstract:

Appropriate development of speech and language in children requires a combination of proper neurologic and mechanical function, both of which require nutritional cofactors. Nutrition and lifestyle interventions from preconception through a child’s first years can impact speech and language development and modify risks. Disparate factors such as nutrient inadequacies, breast vs. formula feeding, as well as types of formulas, exposure to environmental toxins through diet, and maternal levels of stress hormone and medication use have all been associated with language delays in children. Addressing these issues during preconception through the first years of life may reduce the risk.

Presenter: EBONI CORNISH, MD Board Member ILADS, Functional Medicine Director AMEN Clinic

Title of Talk: Parasitic Involvement in PANS including Toxoplasma Gondii. A missing link

Abstract:

Toxoplasma gondii, a protozoan parasite, has long been known to infect a significant portion of the global population. While the majority of infections are asymptomatic and benign, mounting evidence suggests that Toxoplasma infection, particularly in its chronic form, may have subtle yet significant effects on the human brain, leading to late-stage neurological, cognitive, and psychiatric consequences in adults and children . This presentation reviews the current state of knowledge regarding the relationship between Toxoplasma infection and late-stage neurological, cognitive, and psychiatric impacts, highlighting the potential mechanisms, brain scan abnormalities and PANS symptoms

Emerging evidence suggests that chronic Toxoplasma infection among other parasites may lead to cognitive deficits, including impaired memory, decreased processing speed, and reduced executive function. These cognitive changes may be more pronounced in infected individuals with psychiatric comorbidities, such as schizophrenia, further complicating their management.

The link between Toxoplasma infection and psychiatric disorders, particularly PANS, has been the subject of intense investigation. Several studies have reported a higher prevalence of Toxoplasma antibodies in individuals with schizophrenia, raising questions about the potential role of this parasite in the development of psychiatric illness. While causality remains elusive, these findings underscore the need for further research into the complex interplay between Toxoplasma and psychiatric health. We will review a pediatric case study on Toxoplasma Gondii and gut parasites.

Presenter: KRISHNA DONIPARTHI, MD, FMAPS

Title of Talk: The Intersection of Autism Spectrum Disorder (ASD), the Gut Microbiome, and Plasmalogens

Abstract:

The intersection of autism spectrum disorder (ASD), the gut microbiome, and plasmalogens presents a captivating yet intricate domain of investigation with potential implications for comprehending the origins and management of ASD. Although each element has been studied separately, emerging evidence suggests connections among them.

Studies have revealed that individuals with ASD often exhibit differences in their gut microbiome composition compared to neurotypical individuals. This dysbiosis may contribute to the gastrointestinal issues frequently observed in those with ASD and can influence neurodevelopment and behavior through the gut-brain axis.

Research has linked lower levels of plasmalogens in individuals with ASD to various neurological functions relevant to ASD pathology, including neuronal development, synaptic function, and inflammation regulation.

While direct research on the connection between plasmalogens and the gut microbiome in ASD is limited, plausible mechanisms exist. The gut microbiome's influence on lipid metabolism may impact plasmalogen synthesis or turnover. Additionally, changes in gut microbial composition can lead to inflammation and oxidative stress, which may further affect plasmalogen levels.

Investigating how the gut microbiome, plasmalogens, and ASD intersect could provide valuable insights into ASD mechanisms. Therapeutic interventions targeting the gut microbiome, such as grapefruit extract, probiotics, dietary modifications, plasmalogens, and other natural substrates, may hold the potential to modulate plasmalogen levels and improve outcomes in ASD. As research progresses, understanding the relationships among ASD, the gut microbiome, and plasmalogens may offer novel strategies for managing ASD and enhancing the well-being of affected individuals.

Presenter: JOHN GAITANIS, MD

Title of Talk:SUDDEN UNEXPLAINED DEATH IN EPILEPSY PATIENTS (SUDEP): WHAT CAN BE DONE TO PROTECT OUR KIDS

Abstract:

Sudden Unexplained Death in Epilepsy Patients (SUDEP): What can be done to protect our kids?

The term SUDEP refers to deaths in people with epilepsy that are not caused by injury, drowning, or other known causes. It is estimated that there are about 1.16 cases of SUDEP each year for every 1,000 people with epilepsy. Knowledge of the risk factors and potential triggers is a first step towards prevention. Lowering the risk for SUDEP involves improving seizure control, avoiding seizure triggers, beUer sleep, stress reduction, and seizure monitoring both inside and outside the home. Training caregivers on seizure management and having a seizure ac1on plan also reduce risk. It is important to have a conversation with the treating physician about SUDEP and to discuss ways to reduce its likelihood. Specific considerations for children and young adults with ASD with be reviewed since sleep, stress reduction, and seizure control can be particularly difficult in this population.

Presenter: KAT JOHNSON, DNP, ARNP, FNP-BC, C-PMHS, PMHNP-BE

Title of Talk:Autism, ADHD, and Ehlers-Danlos Syndrome/Hypermobility Syndrome Disorders (EDS/HSD): Evaluation, Diagnosis, and Treatment Modalities for Co-Occurring Challenges in Neurodevelopmental Pediatrics

Abstract:

Content will contain: 

• Current/growing prevalence of autism, ADHD, and EDS/HSD
• Overlapping symptoms, co-occurrence, impacts to quality of life
• Review of evaluation tools, diagnostic criteria, Beighton Scale, etc
• Treatment options (referrals such as Cardiology, PT, OT, Speech; conservative options such as compression wear, salt intake, hydration; supplements...still exploring, but NAC, mitochondrial supplements; and medications such as atomoxetine, Adderall XR/Vyvanse/Dexedrine for ADHD/fatigue; pain management with LDN, duloxetine, etc).
• I need to do more research to support enough to present this, but we already recommend red light/infrared therapy for pain/inflammation,  and are looking into the application of HBOT for dysautonomia/POTS.

Presenter: KAT JOHNSON, DNP, ARNP, FNP-BC, C-PMHS, PMHNP-BE

Title of Talk:Autism, ADHD, and Ehlers-Danlos Syndrome/Hypermobility Syndrome Disorders (EDS/HSD): Evaluation, Diagnosis, and Treatment Modalities for Co-Occurring Challenges in Neurodevelopmental Pediatrics

Abstract:

Content will contain: 

• 1. Current/growing prevalence of autism, ADHD, and EDS/HSD
• 2. Overlapping symptoms, co-occurrence, impacts to quality of life
• 3. Review of evaluation tools, diagnostic criteria, Beighton Scale, etc
• 4. Treatment options (referrals such as Cardiology, PT, OT, Speech; conservative options such as compression wear, salt intake, hydration; supplements...still exploring, but NAC, mitochondrial supplements; and medications such as atomoxetine, Adderall XR/Vyvanse/Dexedrine for ADHD/fatigue; pain management with LDN, duloxetine, etc).
• 5. I need to do more research to support enough to present this, but we already recommend red light/infrared therapy for pain/inflammation,  and are looking into the application of HBOT for dysautonomia/POTS.

Presenter: KOICHI TANJI, ND, LMHC, FMAPS

Title of Talk:The Impact of Internet and Video Game Addiction on Brain Structure and Social Functioning in Individuals with Autism.

Abstract:

Introduction:

• Addressing the Expanding Epidemic: The Escalating Challenge of Screen Addiction Across All Age Groups
• Revealing the Pandemic Paradox: How Increased Screen Time Amplified Mental Health Struggles During Lockdowns
• Gaming's Neurochemical Nexus: Unveiling the Surprising Parallels Between Dopamine Release in Gamers and Drug Users
• Rewiring the Brain: Insights from Functional MRI Studies on Screen Addiction and its Resemblance to Substance Abuse
• Recognizing the Overlap: The Intersection of Screen Addiction and Autism Spectrum Disorder

Treatment and Transformation:

• Healing through Detox: How Treating Screen Addiction Can Positively Impact ASD Symptoms
• The Power of Technology: Leveraging Screen-Based Communication Tools for ASD Individuals
• Balancing Act: Navigating the Fine Line Between Screen Use as a Helpful Tool and Potential Dependency
• A Path to Recovery: Transformative Stories of ASD Improvement through Gaming Addiction Treatment

Conclusion:

• Unveiling the New Reality: The Significance of Screen Addiction in the Modern Age
• Empowering MAPS Doctors and Members: Equipping Them to Support Families Dealing with Screen Addiction Challenges

Presenter: TOM MOORCROFT, DO

Title of Talk: OPTIMIZING ENERGY, FOCUS & AUTOPHAGY NATURALLY

Abstract:

There are common ways of thinking about energy and supporting mitochondria. Most include taking the nutritional co-factors required to make energy as part of the electron transport chain and avoidance of environmental toxins.

While these are important pieces of the energy and healing puzzle, small doses and duration of stress exposure, hormesis, is actually a more effective and less expensive strategy. In this presentation, I will provide an overview of some of the ways to activate autophagy (Intracellular clean up) and mitogenesis (the creation of new mitochondria, the body’s energy factories) that are easily accessible to everyone - practitioners and their patients. Many of these are things kids actually love and can be easily applied despite sounding difficult at a surface level.

One strategy often overlooked is the use of intermittent hypoxia to drive the two key aspects of healing. I’ll review how this works and several different options for introducing intermittent hypoxic training (IHT) into one’s personal and professional practice. I will discuss several studies specific done with children and how to apply IHT in a realistic and effective way in children, both in your practice and as a parent. This is also an amazing tool for parents and practitioners to de-stress and revitalize for the incredibly important work they do o a daily basis.

By the end of the presentation, attendees will have a new/better understanding of the physiologic drivers of intracellular waste removal and natural energy creation and simple, effective tools to implement in their practices and in their lives. Optimize detoxification and energy production, naturally, for optimal health and healing.

Presenter: KURT WOELLER, DO

Title of Talk: TROUBLESHOOTING NEGATIVE BEHAVIORS, COMMON PROBLEMS, AND VARIOUS CLINICAL ISSUES IN ASD

Abstract:

Behavioral problems in autism are common. The same or similar behavioral problems can also occur in other special needs children. A list of these problems can be extensive, but primarily includes aggression, anxiety, compulsivity, hyperactivity, hyperexcitability, heightened fear response, impulsivity, obsessions, and self-injury. There are many common physiological issues such as digestive disorders, sleeping issues, sensory seeking behavior, etc., that may be linked to these common behavioral issues. Multiple factors may prompt a healthcare provider to begin laboratory evaluation along with a deep dive into the clinical history to discover some of the reasons for behavioral problems. It is important for everyone involved to be able to distinguish between behavioral issues that may be linked to underlying health issues and behavioral problems that are simply behavioral in nature. Not all behavioral issues are linked to an underlying biomedical condition.

This lecture by Kurt N. Woeller, DO details in open lecture format and case study scenarios, various negative behaviors, common problems, and clinical issues seen within his clinical practice for over 25 years. For example, is a child's rocking behavior on the edge of furniture just a common self-stimulatory behavior or could it be clue to an underlying condition? Is a child's aggression caused only by his constipation or could circumstances at home allow him to abuse certain family members? These are just a few examples of different clinical scenarios to be explored in this informative lecture.

The goal of this lecture is to help the practitioner distinguish between various possibilities for certain behavioral problems and strategies to consider before moving forward with care. Each practitioner will learn:

• Troubleshooting common problems such as negative behaviors seen with individuals on the autism-spectrum.
• Certain treatment intervention to consider based on the behavioral problem.
• Understand that not every problem in autism is related to a biomedical issue.

Presenter: KURT WOELLER, DO

Title of Talk: TROUBLESHOOTING NEGATIVE BEHAVIORS, COMMON PROBLEMS, AND VARIOUS CLINICAL ISSUES IN ASD

Abstract:

Behavioral problems in autism are common. The same or similar behavioral problems can also occur in other special needs children. A list of these problems can be extensive, but primarily includes aggression, anxiety, compulsivity, hyperactivity, hyperexcitability, heightened fear response, impulsivity, obsessions, and self-injury. There are many common physiological issues such as digestive disorders, sleeping issues, sensory seeking behavior, etc., that may be linked to these common behavioral issues. Multiple factors may prompt a healthcare provider to begin laboratory evaluation along with a deep dive into the clinical history to discover some of the reasons for behavioral problems. It is important for everyone involved to be able to distinguish between behavioral issues that may be linked to underlying health issues and behavioral problems that are simply behavioral in nature. Not all behavioral issues are linked to an underlying biomedical condition.

This lecture by Kurt N. Woeller, DO details in open lecture format and case study scenarios, various negative behaviors, common problems, and clinical issues seen within his clinical practice for over 25 years. For example, is a child's rocking behavior on the edge of furniture just a common self-stimulatory behavior or could it be clue to an underlying condition? Is a child's aggression caused only by his constipation or could circumstances at home allow him to abuse certain family members? These are just a few examples of different clinical scenarios to be explored in this informative lecture.

The goal of this lecture is to help the practitioner distinguish between various possibilities for certain behavioral problems and strategies to consider before moving forward with care. Each practitioner will learn:

• Troubleshooting common problems such as negative behaviors seen with individuals on the autism-spectrum.
• Certain treatment intervention to consider based on the behavioral problem.
• Understand that not every problem in autism is related to a biomedical issue.

Presenter: ANJU USMAN SINGH, MD, FMAPS

Title of Talk: MANAGING THE GUT MICROBIOME

Abstract:

The gut is the second brain. Improving gut health is becoming the cornerstone of improving brain health. The importance of absorption, digestion, the gut microbiome, vagus nerve function, SIBO/SIFO, and motility seems to play a huge role in neurological health. In my experience, supporting the gut through diets, exercise, nutrients, and clean-up protocols, such as biofilm protocols, motility-enhancing agents and binders can help support improved gut-brain stability.

Presenter: NANCY O'HARA, MD, MPH, FAAP, FMAPS & MYRIAH HINCHEY, ND, FMAPS, MARY SAINTONGE, M.ED

Title of Talk:
Medically & Aesthetically:
Building or Enhancing Your Functional Medicine Practice

Abstract:

Join Nancy H. O’Hara, MD, MPH, Myriah Hinchey, ND, and Mary T. Saintonge, M.Ed, CAGS in discussing all of the aspects of setting up a successful functional medicine practice.

At many of these functional medicine conferences we discuss how to get to the root causes of illness, but we do not often discuss the HOW TO of setting up that practice in an integrative and functional way.

Nancy O’Hara, MD, MPH, FAAP, FMAPS will discuss the medical, legal, practical, and functional issues in setting up a practice, all from an allopathic perspective. Who do I consider adding to my practice? What are the legal recommendations? What are the practical ways to do this?

Dr. Hinchey, ND will discuss the practical and functional issues of setting up a practice, selling supplements, and setting up other companies from a naturopathic perspective. How do I integrate with my community? How do I sell supplements?

Mary Saintonge, M.Ed., CAGS will discuss the Feng Sui of setting up a practice. First impressions are formed in the first three seconds when walking into a new environment. The senses of sight, smell, sound, and touch are on alert and an individual is able to make a judgment based upon that initial view. When you have worked in an office for a while, you become desensitized to all the different elements that belong in the space and forget to take a fresh look at what has been accumulated and arranged in the work environment.

There are 5 simple steps to creating a more safe, serene, and inviting work environment. Detoxing your space can provide benefits for you as well as your patients. Just be open to change, keep a flexible mind, and be ready to learn how to remake your space, your practice, and the lives of you and your patients.

Presenter: KAREN VON MERVELDT-GUEVARA, MD

Title of Talk:The crucial role of Thiamine (B1) in speech development, maternal risk factors and genetic implications - Prevention and Therapy

Abstract:

The contribution of B1 deficiency as a stand alone factor and the subsequent drain on Biotin as a compounding factor to impaired speech development

Few publications have as clearly demonstrated the impact of B1 (Thiamine) deficiency on speech development, syntax and lexical retrieval, as the article "Delayed language development due to infantile thiamine deficiency" by Aviva Fattal-Valevski et al. (2009) based on the longitudinal study of 20 children in Israel who had been exposed to a thiamine deficient soybased formula in infancy.

Thiamine deficiency is largely seen as a problem existing in underdeveloped countries, especially in the Asian hemisphere known for B1-deficiency caused by consumption of processed, B1-devoid white rice.

Little are we aware of the consequences of high caloric malnutrition and subsequent widespread B1-deficiency in the general population in our industrialized nations, though the increasing case load of non-alcoholic fatty liver disease as a result of these life style changes in an ever younger patient population is noted.

B1-deficiency and non-alcoholic fatty liver disease often tied in with latent or overt T2D and/or gestational diabetes are not only maternal risk factors for pre-eclampsia and eclampsia, yet are risk factors for the offspring to develop autism spectrum disorders and to suffer in particular from delayed speech development affecting higher cognitive functions as well as sensorineural disorders affecting swallowing, tongue movement and the motoric aspects of speech development.

Lastly, let us take a look together at genetic challenges in B1 processing and B1-dependent enzymes that compound the problem of B1-insufficiency and contribute to problems with speech development in our pediatric patients.

Presenter: BRUCE PATTERSON, MD

Title of Talk:LONG COVID DIAGNOSIS AND DIFFERENTIATION USING MACHINE LEARNING AND CYTOKINE HUBS

Abstract:

Background: Long COVID or Post-acute sequelae of COVID-19 (PASC) is a growing healthcare and economic concern affecting as many as 10%-30% of those infected with COVID-19. Although the symptoms have been well-documented, they significantly overlap with other common chronic inflammatory conditions that could confound treatment and therapeutic trials.

Objectives:

Methods: A total of 236 patients including 64 with long COVID/post-acute sequelae of COVID-19 (PASC), 50 with myalgic encephalomyelitis-chronic fatigue syndrome (ME-CFS), 29 with chronic Lyme disease, and 42 post-vaccine individuals with PASC-like symptoms (Long Vax)) were enrolled in the study. We performed a 14-plex cytokine/chemokine panel previously described to generate raw data that were normalized and run in a decision tree model using three different machine learning algorithms. This training set was then used to blindly characterize 157 patients who presented with fatigue, brain fog, and post-exertional malaise. The algorithm was used to classify these conditions in distinct groups despite their similar symptoms

Results: PASC, chronic lyme, ME-CSF, long Vax and acute COVID-19 disease categories were classified by our machine learning/cytokine hub based CART algorithm with an average sensitivity (94%) and specificity (98%) amongst the categories. Interestingly, six different immunotypic subgroups of ME-CFS were identified.

Conclusions: Proper classification of these inflammatory conditions with very similar symptoms is critical for proper diagnosis and treatment. In the ME-CFS group, six different subgroups were identified which fits with the heterogeneous etiologies of this condition.

Presenter: LARRY PALEVSKY, MD

Title of Talk:RESTORATION OF PARASYMPATHETIC FUNCTION TO MAXIMIZE HEALING & RECOVER BRAIN DEVELOPMENT FOR SPECIAL NEEDS CHILDREN

Abstract:

Children with chronic health conditions, especially those with neurodevelopmental disabilities, walk around in a perpetual state of inflammation. As a result, their bodies are often in states of elevated adrenaline levels characterized by dilated pupils, inability to sit still, poor sleep, constipation, frequent verbal and physical stims, poor eye contact, trouble self-regulating, aimless and purposeless involuntary movements, aggressive and impulsive behaviors, increased tantrums, gross and fine motor delays, and speech delays. Inflammation is perpetually circulating in their bodies, and; inflammation keeps entering their bodies on a regular basis from their environmental expsoures, and; the efficiency with which their bodies are able to excrete and eliminate the inflammation is often compromised. This scenario leaves these children in a perpetual state of autonomic dysregulation.

Parents and practitioners alike are anxious to detoxify these children as soon as possible. Nonetheless, detoxification is ill-advised when children are in such high adrenaline states. Care must be taken to work towards autonomic regulation, first, before any intense detoxification can be tolerated. In this presentation, I will review the following functions of the body (exhalation-lungs; urination-kidneys; stooling-intestines; sweating and smelling-skin; sleeping and resting-nervous system, and; mucous production-the immune system) and demonstrate how each and every one of these systems is regulated by parasympathetic function to help restore autonomic regulation. In fact, these systems represent THE anti-inflammatory processes in the body, whereby inflammation is effectively removed from the body, to ensure lower levels of inflammation and adrenaline.

In high adrenaline states, these anti-inflammatory/parasympathetically driven body functions are compromised. As such, detoxification, and the removal of inflammatory material in these children, is compromised. I will demonstrate how parents and practitioners could best assist the progress of their childrens’ recovery by first working to remove and reduce the inflammatory material coming into their bodies on a regular basis from their environmental exposures. In so doing, improvements in exhalation, urination, stooling, sweating and smelling, sleeping and decreased mucous production, can all make way for the real work of getting to the materials in their bodies that are most contributing to the ongoing inflammation in these children. In addition, as inflammatory material entering their bodies are removed/ reduced, adrenaline levels decrease and the children begin to slow down, sleep better, stool better, regulate better, behave better, and be in a more autonomically regulated chemistry to tolerate detoxification.

Lastly, I will review brain development in children. I will show the attendees how routine brain development starting at birth proceeds from the hindbrain to the forebrain. The hindbrain, which includes the medulla, cerebellum and pons, is the most dominant, and most rapidly developing part of the infant and early-childhood brain. Newborns are born in very high states of adrenaline and, as the adrenaline wanes in infancy and through toddlerhood, and cerebellar-based involuntary movements become voluntary, hindbrain dominance also wanes, allowing brain development to proceed forward. This process begins midbrain development where physical, emotional and sensory experiences begin to take hold.

Inflammation and toxicity exposure in utero and in early infancy and toddlerhood, however, adversely affect the most vulnerable, and most rapidly developing part of the infant brain, the hindbrain. Increased inflammation and elevated adrenaline levels allow for persistent hindbrain dominant adrenalized fight or flight chemistry, making it near impossible for brain development

Presenter: BOB MILLER, BCTN

Title of Talk: FERROPTOSIS, AND HIGH INTRACELLULAR CALCIUM IN AUTISM SPECTRUM DISORDER

Abstract:

Two new pathways are emerging as a potential cause of the neuroinflammation in autism resulting from environmental factors that are relatively new from a historical perspective and amplified in those with a genetic predisposition for increased sensitivity.

Ferroptosis Iron dependent Ferroptosis was first proposed in 2012 by Scott Dixon as a non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species. Recent research has systematically elucidated the intricate correlation between Ferroptosis and ASD, and has provided a promising Ferroptosis score model to predict the molecular clusters and immune infiltration cell profiles of children with ASD.

Genetic SNPs in HFE, SLC40A1, GPX4, XcT, GSR, GSS, NRF2 and KEAP1 creates more susceptibility to Ferroptosis.

High Intracellular Calcium from the Aryl Hydrocarbon Receptor

Although critical for bone and teeth health, and multiple other factors, high levels of intracellular calcium have been associated with autism. The role of calcium signaling dysregulation in monogenic and polygenic neuropsychiatric disorders has been well established. The genomics of autism spectrum disorder points to a “hub” role for calcium signaling where diverse genetic and environmental risks converge. Excess calcium leads to endoplasmic reticulum stress causing calcium to spill over into the mitochondria resulting in mitochondrial dysregulation, which is a hallmark of not only neurodegenerative diseases, but autism as well.

Genetic weakness in kynurenine pathway and multiple environmental factors such as mold, high iron, arachidonic acid, aromatic hydrocarbons, lead and mercury are causing the aryl hydrocarbon receptor (AHR) to stimulate increased oxidative stress, mast cell activation and excess intracellular calcium.

Genetic SNPs in AHR, AHRR, ARNT, TCN1, TCN2, SLC19A1 and MTHFR C677T may make an individual more susceptible to inflammation from the aryl hydrocarbon receptor.

High Intracellular Calcium from the NMDA Receptor

Environmental factors such as Phthalates, EMF, Glyphosate, and HFCS are stimulating the NMDA receptor to bring excess intracellular calcium into the cells which then triggers mast cells.

Genetic weakness in ACMSD, PON1, CACNA1C, SLC30A8, GRIN1, GRIN2A, GRIN2B, may make an individual more susceptible to inflammation from excess intracellular calcium from the NMDA receptor.

Compensating for the genetic weakness, as well as reducing or eliminating the environmental triggers may be helpful in reducing the severity of neuroinflammation.

Presenter: DAWNMARIE GAIVIN, RN, BSN, AT-ACP

Title of Talk: EFFICACY OF SPELLERS METHOD FOR PATIENTS DIAGNOSED WITH INTELLECTUAL DISABILITY, DOWN SYNDROME, AND AUTISM

Abstract:

Since the 2023 release of the documentary SPELLERS, word has reached thousands of new families about the hope of using letterboards as an effective way to achieve robust communication with nonspeakers. But who exactly is defined as a nonspeakers and how does Spellers Method work when other forms of AAC (augmentative & alternative communication) might have been deemed ineffective prior? In this presentation you will learn for whom, how, and why Spellers Method is achieving results.  Through various case studies you will also witness firsthand how communication progress is achieved through consistent motor practice and proper coaching strategies.

By the end of this presentation, the participant will be able to explain the difference between speech & language, the four types of motor movements, and how motor planning difficulties such as apraxia/dyspraxia can impair a child’s ability to "show what they know."

The participant will be able to identify which patients Spellers Method (or spelled communication) is an appropriate form of augmentative & alternative communication for.

The participant will understand the concept of motor coaching and be able to use this strategy when working with a nonspeakers in their clinical practice

Presenter: DANA JOHNSON, PHD, MS

Title of Talk: BLENDING MOTOR PLANNING AND NEURODEVELOPMENTAL OPTOMERTY TO ACCESS COMMUNICATION

Abstract:

Our movements rely heavily on our vision and ocular motor control, yet vision is often overlooked as an integral part of successful motor function. Vision gives information about our body position in space and feedback to refine movement accuracy. It enables us to react to changing environments and adapt on the fly. Several studies have outlined the ocular motor and vision differences among the autistic population (Caldani, et al., 2019, Schmitt et al., 2014), however, interventions targeting both vision and motor planning to support volitional movement and communication are limited. This presentation will follow a case study of one nonspeaking patient who was assessed by neurodevelopmental optometry and participated in both a vision therapy protocol and a functional movement-based program to support communication using the Spellers Method. The discussion will highlight the individual differences seen in autistic patients to warrant a functional-based movement and neurodevelopmental vision program.

Presenter: SVETLANA MASGUTOVA, PhD, Creator of the MNRI® / Masgutova Method® Leah Light, Au.D., Founder of the Brainchild Institute and MNRI® Core Specialist and Instructor

Title of Talk: Effects of auditory reflex maturation on the non-classic neuropathways for speech-language development and communication

Abstract:

This presentation explores how the maturation and integration of primary auditory reflexes are foundational for facilitating speech-language development and communication in infants and children, individuals with speech development delays and deficits, and nonspeakers.

The brain develops in a bottom-up manner. Following the proper chronology of an infant’s / child’s speech and language milestones is essential. Therefore, it is crucial to engage effective language, speech and communication interventions that support the natural course of development. Specific MNRI® oral-facial-motor and visual-auditory neuromodulation techniques target specific non-classic neuropathways and subcortical structures of the brain to support the neurophysiological mechanisms of language and speech development.
MNRI® reflex integration techniques complement communication- and language-focused cortical-driven interventions, thereby aiding developmental professionals and parents in helping a child achieve more efficient speech and language (Wernicke’s auditory center and Brocka’s speech center) development progression.

Presenter: NICOLA ANTONUCCI, MD

Title of Talk: Innovative approaches and therapies to develop language in Autism Spectrum Disorders: the complessity of a strategy.

Abstract:

Language and speech issues are key components of ASD symptoms and current therapies find difficult to face. The speaker will describe a complex strategy of combining interventions aimed at, on the one hand, reducing neuroinflammation by using substances such as ultramicronized PEA, reducing oxidative stress by using supplements such as sulforaphane, supporting methylation pathway by using methylcobalamin, methyfolate, and betaine, and, on the other hand, increasing brain plasticity and improving overall brain development by using drugs such as memantina, citicoline and donepezil. The combination of these interventions shows significant improvements in children with ASD to promote expressive language and verbal communication.

Presenter: ARMEN NIKOGOSIAN, MD, FMAPS

Title of Talk:THE GAP BETWEEN INTENTION AND ACTION: ALTERED CONNECTIVITY AND GABA/GLUTAMATE MEDIATED SYNCHRONY

Abstract:

In this lecture we will be discussing GABA and it’s role in motor planning and speech in ASD.

The imbalance of glutamic acid and GABA in autistic individuals directly impacts many different areas of the brain, affecting motor planning, initiation, speech and apraxia overall.

Presenter: LIZ MUMPER, MD, FAAP, FMAPS

Title of Talk:FOUNDATIONS OF BIOMEDICAL THINKING

Abstract:

Frequently, we are not aware of our thought process; and this can get in the way of appropriately managing our patients. In this presentation, we will identify the key differences in the thought process behind the biomedical approach versus our standard medical model. Understanding the interconnectedness of our systems and how manipulating one thing in one system can impact the entire body. We will investigate how to change the thought process when we approach our patients. As Dr. Sid Baker once said, "If you are having problems answering a question about how to treat a patient, maybe you are asking the wrong question."

Presenter: CADE LARSON, ELIZABETH BONKER & VINCE RINICELLA

Title of Talk:BIOMEDICAL INTERVENTIONS AND COMMUNICATION- THE KEY TO SUCCESS, STRAIGHT FROM THE VOICE OF SPELLERS

Abstract:

Biomedical Interventions and Communication, the keys to success - rom the voice of three non-speakers

Elizabeth Bonker was the first non speaking valedictorian in the United States; Cade Larson drove his own care to recover from Cancer; Vincent Rinicella’s story was responsible for a book that became a movie and saved hundreds of thousands; yet none of this would have occurred if they had not gone through years of dedicated biomedical treatments.

Elizabeth, Cade and Vince are changing the world with their advocacy. In this lecture, you will hear them describe in their own words, how critically important biomedical interventions were in breaking out of their silence to achieve their dreams. This lecture is not to be missed!

*All questions will be answered live.

Presenter: CHRISTOPHER W. SHADE, PHD

Title of Talk:CANNABINOIDS, BILE FLOW, AND BINDERS FOR SUCCESSFUL DETOXIFICATION IN AUTISM

Abstract:

Description:

Poor detoxification capabilities and chronic toxicity are fundamental aspects of autism spectrum disorders with detoxification protocols being imperative to successful outcomes. Improperly designed protocols can lead to unwanted symptoms that make these much-needed therapies difficult to continue.

Unfortunately, the core biochemical mechanisms governing the body’s detoxification system are poorly understood and most detoxification programs miss three critical aspects:

• Addressing and reducing system-wide inflammation to unlock detoxification pathways;
• Matching liver chemistry upregulation to bile flow;
• Using binding agents to catch toxins in the GI tract for excretion.

In this lecture, Dr. Shade will discuss the endocannabinoid system and the strategic use of CBD to address neuro and systemic inflammation to support detoxification. He’ll also explain the chemistry behind the three phases of detoxification – highlighting the importance and use of cholagogues to support bile and toxin movement, and the use of binding agents to support their safe and effective excretion.

Presenter: DEBBY HAMILTON, MD, MPH, IFMCP

Title of Talk:Identifying and Healing Mitochondrial Dysfunction in Children with Chronic Illness

Abstract:

Objectives:

• Learn the signs and symptoms associated with mitochondrial dysfunction in children.
• Learn ways to test for mitochondrial dysfunction in children.
• Understand the pathology associated with mitochondrial dysfunction including oxidative stress and inflammation and how this correlates with chronic disease.
• Discuss treatment options to support mitochondrial function and counteract oxidative stress in children with chronic disease.

Presentation Synopsis:

Children with autism spectrum disorders, ADHD, and autoimmune issues have similar underlying pathology of their chronic disease including mitochondrial dysfunction as in adult illness. Signs and symptoms of mitochondrial dysfunction can be different in children though. Diagnosis of mitochondrial dysfunction is important because there are multiple nutrients that can influence mitochondrial function and treatment needs to be targeted. Many factors contribute to the development of mitochondrial dysfunction including infections, toxins, and oxidative stress so identifying and treating those issues also is important. Identifying and healing mitochondrial dysfunction is a key component of ongoing treatment for our children with chronic illness.

Presenter: DAVID DORNFELD, DO, FMAPS

Abstract:

When challenged with trying your help a nonverbal Autistic child become more neurotypical, one needs to become a “detective” to find out the best combination of therapies that will be most efficacious. The cases I will present - share some of the multiple pathways which I utilize, in order to help reverse the negative traits of ASD and its complications. At the same time one needs to support the person’s health needs nutritionally, to become more neurotypical, have better bowel function, and improve his/her speech capabilities.

Presenter: MICHAEL ELICE, MD, FMAPS

Abstract:

When faced with a child who is called autistic but is also overweight, rashy, hyperactive, can't sleep, and has trouble passing stool, how should this child be properly evaluated? This case presentation will demonstrate the essentials of a complete history, physical exam, lab work, and environmental investigation in order to properly diagnose and treat the child. I will also demonstrate how the child can improve clinically based on an appropriate treatment plan

Presenter: ANJU USMAN SINGH, MD, FMAPS

Title of Talk:CASE PRESENTATIONS: Unveiling Success: A Comprehensive 3-Year Case Study of Biomedical Interventions in Child Health Recovery

Abstract:

Dr. Usman Singh will review a case of a child over the course of 3 years. She will discuss specific biomedical interventions that were successful in recovering his health. She will review key points in the history as well as laboratory findings that helped in guiding the decision-making process. This case will highlight genomics, microbiome balancing, and detoxification strategies.

Presenter: JAMES NEUENSCHWANDER, MD, ABIM/AAPS, ABIHM, BCEM/AAPS, FMAPS

Title of Talk:CASE PRESENTATIONS: Exploring Diverse Presentations and Applying MAPS Principles for Successful Outcomes

Abstract:

In this 60-minute presentation, Dr. Neu will review three cases: one of a loss of language in a non-autistic child, one of a child with growth delay, and the final case of a toddler actively undergoing a regression. He will interactively present these cases to allow participants to comment on the case and make their own suggestions about cause and treatment. He will then review his approach and how he applied MAPS principles to each of these cases for a successful outcome.

Presenter: MARIA GAHRY, DNP, RN, FNP, FMAPS

Title of Talk:CASE PRESENTATIONS: How to Improve Behavior and Increase Speech with an Integrative and Individualized Approach

Abstract:

Case presentation of a boy with a speech delay who made great speech gains and behavioral improvement with easy-to-implement autism-specific multivitamins and focused gut interventions. The case will include history, excerpts from specialty labs, and 16sRNA stool tests. The case will cover approximately 1.5 years of follow-ups and interventions.

Presenter: NANCY OHARA, MD, FMAPS

Title of Talk:CASE PRESENTATIONS: Stuttering and Post-Acute InfectionSyndromes (PAIS): Why Did My Patient Suddenly StartStuttering and What Can I Do?

Abstract:

PAIS, PANS & PANDAS are complex autoimmune diseases that require a multi-system approach. Multiple studies demonstrate that speech disfluency (including tics, stuttering and baby talk) can be seen with Autoimmune or Basal Ganglia Encephalitis. Clinical experience and studies demonstrate a link between infections, including strep, viruses, mycoplasma, lyme and co-infections, and speech dysfluency. These changes in communication can be reversed with a functional medicine 3-pronged approach of immune modulation, appropriate antimicrobials and symptoms support. Dr. O’Hara will discuss a child with an abrupt onset of stuttering reversed with this 3-pronged approach.

The participant will be able to understand the assessment, diagnosis and treatment of speech regression and disfluency in PAIS and Basal Ganglia Encephalitis through case study presentation.

The participant will be able to differentiate causes and pathophysiology of speech regression in autoimmune encephalitis.

The participant will be able to define the treatments for such PAIS-induced regression in communication.

Presenter: RICHARD BOLES, MD

Title of Talk:Genetic Testing in Autism Results in a Precise Diagnosis and Individualized Treatment Options in Most Cases

Abstract:

OBJECTIVE: To determine the current sensitivity of trio whole genome sequencing (trio-WGS) in autism, as the last decade has seen dramatic improvements in the proportion of the genome clinically sequenced (e.g., < 1% to> 99%), accuracy, bioinformatic tools, and variant databases. Additionally, the current literature is almost entirely from academic research centers, with essentially no contribution from independent/private physician providers.

METHODS: NeurAbilities Healthcare® is an independent organization specializing in neurodevelopmental disorders. As part of our routine clinical practice, we analyzed the raw DNA sequencing files on the Variantyx® (Framingham, MA) bioinformatics platform for the last 50 autism patients with trio-WGS.

RESULTS: Primary Diagnostic Variants (PDVs; meaning one gene contributes the bulk of genetic causation) were provided in 34/50 (68%) of cases, including 25 (50%) heterozygous de novo, 3 X-linked, 4 autosomal recessive, 2 autosomal dominant (affected parent), and 1 heteroplasmic maternal (mtDNA, one also has a de novo). All variants considered for PDVs were “Qualified”, defined as coding (changing the amino acid code), very rare, and evolutionarily conserved; in addition to published data linking that gene to autism. De novo variants in genes associated with autism were far more likely to be Qualified than non-qualified (control group, P=0.002, validating that most Qualifying variants are indeed disease-causal). Only 14/34 (41%) of PDV cases had the variant listed on the laboratory report. The “missed” cases predominately included genes with zero (novel etiologies in 14 cases) to ≤5 prior reported case reports. Many cases both with and without a PDV had inherited Qualifying variants in known autism-associated genes, suggesting polygenic inheritance. Thirty-three participants (66%) had treatment recommendation(s) based on DNA analyses, with a substantial proportion demonstrating anecdotal clinical improvement on this treatment; data analysis is ongoing.

CONCLUSIONS: Our results demonstrate a high yield of trio-WGS for revealing molecular diagnoses in autism that is greatly enhanced by re-analyzing DNA sequencing files. Many are de novo and represent un/under-published conditions. The pathways represented by these genes contribute to understanding genetic vulnerability to develop autism.

FUNCTIONAL-MAPS IMPLICATIONS: Scientific advances and clinical observation strongly suggest that autism is the result of a complex interaction between genetic predisposition and environmental triggers. Therapy is best attempted following a robust, personalized work-up for both. Based on the functions of the genes involved, many of the pathways are treatable, including cation transport, redox state/energy metabolism, amino acids, and neurotransmission. Our data also has implications to the rising prevalence of autism.

Presenter: Theoharis C. Theoharides. MS, MPhil, PhD, MD, FAAAAI

Title of Talk:Metalloproteinase-9 (MMP-9) is Released in the Brain and Disrupts Neuronal Connectivity in Autism Spectrum Disorder (ASD)

Abstract:

Autism Spectrum Disorder (ASD) is a major health issue as it involves 1 in 36 children without distinct pathogenesis or effective treatment. There has been evidence of localized inflammation in the amygdala and hippocampus, areas involved in memory and behavior. Matrix metalloproteinase-9 (MMP-9) is an enzyme that destroys the brain matrix and can disrupt neuronal connectivity. We recently reported that MMP-9 was elevated in the brains of patients with ASD as compared to normotypic controls, and showed that both brain mast cells and the brain defenders microglia were positive for MMP-9. We further showed that MMP-9 can be released from cultured human microglia stimulated with the peptide neurotensin and the mycotoxin Ochratoxin A. Pretreatment of microglia with the natural flavonoid luteolin, previously reported to inhibit release of pro-inflammatory molecules from both mast cells and microglia, also inhibited release of MMP-9 from activated microglia. Preliminary results indicate that MMP-9 is significantly elevated in the serum of children with ASD as compared to healthy controls but was reduced after treatment with the luteolin-containing liposomal dietary supplement NeuroProtekR. In conclusion, MMP-9 may contribute to the development of ASD and could serve both as a prognostic biomarker and as target for treatment. www.drtheoharides.com

Objectives

• The tissue disrupting enzyme MMP-9 is increased in the brain and blood of patients with ASD.
• MMP-9 can be released from brain microglia stimulated by a a neuropeptide and a mycotoxin.
• The natural flavonoid luteolin can inhibit release of MMP-9.

Presenter: Taylor Bean, ND, FMAPS

Title of Talk:The Power of Vitamin A

Abstract:

One of the most underestimated yet powerful vitamins we have among us is vitamin A. This important vitamin was first discovered simultaneously in 1913 by two separate research pairs working at the University of Wisconsin and Yale University. Today, we have come to understand much more behind the power of Vitamin A – from epithelial tissue support, growth and bone development, night vision, immune function, warding off severe cases of measles to anti-cancer support.

Health agencies have become relucent to suggest vitamin A due to its potential toxicity; however, with understanding what toxicity levels are, we can prescribe this vitamin safely. We will discuss maintenance dosages for our pediatric population along how we can support them during or after infections. Where do we get vitamin A in our food? We will discuss both animal and plant sources and what the differences are.

Objectives

• How Vitamin A plays a critical role in immune function
• Dosing in pediatrics for both maintenance and treatment
• Toxicity

Presenter: Arthur Krigsman, MD

Title of Talk:Treatment of underlying inflammatory bowel disease in children with ASD significantly improves GI symptoms, cognition, and behavior

Abstract:

Gastrointestinal disease is one of the leading medical comorbidities in children with autism and is responsible for a great deal of physical suffering. This presentation describes our most recent study, funded by the Brain Foundations, in which we show that treatment of underlying inflammatory bowel disease treats not only the presenting GI symptoms, but also significantly improves cognition and behavior using standard, validated ASD metrics. This is exciting as it provides yet another intervention for ASD that will improve the lives of these children.

Presenter: Bri Kurcsak, MS, OTR/L

Title of Talk:Investigating the Gut-brain Connection: Exploring the intersection of Picky Eating, Constipation, Mouth Breathing, and Parasympathetic Nervous System Dysfunction

Abstract:

This presentation delves into the intricate relationship between picky eating behaviors, constipation, breathing challenges, and parasympathetic nervous system dysfunction, explaining their collective impact on gut health. The interplay of these factors contributes to gastrointestinal dysfunction, disrupting the delicate balance of the gut microbiome and impairing digestive processes. Through an integrative approach and in interdisciplinary lens, this lecture explores the underlying mechanisms linking these phenomena, highlighting the role of the parasympathetic nervous system in regulating gut function. Evidence-based strategies for addressing these interconnected issues will be discussed, to enhance understanding and inform holistic interventions aimed at optimizing gastrointestinal function and promoting improved health outcomes.

This lecture will be engaging and interactive, featuring real-life case studies to illustrate key concepts. Additionally, attendees will receive a screening tool and flow chart that healthcare providers can utilize to identify these challenges, along with actionable strategies for addressing them effectively.

Objectives

• Understand the complex interrelationship between picky eating behaviors, constipation, breathing challenges, and parasympathetic nervous system dysfunction.
• Explore the mechanisms through which these factors contribute to gut dysfunction and disrupt the gut-brain axis.
• Gain insights into the role of the parasympathetic nervous system in regulating gut function and its implications for therapeutic interventions.
• Identify evidence-based strategies and innovative therapeutic modalities for addressing picky eating, constipation, breathing challenges, and parasympathetic nervous system dysfunction to promote gut health.
• Discuss useful strategies for integrating dietary modifications, lifestyle interventions, and therapies to promote gut health and improve overall well-being in individuals affected by these interconnected issues.
• Leave with practical techniques that will aide your approach in restoring gut health and fostering overall well-being in individuals affected by these interconnected issues.

Presenter: Kathleen Johnson, ARNP, DNP, PMHNP-BC, FNP-BC, C-PMHS

Title of Talk:Autism, ADHD and EDS

Abstract:

Autism Spectrum Disorder (ASD) prevalence has increased to impact 1:36 people (2.78%) with high rates of co-occurring behavioral health challenges, such as attention deficit hyperactivity disorder (ADHD), anxiety, or depression (77.7%; 1, 2). Ehlers-Danlos Syndrome and Hypermobility Spectrum Disorders (EDS/HSD) are genetic disorders that affect connective tissue matrix proteins and often co-occur with ASD and ADHD (3). Connective tissue disorders affect collagen and elastin and contributes to many physical and behavioral health symptoms, such as anxiety, depression, gastrointestinal problems, sleep challenges, fatigue, vertigo, tinnitus, or pain (3). Understanding the overlapping symptoms of autism, ADHD, and co-occurring symptoms of EDS/HSD, how to evaluate, give conservative care, and utilize medications or supplements as appropriate may help increase the quality of life and achievement of life goals with pediatric patients and their families.

Objectives

• Participants will become aware of the current/growing prevalence and co-occurrence of autism, ADHD, and Ehlers-Danlos Syndrome/Hypermobility Spectrum Disorders (EDS/HSD), and the overlapping symptomology that impacts quality of life.
• Participants will gain tools for diagnostic evaluation of EDS/HSD in the neurodiverse population.
• Participants will gain treatment options to apply in clinical practice, including appropriate referral options, conservative therapies, supplement and pharmacologic treatment of symptoms, and integrative medicine applications to consider.

Presenter: Gretchen Perry-Emery, APRN, FNP-BC, NP-C, FMAPS

Title of Talk:Case Presentations - The Therapeutic Role of Donkey Milk in Immune and Microbiome Regulation.

Abstract:

For years providers have sought the use of Camel Milk as an adjunct therapy to recover microbiome health in children on the Autism Spectrum. The use is controversial due to the potential for folate antibody induction. Concerns have also been voiced about the source and controlling for potentially pathogenic bacteria in raw milk that could lead to more microbiome dysregulation in gastrointestinal tracts that are already weak in defending and controlling for unwanted organisms.

More recently Donkey Milk has been of interest. Donkey milk remains controversial due to the concerns about folate receptor antibody induction in the autism community. However, it is studied and known to be the closest thing to breast milk of any species to date. The sourcing of Donkey Milk from Portugal, and the techniques used to preserve nutritional value, immunoglobulin properties, and beneficial bacteria are unique and have allowed for FDA approval.

In this presentation, I will review the unique properties of Donkey Milk as a therapeutic option for immune and microbiome support and discuss the research/evidence behind those benefits. I will also review the process used to preserve these beneficial properties and address the concerns about folate receptor antibodies with the research available to date. Last, case presentations where it has clearly been a game changer in patients with multiple allergies/food sensitivities and neuro-immune symptoms.

Objectives

• Review the protein and immunologic differences between cow, donkey, human and breast milk
• Discuss the mechanism behind preserving the milk to maintain beneficial properties, as well as sourcing, availability, and affordability.
• Case study reviewing the use in one to two patients where it has been a game changer in QOL and overall microbiome/immune health.

Presenter: Richard Frye, MD, PhD, FMAPS

Title of Talk:The influence of Microbiome Metabolites on Mitochondrial Function in children with Autism Spectrum Disorder

Abstract:

Autism spectrum disorder (ASD) has been associated with mitochondrial disease and dysfunction. However the etiology of abnormalities in mitochondrial function is unknown as the majority of the cases of mitochondrial disease in children with ASD do not have any obvious link to genetic defects. Recent studies have linked changes in the microbiome to ASD. Enteric bacterial fermentation product such as propionic acid can be produced by gut bacteria that have been associated with ASD such as Clostridia. In addition, bacteria important for the production of butyrate tend to be underrepresented in the microbiome of children with ASD. Short-chain fatty acids, such as propionic acid and butyrate, can alter mitochondrial function, leading to altered bioenergetics. We have recent demonstrated that some children with ASD and mitochondrial disease have biomarkers of abnormal mitochondrial metabolism that parallel biomarkers previously identified in the propionic acid rodent model of ASD, suggesting that these children may have acquired their mitochondrial disease from changes in gut microbiome. In addition, in in vitro models we have demonstrated that both propionic acid and butyrate alter bioenergetics, stress response and immune pathways. This talk will review some of the links between microbiome metabolites and mitochondrial dysfunction as well as demonstrate the empirical evidence for such metabolites causing mitochondrial dysfunction in children with ASD.

Objectives

• Understand the association between autism spectrum disorder (ASD) and microbiome short chain fatty acids.
• Explore recent research findings linking changes in the gut microbiome to ASD.
• Evaluate empirical evidence demonstrating the impact of microbiome metabolites on mitochondrial bioenergetics.

Presenter: Kurt Woeller, DO, FMAPS

Title of Talk:Autism and Toxic Microbial Organic Acids – The Compounds Every Practitioner Should Know About and Why

Abstract:

The microbiome harbors trillions of micro-organisms, including various bacterial and fungal organisms. Certain bacteria and fungus produce organic acid compounds which can negatively affect an individual with an autism-spectrum disorder (ASD) in unique ways with regards to their cognitive function, behavior, and overall neurodevelopment. The influence of these compounds reaches beyond the digestive system and involves the brain and nervous system, as well as cellular and mitochondrial function. Testing for these compounds is available, but understanding what they do biochemically is key to clinical correlation and proper treatment.

This lecture by Kurt N. Woeller, DO, is based on his 25+ years in clinical practice using urinary organic acids testing for the accurate assessment of specific microbial compounds which have high clinical relevance for anyone on the autism-spectrum. Many behaviors such as impulsivity, hyperexcitability, and self-stimulation can occur from certain yeast and fungal toxins, whereas aggression, moodiness, and self-injury can manifest in the presence of specific bacterial toxins. The symptom picture can be more confusing when various bacterial and fungal toxins are present. Overlooking the existence of specific microbial compounds or not understanding their biochemical effects will often interfere with other biomedical interventions and slow progress for healing and clinical improvement.

The goal of this lecture is to help the new and established practitioners better understand the negative impact of certain microbial organic acid compounds on the autism-spectrum individual.

Objectives

• The main fungal compounds often seen in ASD, including those linked to mold exposure.
• The most common bacterial organic acid compounds and what their clinical significance indicates. This lecture will be a crash course in organic acids testing with a primary focus on the key microbial compounds necessary to understand when working with the ASD population.
• Examples of biochemical disruption that can occur from the presence of these compounds and what that means for the autistic individual.

Presenter: Erica Peirson, ND

Title of Talk:Immunometabolism, the importance of Metabolic rate in Neuropsychiatric and Neuroinflammatory conditions (or influence of Gut motility on Microbiome)

Abstract:

Given the role that infections play in the development of neuropsychiatric and neuroinflammatory conditions in children, the metabolic state of the child must be considered. The immune system is highly metabolic, depending on optimal lipid and glucose metabolism to function properly. The immune system abnormalities reported in children with autism and other neurodevelopmental conditions are characterized by a decreased number of lymphocytes and their reduced response to stimulation. Lymphocytes require optimal glucose uptake and metabolism for normal survival and function. In addition, a low metabolic rate contributing to poor immune system function can lead to loss of immunological self-tolerance. The role autoimmunity plays in autism is widely recognized yet the role that the metabolic state plays in the development of autoimmunity and overall immune system function deserves more attention. This lecture will review:

Objectives

• Role of metabolism in immune system function and links to autoimmunity
• Signs, symptoms and labs to detect low metabolic rate in children
• How to optimize metabolic rate to support the immune system

Presenter: Lindsey Wells, ND, FMAPS

Title of Talk:Role of Folate and Cerebral Folate Deficiency in Pediatrics

Abstract:

Cerebral folate deficiency has garnered significant attention for its involvement in Autism Spectrum Disorders (ASD), particularly in the context of speech and communication challenges. Beyond ASD, folate's influence extends to mental health, encompassing conditions such as treatment-resistant depression, anxiety, and various mood disorders. In this comprehensive lecture, we delve into the multifaceted role of folate and cerebral folate deficiency, exploring their impact not only on ASD but also on mood disorders and the intriguing connection to PANS/PANDAS.

Objectives

• Identify and describe the physiology of cerebral folate deficiency
• Appraise the scientific evidence of cerebral folate deficiency in pediatric population
• Treatment for cerebral folate deficiency

Presenter: Ari Calhoun, ND

Title of Talk:The First 1000 Days: Impact on Gut Health and Chronic Illness

Abstract:

The first thousand days of life, from conception to a child's second birthday, are critical for the establishment of gut health, and have significant implications for the risk of pediatric chronic diseases. A healthy gut is impacted by, and in turn impacts a variety of physiologic pathways that are correlated with chronic disease. Thus, the first thousand days of life represent a critical window of opportunity for promoting gut health and reducing the risk of pediatric chronic diseases. Optimizing maternal and infant nutrition, promoting breastfeeding, minimizing exposure to antibiotics and environmental toxins, and supporting a healthy gut microbiota during this period are essential strategies for promoting lifelong health and well-being. Early interventions aimed at preserving gut health and immune system function may have far-reaching implications for reducing the burden of chronic diseases in childhood and adulthood.

Objectives

• Name 3 factors that can disrupt the infant Microbiome
• Understand how breastfeeding modulates the developing microbiome
• Identify environmental insults to the fetal and infant gut.

Presenter: Kimberley Sukhum, PhD Researcher

Title of Talk:Building Microbiome Biomarkers to Understand and Optimize the Gut-Immune System Connection

Abstract:

The gut microbiome is integral to a child’s immune system development and is linked to various immune-related disorders. Research has linked gut microbiome imbalances and several health issues, including allergic disorders like asthma and eczema, autoimmune diseases such as Inflammatory Bowel Disease (IDB) and behavioral conditions like ADHD.

Shotgun metagenomics paired with AI technology stands out as an innovative tool in this field. Shotgun metagenomics allows for a detailed characterization, functional profiling, and probiotic/pathogenic strain tracking of the microbiome in children's guts. Then AI technology allows us to create microbiome evaluations and predictive biomarkers tailored for the pediatric population, opening the door for actionable insights.

This presentation will explore why using shotgun sequencing and AI technology is so transformative in children's healthcare. It will showcase how we can leverage AI to lead biomarker discovery, not only to enhance our understanding of pediatric conditions but also supports the advancement of targeted treatments and preventive strategies for children’ health with focus on allergic diseases initially, with future insights into behavioral, autoimmune, and metabolic health related conditions.

Objectives

• Atopic March and the role of the developing gut microbiome
• Review key microbes and their role in immune development
• Creating biomarkers and microbiome signatures using AI technology

Presenter: Krystle Dean Duru, DDS, Lynda Dean Duru, DDS

Title of Talk:Breathing, Feeding, and Growth: An Integrative Approach to Pediatric Dental Health

Abstract:

In the multifaceted realm of pediatric healthcare, the interplay between dentistry and overall health is increasingly recognized as a cornerstone of early childhood development. As board-certified pediatric dentists with a profound commitment to integrative approaches, our presentation aims to bridge the gap between traditional dental practices and holistic pediatric care. Our expertise spans across crucial areas such as tongue-tie management, sleep and airway assessment, neuromyofunction, and the overarching principles of integrative functional dentistry. Our goal is to equip functional and holistic providers with the knowledge and tools necessary to identify and address complex dental and facial growth issues from infancy through young adulthood, ensuring optimal health outcomes.

Our presentation will delve into the foundational aspects of pediatric dental health, beginning with the critical examination of a child's orofacial development. We will explore how subtle signs evident in facial structure and behavior can indicate underlying airway and breathing disorders. The discussion will extend to the growth of the face, emphasizing the vital roles of structure, function, and behavior in development. Highlighting the importance of breastfeeding not merely for nutrition but for facial and airway development, we will also tackle the critical roles of chewing and the preference for nasal over mouth breathing.

Sleep-disordered breathing will be a focal point, unraveling the pathophysiology behind this common yet often overlooked condition. Through our integrative lens, we will navigate the identification of dysfunction across various developmental stages, from infancy to adolescence, and outline targeted treatment strategies. Our approach emphasizes the necessity of a multidisciplinary team in managing these complex cases, underscoring the importance of thorough evaluation and follow-up post-tongue-tie release and continued growth guidance.

Moreover, we will address the crucial aspect of early interventions, shaped by environmental factors including maternal health and prenatal influences. By examining case studies and testimonials, we aim to provide a comprehensive understanding of the impact of early life interventions on long-term health and development.

The human skull and face, consisting of 22 bones intricately connected by sutures, form the cradle of our presentation. We will explore the significance of these structures, the developmental importance of the occiput, and the role of cranial nerves in maintaining the functionality of the head, face, and mouth. The birth story of a baby, encompassing various factors from delivery methods to early interventions, play a pivotal role in the optimal functioning of the newborn, affecting everything from tongue function and breastfeeding to digestion and sleep..

Our presentation is designed not just to inform but to empower pediatricians and healthcare providers with practical insights for Monday morning. By illustrating what to look for as warning signs of dental and facial developmental issues, we aim to foster a collaborative approach to early detection and intervention. Join us in exploring how an integrative approach to pediatric dental health can unlock the door to improved long-term outcomes for our youngest patients, setting the foundations for a healthier future.

Objectives

• Understand Orofacial Development and Pediatric Health: Learn how early development, including breastfeeding, chewing, and breathing, impacts pediatric health and identify signs that suggest airway and breathing disorders.
• Manage Sleep-Disordered Breathing in Children: Gain insights into the pathophysiology and management of sleep-disordered breathing, emphasizing the role of a multidisciplinary team in treating this condition from infancy through adolescence.
• Highlight Early Interventions and Collaborative Care: Explore the impact of early life interventions and multidisciplinary care on dental and facial development, using case studies to illustrate effective early detection and treatment strategies.

Presenter: Koichi Tanji, ND, LMHC, FMAPS

Title of Talk:Beyond the Screen: Exploring the Link Between Gaming Addiction and Digestive Wellness

Abstract:

In "Beyond the Screen: Exploring the Link Between Gaming Addiction and Digestive Wellness," we delve into the relationship between excessive gaming and digestive health. Gaming disorder, characterized by compulsive and uncontrollable gaming habits, often manifests in various physical symptoms that extend beyond mental health concerns. Commonly, individuals experience significant weight loss, diminished interest in eating, or develop picky eating habits. These symptoms can be accompanied by abdominal pain, discomfort, and a range of other digestive issues.

However, the challenges extend beyond mere symptomatology. Once individuals become deeper into gaming addiction, addressing their dietary and medical needs, which are crucial if they need treatment for their speacial needs, becomes extremely difficult. Compliance with treatment regimens becomes notably challenging, as gaming addiction often engenders a lifestyle marked by irregularities such as sleep inversion and eating habits. This non-compliance exacerbates the already complex task of managing digestive health concerns, further complicating medical intervention.

Understanding the profound interplay between gaming addiction and digestive wellness is essential for healthcare professionals to identify the hidden cause. By shedding light on these connections, we can develop more effective strategies for intervention and support, ultimately promoting holistic well-being in those affected by gaming addiction.

Objectives

• Define gaming addiction and its classification as a behavioral addiction, characterized by compulsive and uncontrollable gaming habits that result in significant impairment in various areas of life.
• Understand the relationship between excessive gaming and its impact on digestive health, including common physical symptoms and complications.
• Identify the signs and symptoms of gaming disorder, beyond mental health concerns, that may indicate underlying digestive wellness issues.
• Explore the challenges associated with addressing dietary and medical needs in individuals with gaming addiction, including barriers to compliance with treatment regimens.
• Recognize the lifestyle irregularities often associated with gaming addiction, such as sleep inversion and disordered eating habits, and their implications for digestive wellness.
• Evaluate the complexity of managing digestive health concerns in individuals with gaming addiction and the importance of tailored intervention strategies.
• Analyze the interplay between gaming addiction and digestive wellness to better understand hidden causes and develop comprehensive treatment approaches.
• Discuss the role of healthcare professionals in identifying and addressing digestive health issues in individuals affected by gaming addiction.
• Develop strategies for intervention and support aimed at promoting holistic well-being in individuals with gaming addiction, with a focus on digestive health management.

Presenter: Myriah Hinchey, ND, FMAPS, Nancy O'Hara, MD, FMAPS, Emily Guiteriz, NP, FMAPS and Mary Saintonge, M.ED

Title of Talk:Setting Up a Practice

Abstract:

Aesthetically & Medically: Building or Enhancing Your Functional Medicine Practice

Join Nancy H. O’Hara, MD, MPH, Myriah Hinchey, ND, Emily Guitterez, DNP, and Mary T. Saint-Onge, M.Ed, CAGS in discussing all of the aspects of setting up a successful functional medicine practice

At many of these functional medicine conferences we discuss how to get to the root causes of illness, but we do not often discuss the HOW TO of setting up that practice in an integrative and functional way.

Nancy O’Hara, MD, MPH, FAAP, FMAPS, Myriah Hinchey, ND, FMAPS and Emily Guitterez, DNP, FMAPS, IFMCP will discuss the medical, legal, practical and functional issues in setting up a practice. Who do I consider adding to my practice? What are the legal recommendations? What are the practical ways to do this?

Mary St Onge, M.Ed., CAGS will discuss the Feng Sui of setting up a practice. First impressions are formed in the first three seconds when walking into a new environment. The senses of sight, smell, sound and touch are on alert and an individual is able to make a judgement based upon that initial view. When you have worked in an office for a while, you become desensitized to all the different elements that belong in the space and forget to take a fresh look at what has been accumulated and arranged in the work environment. Mary will also spend time with you reviewing pictures or videos of your office if you bring them to the conference!

Presenter: Nancy O’Hara, MD, MPH, FAAP, FMAPS

Title of Talk:The Foundations of a Functional Medicine Approach: How to Interpret the Signs, Symptoms and Lab Testing

Abstract:

Nancy O’Hara, MD, MPH, FAAP, FMAPS will discuss all of the signs, symptoms and laboratory testing that should be considered in seeing a child with ASD or other chronic illnesses. Dr. O’Hara will discuss the ways to utilize the history, physical exam and preliminary lab tests to identify the root causes of gastrointestinal, metabolic, mitochondrial and immunologic disorders in children with ASD and other chronic illnesses.

Presenter: Anju Usman Singh, MD, FMAPS

Title of Talk:BIOFILMS, SIBO and SIFO, OH MY

Abstract:

Recent evidence points to the ever-increasing role bacteria and microflora play in affecting our overall health and immune system. Patients with chronic illnesses often have underlying toxicity and persistent infections that lead to ongoing inflammation and symptoms. Many pathogens produce a watery mucous slime known as biofilm, that allows infections to remain persistent and evade the immune system. Dr. Usman Singh will discuss an approach that she has been utilizing for over 15 years to help dissolve biofilms and to improve the host immune response to pathogens. Her 4-step Biofilm Protocol is designed to help re-establish balance in the microbiome so the immune system can do it’s job more efficiently. This strategy has been employed successfully with patients, especially with SIBO(small intestinal bacterial overgrowth) and SIFO (small intestinal fungal overgrowth)

Presenter: James Neuenschwander, MD, FMAPS

Title of Talk:HBOT in the Age of Spikeopathy: A Perfect Pairing?

Abstract:

Objectives

• Define spikeopathy and how this can affect the health of our patients
• Differentiate between spikeopathy caused by the virus and the vaccines
• Review the biochemistry of the impact of spikeopathy
• Discuss the properties of HBOT that can make it an ideal treatment for spikeopathy

Presenter: Sheila Kilbane, MD

Title of Talk:Pediatric Immune Resilience: Healthy Cell, Healthy Gut, Healthy Child
How to Put Theory into Practice - A Universal Approach

Abstract:

A universal approach on how to set the foundations for kids with eczema, asthma, or other inflammatory conditions. We will review the practical aspects of how to identify triggers of inflammation. How to restore digestion and cellular integrity while addressing the skin microbiome and the gut microbiome, controlling histamine, and balancing the immune system (by supporting TH1 and TH2 cells and optimizing vitamin D utilization).

Presenter: James Neuenschwander, MD, ABIM/AAPS, ABIHM, BCEM/AAPS, FMAPS

Title of Talk:Cases in Metabolism

Abstract:

Many of the children I see have issues with mitochondrial function and metabolism. Whether it be a genetic somatic mutation or a mitochondrial dysfunction induced by malnutrition or toxicity. In this presentation, we will review a few cases illustration these issues and show how some of the interventions can lead to improvement in function even in the most severe cases.

Presenter: James Neuenschwander, MD, ABIM/AAPS, ABIHM, BCEM/AAPS, FMAPS

Title of Talk:Biochemical Basis of the Integrative Approach

Abstract:

This whirlwind presentation will cover the biochemistry that underlies the integrative/biomedical approach. We will cover the methylation pathways and how they connect to sulfation and detoxification. We also look at the details fot he gut-brain- immune triad and the impact of gut health on the entirety of heath. We will dive into mitochondrial, its impact on cell signaling, and the importance of the ell danger response. We will look at the chemistry of membrane lipids and foundations of the type and balance of the fats that make up our membranes. Finally, we will look at the impact of toxins on the function of our kids’ physiology. For those of you with a firm grasp of biochemistry, this is a great review, and you will learn something new. For those of you that are new to the integrative approach, this will give you an idea of everything you will learn in our fellowship. By the time we are done, you will have a firm grasp of the biochemical basis of the biomedical approach.

Presenter: Teresa Holler, PA, FMAPS

Title of Talk:Case Presentations - Recovering Health in the Child With PANS and Mycoplasma

Abstract:

Teresa will review a case of a child with PANS. She will discuss the benefits and pitfalls of both conventional and integrative interventions that were attempted to recover her health as well as several flares over the years. She will review the clinical and laboratory findings that helped determine the underlying root causes and triggers and how she managed them. This case will highlight the use of both antibiotic and herbal approaches to the treatment of mycoplasma and candida.

Objectives

• The participant will be able to understand the assessment, diagnosis and treatment of PANS through case study presentation.
• The participant will learn the benefits and pitfalls of steroid and antibiotic use in the management of PANS.
• The participant will become familiar with the integrative management of inflammation, OCD, infections, and more in the setting of PANS.

Presenter: Myriah Hinchey, ND, FMAPS

Title of Talk:The Impact of Mycoplasma Co-infections in Lyme Disease, Autism Spectrum Disorder, and Pediatric Neuropsychiatric Syndromes: Insights and Interventions

Abstract:

This overview encapsulates recent scientific insights into the role of Mycoplasma co-infections in Lyme Disease, its prevalence in Autism Spectrum Disorder (ASD), and its association with Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). Emphasizing the pathophysiology of Mycoplasma infections, this lecture navigates through its intricate involvement across a spectrum of conditions, highlighting its capacity to elude immune detection and exacerbate Lyme Disease symptoms, contribute to neuroinflammatory and neuropsychiatric disorders, and impact gut health and immune regulation in both PANS/ PANDAS and ASD. The dynamic, tick-borne disease landscape reveals Mycoplasma's significant but often underestimated presence, challenging diagnosis and treatment paradigms. Elevated Mycoplasma infection rates in ASD and its potential as a precipitating factor in PANS/PANDAS underscore its pathogenic significance. Addressing these infections necessitates a comprehensive, integrative approach, blending conventional and novel therapies to mitigate Mycoplasma's multi-faceted impact. The lecture, drawing from Dr. Myriah Hinchey's extensive experience, underscores the importance of a tailored, multi-disciplinary strategy to manage and resolve the complex interplay of Mycoplasma co-infections within tick-borne diseases, ASD, and pediatric neuropsychiatric syndromes, paving the way for improved clinical outcomes through personalized care.

The landscape of tick-borne disease (TBD) is dynamic, constantly revealing new insights into its widespread impact. While Lyme disease has traditionally been the primary focus, recent studies have shed light on the significant, yet often overlooked presence of Mycoplasma as a co-infection in TBD and related conditions. Mycoplasma species have pleomorphic morphology rendering them capable of hiding from the immune system while instigating diverse infections, increasing the diversity of clinical presentations. This makes mycoplasma hard to diagnose and difficult to treat (6, 27).

Research indicates that Mycoplasma pneumoniae (the most common species often linked to respiratory ailments) directly invades the CNS, causing neuroinflammatory conditions and exacerbating neuropsychiatric manifestations. This symbiotic relationship underscores Mycoplasma's multifaceted impact on TBD with its ability to trigger or worsen Lyme symptoms (1). M. pneumoniae also emerges as a potential precipitant of acute neuropsychiatric disorders in children, notably pediatric acute-onset neuropsychiatric syndrome (PANS), Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). M. pneumoniae also infects the gut and causes immune dysregulation which in addition to inflammation are highly implicated in Autism Spectrum Disorder (ASD) (10).

Mycoplasma’s Role in Lyme Disease:

Mycoplasmas play an important role in persistent Lyme, contributing to the development, progression, and recurrence of TBDs. Identification of Mycoplasma as a co-infection confirms its significance in concurrent infectious contexts (26). Mycoplasmas affect immune cells and trigger proinflammatory cytokines (as it does in Lyme), contributing to immune modulation and inflammation (25). Lacking cell walls and biosynthetic capabilities, Mycoplasma relies on external nutrient sources, preferring phospholipids and fats in the host environment for survival and proliferation (6, 27). This metabolic strategy enables Mycoplasma to scavenge essential nutrients from cells, aiding its persistence and pathogenicity (25).

Furthermore, Mycoplasma co-infections can manifest symptoms akin to Lyme Disease, including neurological, neurobehavioral, inflammatory, autoimmune, cardiac, vision, facial paralysis, flu-like symptoms including fever, arthritic symptoms, fatigue, muscle and joint pain, GI and urogenital issues, with evidence M. fermentans in CFS patients with Lyme disease (15, 19, 20). Overlapping conditions highlight the complex nature of tickborne illnesses and emphasizes the importance of addressing co-infections for comprehensive management and eventual resolution of TBDs (20).

Mycoplasma and Autism Spectrum Disorder (ASD):

ASD symptoms are associated with brain inflammation and most frequently accompanied by onging mitochondrial dysfunction, immune dysregulation and inflammation commonly manifesting as fatigue, headaches, myalgia, sensory integration issues, and gastrointestinal disturbances as well as a host of other behavioral and developmental issues. Investigation into the prevalence of mycoplasma in ASD reveal its contribution to the etiology, severity, and progression of this complex and increasingly prevalent neurodevelopmental disorder (21).

Chronic tickborne infections, including Babesia, Bartonella, Borrelia, Ehrlichia, and various Mycoplasma strains such as M. pneumoniae and M. fermentans have been implicated in the development of autism spectrum disorders (ASD) (21, 22). Studies consistently demonstrate elevated rates of intracellular bacterial and viral co-infections in patients with neurodegenerative and behavioral disorders such as ASD (21). Research indicates a marked prevalence of Mycoplasma infections in symptomatic ASD patients compared to control groups, suggesting its causal role in ASD pathogenesis (21). Furthermore, familial studies reveal a decreased incidence of Mycoplasma infections in non-symptomatic relatives of ASD patients, highlighting the relevance of Mycoplasma in understanding the etiology and progression of ASD (21).

Mycoplasma and PANS/PANDAS:

The intricate relationship between mycoplasma and other neurodevelopmental disorders like PANS/PANDAS highlights the need for deeper exploration into its pathogenic mechanisms (10, 12). Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) is characterized by the sudden onset of severe obsessive-compulsive disorder and other neuropsychiatric symptoms, typically following infection. Diagnosis involves ruling out similar psychiatric disorders like schizophrenia and ADHD, with PANS standing out for its rapid onset and simultaneous symptom presentation (8, 16). Current research suggests that mycoplasma may serve as an underlying infectious trigger in these conditions, implicating its potential role in neuroinflammation and immune dysregulation (7).

While streptococcal infections are recognized contributors, other infections, including Mycoplasma, have been suggested to influence PANS (23). M., pneumoniae, known for causing respiratory infections, can also lead to neurological manifestations through direct tissue damage, autoimmune processes, and vascular occlusion due to its cytokine-inducing lipoproteins. The autoimmune process in PANS or PANDAS involves neuroactive cytokines like IL-17A and IFN-γ, which serve as inflammatory mediators (2). Emerging research implicates mycoplasma as a potential trigger for neuroinflammation and immune dysregulation in these related conditions (23, 7).

A Comprehensive Approach:

Addressing mycoplasma infections in Lyme disease and tickborne illnesses requires a comprehensive approach involving dietary and lifestyle changes, targeted supplementation, herbal remedies, and gut health (5). Antibiotics commonly used for Lyme disease, such as Doxycycline and Azithromycin, also target mycoplasmas, but integrative therapy is recommended for chronic cases (18). Recent research highlights the impact of additional herbal and naturopathic interventions for tickborne illness and neuropsychiatric manifestations (18).

Optimizing the gut-brain axis and microbiome plays a significant role in improving neuropsychiatric conditions and Mycoplasma (3, 4, 9, 11, 13, 14, 24). Lipid Replacement Therapy (LRT) shows promise in restoring cellular function where mitochondrial dysfunction and reduced ATP production contribute to fatigue and other symptoms in TBDs and mycoplasma (18). Integrating these strategies into clinical practice offers hope for improving outcomes in mycoplasma-associated conditions and informs future research and clinical interventions aimed at addressing these challenges effectively.

Myriah Hinchey, ND, FMAPS, a recognized physician with success in treating complex chronic TBDs for over a decade, will reference her multilayered approach to individualized treatment. Preparing each patient for an optimal therapeutic response to a tick-borne infection requires addressing a complex network of functional deficiencies contributing to an inflammatory milieu that fosters infection. Novel approaches to addressing mycoplasma will provide functional medicine clinicians with an opportunity to guide the course of patients grappling with the effects of mycoplasma by delivering personalized care strategies for these specific disease presentations in both the adult and pediatric populations.

References:

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• 2. Calaprice D., Tona J., Murphy T.K. Treatment of Pediatric Acute-Onset Neuropsychiatric Disorder in a Large Survey Population. J. Child Adolesc. Psychopharmacol. 2018;28(2):92–103. doi: 10.1089/cap.2017.0101.
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• 10. Frankovich, Jennifer, et al. “Five Youth with Pediatric Acute-Onset Neuropsychiatric Syndrome of Differing Etiologies.” Journal of Child and Adolescent Psychopharmacology, vol. 25, no. 1, Feb. 2015, pp. 31–37. DOI.org (Crossref), https://doi.org/10.1089/cap.2014.0056.
• 11. Karlsson F., Tremaroli V., Nielsen J., Bäckhed F. Assessing the human gut microbiota in metabolic diseases. Diabetes. 2013;62(10):3341–3349. doi: 10.2337/db13-0844.
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• 13. Li Q., Zhou J.M. The microbiota-gut-brain axis and its potential therapeutic role in autism spectrum disorder. Neuroscience. 2016;324:131–139. doi: 10.1016/j.neuroscience.2016.03.013.
• 14. Putignani L., Del Chierico F., Vernocchi P., Cicala M., Cucchiara S., Dallapiccola B., Dysbiotrack Study Group Gut Microbiota Dysbiosis as Risk and Premorbid Factors of IBD and IBS Along the Childhood-Adulthood Transition. Inflamm. Bowel Dis. 2016;22(2):487–504. doi: 10.1097/MIB.0000000000000602.
• 15. Maes M, Kubera M, Obuchowiczwa E, Goehler L, Brzeszcz J. Depression's multiple comorbidities explained by (neuro)inflammatory and oxidative & nitrosative stress pathways. Neuro Endocrinol Lett. 2011;32(1):7-24. PMID: 21407167.
• 16. Müller N., Riedel M., Blendinger C., Oberle K., Jacobs E., Abele-Horn M. Mycoplasma pneumoniae infection and Tourette’s syndrome. Psychiatry Res. 2004;129(2):119–125. doi: 10.1016/j.psychres.2004.04.009.
• 17. Narita M. Pathogenesis of neurologic manifestations of Mycoplasma pneumoniae infection. Pediatr. Neurol. 2009;41(3):159–166. doi: 10.1016/j.pediatrneurol.2009.04.012.
• 18. Nicolson, Garth L., et al. “Neurodegenerative and Fatiguing Illnesses, Infections and Mitochondrial Dysfunction: Use of Natural Supplements to Improve Mitochondrial Function.” Functional Foods in Health and Disease, vol. 4, no. 1, Jan. 2014, p. 23. DOI.org (Crossref), https://doi.org/10.31989/ffhd.v4i1.26.
• 19. Nicolson, Garth, et al. “Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme Disease Borrelia Burgdorferi: Evidence for Mycoplasma Species Coinfections.” Journal Of Chronic Fatigue Syndrome, vol. 14, no. 4, June 2008, pp. 5–17. DOI.org (Crossref), https://doi.org/10.1080/10573320802091809.
• 20. Nicolson, Garth L. “Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments.” International Journal of Clinical Medicine, vol. 10, no. 10, 2019, pp. 477–522. DOI.org (Crossref), https://doi.org/10.4236/ijcm.2019.1010041.
• 21. Nicolson, Garth L. “Systemic Intracellular Bacterial Infections (Mycoplasma, Chlamydia, Borrelia Species) in Neurodegenerative (MS, ALS, Alzheimer’s) and Behavioral (Autistic Spectrum Disorders) Diseases.” Townsend Letter Issue , vol. 295, Apr. 2008, pp. 74–84.
• 22. Bransfield, Robert C. “Preventable Cases of Autism: Relationship between Chronic Infectious Diseases and Neurological Outcome.” Pediatric Health, vol. 3, no. 2, Apr. 2009, pp. 125–40. DOI.org (Crossref), https://doi.org/10.2217/phe.09.5.
• 23. Piras C, Pintus R, Pruna D, Dessì A, Atzori L, Fanos V. Pediatric Acute-onset Neuropsychiatric Syndrome and Mycoplasma Pneumoniae Infection: A Case Report Analysis with a Metabolomics Approach. Curr Pediatr Rev. 2020;16(3):183-193. doi: 10.2174/1573396315666191022102925. PMID: 31642785; PMCID: PMC8193809.
• 24. Rachid R., Chatila T.A. The role of the gut microbiota in food allergy. Curr. Opin. Pediatr. 2016;28(6):748–753. doi: 10.1097/MOP.0000000000000427.
• 25. Razin, Shmuel, et al. “Molecular Biology and Pathogenicity of Mycoplasmas.” Microbiology and Molecular Biology Reviews, vol. 62, no. 4, Dec. 1998, pp. 1094–156. DOI.org (Crossref), https://doi.org/10.1128/MMBR.62.4.1094-1156.1998.
• 26. Stricker, R. B., & Johnson, L. (2020). Lyme disease: the next decade. Infection and Drug Resistance, 13, 1.
• 27. Waites, K. B., & Talkington, D. F. (2004). Mycoplasma pneumoniae and Its Role as a Human Pathogen. Clinical Microbiology Reviews, 17(4), 697–728. https://doi.org/10.1128/cmr.17.4.697-728.2004

Objectives

• Pathophysiology of Mycoplasma spp
• Relationship of Mycoplasma in LD, ASD, PANS/PANDAS
• Effective strategies for eliminating Mycoplasma

Presenter: John Gaitanis, MD

Title of Talk:Low Glycemic and Ketogenic Diets and the Brain: Beyond Just Epilepsy

Abstract:

The low glycemic and ketogenic diets have long been used as a treatment for epilepsy. Their mechanism of action is complex with effects on mitochondrial functioning, inflammation, and the gut microbiome. Having a fuller understanding of the diet's physiologic effects is necessary when considering neurological indications beyond epilepsy. The potential role for low glycemic and ketogenic diets in autism and autoimmune neuropsychiatric conditions will be discussed.

Objectives

• Overview of the types of low glycemic diets and how they differ
• Review mitochondrial and inflammatory effects of the ketogenic and low glycemic diets.
• Understand how the benefits for epilepsy will translate to other neurological conditions

Presenter: Sabine Hazan, MD

Title of Talk: Save the Biff

Abstract:

Microbiome taken interest what is the history of the discovery of loss of biff

Objectives

• Understanding the Microbiome
• The importance of bifidobacteria
• Understanding what gut dysbiosis is.

Presenter: Maria Gahry, DNP, RN, FNP, FMAPS

Title of Talk: Setting the Stage: Prenatal & Perinatal Foundations

Abstract:

This lecture will focus on preconception and perinatal concepts that are shown to increase the risk of neurodevelopmental disorders and influence rates of chronic illness rates in children. Topics will include research on immune activation and autoimmunity, the gut microbiome, toxin exposure, the health of the endocrine system including thyroid disorders and medication risk in pregnancy.

Presenter: Maria Gahry, DNP, RN, FNP, FMAPS

Title of Talk: Case Presentations - Integrative Management of Ulcerative Colitis

Abstract:

Case presentation of a female with a diagnosis of UC who is using interventions like probiotics, probiotics and other integrative modalities based on 16sRNA stool testing to rebalance the gut biome and reduce inflammation.

Presenter: Aristo Vojdani, PhD

Title of Talk: Systems immunology approach to long COVID

Abstract:

Systems immunology is a compilation of strategies for measuring a broad range of immunological assays as a powerful way of making the human immune systems more interpretable and understandable as a whole by discovering the relationships between the phenomena, factors, or mechanisms involved in diseases. This is vital for diagnosing and treating long COVID, which, like myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), is a multifactorial disease that cannot be diagnosed by a single laboratory test nor treated with a single medication. Long COVID is now recognized as a separate disorder that follows soon after an initial infection with SARS-CoV-2 and may last for an indefinite period, with a wide range of persisting, returning or even new but related symptoms that involve different tissues and organs, including respiratory, cardiac, vascular, gastrointestinal, musculoskeletal, neurological, endocrine and systemic. Along with this multiplicity of symptoms, there are also several mechanisms that work together to bring about this disease.

Objectives

In this presentation, we will discuss the following topics related to these mechanisms:

• Viral persistence – under certain conditions, viral invaders may not be completely eliminated by the host’s immune system. These viruses may later be reactivated and facilitate and enhance the entry and effects of SARS-CoV-2 into cells
• Reactivation of latent viruses – antibodies for viruses such as EBV, HHV-6 and their dUTPases can be measured to facilitate confirmation of long COVID
• Viral superantigens – molecular chaperones such as heat shock proteins HSP60/HSP90 and their roles in the induction of autoimmunity
• The cytokine Activin-A – a member of the TGF- superfamily, and its relation to superantigen induction and interference of immune function
• Variability in the immune system – inter-individual variation in the immune responses to environmental insults strongly impacts the development of long COVID, therapeutic intervention, and clinical outcome
• Disturbances in the gut – alterations in the microbiome and mycobiome are hallmarks of long COVID, and the measurements of the appropriate members of these communities can be effective biomarkers
• Multiple tissue damage and autoimmunity – Some of the effects of long COVID may be attributable to the molecular mimicry between viruses such as SARS-CoV-2, EBV, HHV-6, and human tissues, such as neuronal cell antigens, leading to neuroautoimmunity and other disorders.

Presenter: Sharon Hausman-Cohen, MD

Title of Talk: The Intersection Between Genomics and the Gut

Abstract:

In This Talk Dr. Sharon Hausman-Cohen will discuss how genetic variants can interact with an individual's diet and environment and how they relate to physical symptoms and diseases such as ASD, environmentally acquired illness, inflammatory and irritable bowel, and PANS.Additionally, she will elucidate how an individual’s genomics can relate to their gut microbiome and how this can contribute to health and chronic issues ranging from depression to ASD.

Objectives

• Be able to describe how an overactive CBS pathway can contribute to ASD risk and mitochondrial dysfunction
• Be able to list 3 genes whose variants can contribute to inflammatory bowel disease
• Understand the role of gut related genomics in autoimmunity including PANS/PANDAS

Presenter: Amy Derksen, ND

Title of Talk: Using Peptide Therapy in Immune Activated Children For Help in Recovery and Better Treatment Tolerance

Abstract:

Peptide therapies are the latest in treatment modalities that have the potential to not just mask symptoms, but to actually repair and correct the damage and dysregulation. There are many options, but there are a few that have been proven to be effective and well tolerated with children on the spectrum. Peptide therapy is safe and can be easy to implement. This lecture will focus on the most helpful we have seen so far, including BPC-157, KPV, Thymogens, Cerebrolysin, Selank and Semax. I will also share research and clinical pearls on use of other immune modulators and anti-inflammatories that have proven helpful when symptoms are flared and things feel desperate.

Objectives

• The goal of this lecture is for you to be able to confidently implement peptide therapy in your practice as soon as you return to the office.
• To provide dosing strategies and safety concerns, as well as how to educate your patients on these therapies.
• To have more tools in your arsenal to help calm down symptoms and turn things around in the more difficult cases.

Presenter: Jeff Thurston

Title of Talk: *4^th Course - Optimizing Dietary and Digestive Health: Exploring the Roles of Minerals, Probiotics, and Systemic Enzymes

Abstract:

It is not only what you eat but what you digest. Then what you assimilate and eliminate matters. Finally, systemic enzymes can help manage those leaky gut proteins. In the realm of nutrition and digestive health, the significance of minerals, probiotics, and systemic enzymes cannot be overstated. This talk delves into the crucial roles these elements play in promoting overall well-being. Minerals are essential micronutrients vital for various bodily functions, including bone health, muscle contraction, and nerve transmission. Furthermore, they act as cofactors for enzymatic reactions, underscoring their indispensability in cellular metabolism. Probiotics, on the other hand, are beneficial bacteria that inhabit the gut, fostering a symbiotic relationship with the human body. Their specificity in strain selection and targeted delivery ensures optimal gut flora balance, bolstering immune function, digestion, and nutrient absorption. Lastly, systemic enzymes function as catalysts for biochemical reactions, facilitating processes such as inflammation modulation and tissue repair. Understanding the interplay between minerals, probiotics, and systemic enzymes offers valuable insights into optimizing dietary and digestive health strategies, ultimately contributing to enhanced overall wellness.

Presenter: Heather Way, PhD

Title of Talk: Gut Feelings: Demystifying the ASD/IBS Microbiome

Abstract:

Dr Way will discuss some of the findings from her ongoing IBS and ASD microbiome sequencing research including:

The markedly depleted diversity that we see in the ASD microbiome.

What overgrowths are important to know about.

What species are missing (this is functionally just as significant).

The most reduced genera in the ASD biome and what important roles they perform. (Spoiler alert, one contributes to the first stages of heavy metal breakdown).

The PANDAS / microbiome connection, which species are correlated with anti-streptolysin O titre? (Spoiler alert, it’s not just Strep).

The gut bacteria / Vitamin D link in ASD.

ASD severity is associated with a reduction in SCFA’s, particularly butyrate, modulated by specific gut microbes (which are often missing).

Dr Way will share her research based, practical strategies, proven to replace the missing microbiota, restore a healthy gut and reduce ASD and ADHD symptoms including:

• Which probiotic strains, prebiotics, gut healing agents and mitochondrial support to use in which circumstances.
• How and why fermented foods and prolonged fermentation times yield more microbes and far greater benefits than taking probiotic capsules.
• Knowing what species are missing, helps guide treatment protocols for constipation and diarrhoea.
• When is Vagus nerve stimulation an appropriate key to improving gut health?
• What to do during and after antibiotic therapy to recover the gut quickly.
• Using metagenomics to guide treatment strategies.

Objectives

• What are the fundamental differences between the Autism gut and the neurotypical gut?
• How can the gut be modulated to help with PANS / PANDAS, and other pathogen control?
• How can metagenomics be used to help children with neurological disorders?

Presenter: Liz Mumper, MD, FAAP, FMAPS

Title of Talk: The Foundations of Biomedical Thinking

Abstract:

Frequently, we are not aware of our thought process; and this can get in the way of appropriately managing our patients. In this presentation, we will identify the key differences in the thought process behind the biomedical approach versus our standard medical model. Understanding the interconnectedness of our systems and how manipulating one thing in one system can impact the entire body. We will investigate how to change the thought process when we approach our patients. As Dr. Sid Baker once said, "If you are having problems answering a question about how to treat a patient, maybe you are asking the wrong question."

Presenter: Michelle Perro, MD, DHom

Title of Talk: *4^th Course - Pediatric Pitfalls: Pivoting for Success in Clinical Practice

Abstract:

As a practitioner, what do you do when cases go unresolved with standard treatments? Do you ever feel frustrated when conventional options don’t result in the outcomes you anticipated when you chose this profession?

Dr. Michelle Perro, MD, DHom, a respected physician with over 40 years of experience in pediatric care, has encountered her fair share of confounding cases. She has approached puzzling patients with an open mind and curiosity. That, coupled with a deep commitment to finding solutions, has led her to initiate change in her methods and develop innovative new approaches that work. Please join her as she highlights cases that illustrate some of the invaluable lessons and tools she now utilizes regularly.

Presenter: Christine Saba, MD, Pharm.D

Title of Talk: Obestiy Pandemic: Gut Health/Infections/Genetics

Abstract:

The inter relationship between gut health ,genetics and the impact of infections towards obesity

Objectives

• Learn the role of infections and the mechanism of weight gain due to infectious agents
• What is the interplay of gut health, immune system and infectious agents
• What factor does genetics have in this milleu

Presenter: Piper Dobner, NMD, MS

Title of Talk: Microbiome Restoration: From Fecal Transplants to Human Hookworms

Abstract:

I am a physician who is deeply involved in the study of microbiome restoration. My journey started with fecal transplants, which is a groundbreaking therapy that has helped us to understand the delicate balance of the gut microbiota. Through fecal transplants, I have seen firsthand the profound impact that microbiome diversity can have on overall health and immune function. The therapy has been particularly effective in treating C.diff and other comorbidities, and has resulted in significant improvements in a very short span of time. Overall, this therapy has taught me a lot about the importance of microbiome diversity and its role in maintaining good health.

I conducted an extensive exploration and analysis on the use of sterilized stool as a means of restoring microbial balance in the body. This approach eliminates the risk of infectious diseases that are associated with traditional fecal transplants. During my research, I discovered postbiotics, which have become one of my preferred methods of microbiome restoration. Poop is my passion and better understanding the microbiome through this lens has led me to explore the significant impact of human hookworms on immune modulation and gut health.

These keystone species act as a profound opportunity for microbiome restoration. The therapy has offered unique insights into immune regulation and the treatment of various autoimmune conditions. Witnessing this microbiome-mediated immune modulation has been both awe-inspiring and humbling.

These experiences have highlighted the importance of viewing the internal environment as an ecosystem. The microbial diversity in this ecosystem plays a vital role in promoting longevity and optimal health. By embracing the power of the microbiome, we can transform the way we approach healthcare. We should focus on treatments that aim to restore balance within this intricate ecosystem, as well as all of the unique ecosystems that we are in relationship with.

I am passionate about sharing my insights with other healthcare providers, because I firmly believe that understanding the microbiome's role in immune modulation is essential for improving patient care and promoting overall well being.

Come and explore the intriguing realm of microbiome restoration with me, where microbial communities tell stories of resilience, adaptation, and the remarkable capacity for healing.

Objectives

• Understand the Impact of Microbiome Diversity on Health: Attendees will be able to explain the significance of microbiome diversity in maintaining overall health and immune function, with a particular focus on the role of fecal transplants in treating conditions like C. diff and other comorbidities.
• Explore the Role of Microbiome in Immune Modulation and Autoimmune Disease Treatment: Attendees will learn about the significant impact of the microbiome on immune modulation and the treatment of autoimmune diseases, focusing on the therapeutic potential of microbiome restoration techniques.
• Recognize the Role of Keystone Species in Immune Modulation: Attendees will gain insights into how keystone species, such as human hookworms, contribute to immune regulation and the treatment of autoimmune conditions, emphasizing the broader implications of viewing the internal environment as an ecosystem for promoting longevity and optimal health.

Presenter: Kristine Gedroic, MD

Title of Talk: Advances in Microbiome Sciences

Abstract:

The microbiome refers to the diverse community of microorganisms that inhabit the human body, playing crucial roles in health and disease. Understanding what constitutes a healthy microbiome involves examining the balance and diversity of microorganisms residing within different body niches. Key factors influencing a healthy microbiome include diet, lifestyle, genetics, and environmental exposures. Microbiota signatures are distinctive patterns of microbial composition and activity associated with specific health conditions or stages. Research has unveiled microbial signatures linked to conditions such as obesity, inflammatory bowel disease, and even mental health disorders. Identifying these signatures provides valuable insights into disease mechanisms, diagnostic markers, and potential therapeutic targets. Advances in microbiome research have led to innovative strategies for manipulating microbial communities. Probiotics, prebiotics, and symbiotic are among some the techniques utilized to modulate the microbiome. Successful manipulation of the microbiome has shown promise in treating conditions like Clostridioides difficile infection, inflammatory bowel disease, and metabolic disorders. In conclusion, our exploration of the microbiome has illuminated its pivotal role in human health and disease. By defining what constitutes a healthy microbiome, uncovering microbiota signatures of significance, and discussing successful manipulation techniques, we are poised to harness the therapeutic potential of this intricate ecosystem for the benefit of individuals worldwide.

Objectives

• To define a healthy microbiome
• To explore microbiota signatures of significance
• To discuss the successful manipulation of the microbiome

Presenter: Daniel Stein, MD

Title of Talk: Toxicant Exposure in the Pediatric and Young Adult Population; Sources, Adverse Health Outcomes, and Treatment Strategies

Abstract:

Our children are bombarded with toxicants starting in utero, continuing during breast or formula feeding and extending through childhood and adolescence from exposures in water, food, toys, clothing, house hold items, medical procedures and the ground and even air we breathe. These toxicants have well established adverse health consequences in terms of neural, behavioral, hormonal, immunologic and overall healthy development. Importantly, many of these adverse consequences flow from toxicant impacts on the developing and maturing microbiome with secondary adverse effects noted. This lecture will provide a review of the various toxicant classes and their major deleterious impacts, and we will discuss when and where they have an impact on the GI tract to induce dysbiosis.

Objectives

• Review the most common and/or significant toxicant classes, their routes of exposure and their effects on body systems in the pediatric population
• Identify which toxicants and the mechanism by which they induce dysbiosis
• Review approaches to detecting toxicant exposures
• Briefly review approaches to exposure prevention, and detoxification strategies appropriate for the pediatric population.

Presenter: Larry Palevsky, MD

Title of Talk: Practical Strategies for Evaluating & Treating Children Diagnosed with ADD/ADHD

Abstract:

According to the CDC, approximately 1 in 9 US children have ever received a diagnosis of ADHD, (11.4% or 7.1 million children ages 3-17), and 10.5% (6.5 million) have a current diagnosis of ADHD. ¹ These data were calculated from the 2022 National Survey of Children’s Health. Among children with a current diagnosis of ADHD, 58.1% had moderate or severe ADHD, and 77.9% had at least one co-occurring disorder. In contrast, in 2016, 9.9% of children had ever received a diagnosis of ADHD, and only 8.9% of children had a then-current diagnosis of ADHD.

One of the earliest descriptions of symptoms similar to what we currently describe as ADHD, was noted by Sir Alexander Crichton, a Scottish physician, in 1798.

The incapacity of attending with a necessary degree of constancy to any one object, almost always arises from an unnatural or morbid sensibility of the nerves, by which means this faculty is incessantly withdrawn from one impression to another. It may be either born with a person, or it may be the effect of accidental diseases.

When born with a person it becomes evident at a very early period of life, and has a very bad effect, inasmuch as it renders him incapable of attending with constancy to any one object of education. But it seldom is in so great a degree as totally to impede all instruction; and what is very fortunate, it is generally diminished with age.²

Some studies, however, indicate about 50% of children diagnosed with ADHD may retain symptoms of ADHD into adulthood.³ Crichton went on to state that the incapacity of attending, if not innate, can also be caused by nervous disorders.

In this disease of attention, if it can with propriety be called so, every impression seems to agitate the person, and gives him or her an unnatural degree of mental restlessness. People walking up and down the room, a slight noise in the same, the moving a table, the shutting a door suddenly, a slight excess of heat or of cold, too much light, or too little light, all destroy constant attention in such patients, inasmuch as it is easily excited by every impression. The barking of dogs, an ill-tuned organ, or the scolding of women, are sufficient to distract patients of this description to such a degree, as almost approaches to the nature of delirium. It gives them vertigo, and headache, and often excites such a degree of anger as borders on insanity. When people are affected in this manner, which they very frequently are, they have a particular name for the state of their nerves, which is expressive enough of their feelings. They say they have the fidgets.⁴

Today, a close description of Dr. Crichton’s observations of children who we diagnose with ADHD can be found in the DSM-V. ADHD is usually diagnosed by a trained healthcare provider when six or more symptoms of inattention and/or hyperactivity-impulsivity are present for 6 months for children up to age 16 years, and are inappropriate for their developmental level or, five or more symptoms of inattention and/or hyperactivity-impulsivity are present for 6 months for adolescents ages 17 older and adults, that are inappropriate for their developmental level.⁵

In today’s world, there is no single test to diagnose ADHD, and many other problems, such as sleep disorders, anxiety, depression, and certain types of learning disabilities, can also have symptoms similar to ADHD. ⁶

The National Survey of Children’s Health from 2022 revealed approximately half of children with current ADHD (53.6%) received ADHD medication, and 44.4% had received behavioral treatment for ADHD in the past year (to include parent-delivered behavior therapy, social skills training, peer interventions, and cognitive behavior therapy); nearly one third (30.1%) did not receive any ADHD-specific treatment.⁷

When it comes to understanding causes and contributing factors to the development of ADHD in children, there is great focus on the genetics of attention deficit disorder. "Decades of research show that genes play a vital role in the etiology of attention deficit disorder and its comorbidity with other disorders. Family, twin, and adoption studies show that ADHD runs in families." Little effort is spent in 8 mainstream medicine, however, to try to understand a broader cause to the rise in cases of ADHD in children.

Attention deficit hyperactivity disorder (ADHD) is a condition presenting with symptoms of inattention and hyperactivity. Often, children with inattentive symptoms have trouble focusing, paying attention, staying on task, following through on instructions, and organizing tasks & activities. They are easily distracted, usually disorganized, and hesitant to engage in tasks that require prolonged mental effort. They are frequently forgetful in daily activities, easily lose things, and have trouble with overall executive function.

Often, children with inattention, who also present with hyperactivity, have a tremendous amount of involuntary muscle movements. They just can’t help themselves from moving, fidgeting, and being on the go. They are usually restless, and are simply unable to sit still and stay still. They can be impulsive, interrupt and intrude on others, become very excited and reactive, throw more temper tantrums, and often talk excessively, and loudly.

Let’s take a step back for a second and address the following:

What part of the brain is activated to help children develop the skills to focus, pay attention, stay on task, follow-through, organize, engage in prolonged mental effort, and invoke executive brain function? The cerebrum, or frontal cortex (forebrain).

Similarly, what part of the brain is activated to drive the increase in involuntary muscle movements associated with hyperactivity? Where there is an inability to sit still and stay still? Where there is restlessness, fidgeting, excessive talking, excitement, impulsivity, reactivity, temper tantrums, and even aggression? And, where excess involuntary movements makes these children develop a dislike of reading, and/or an inability to read, and trouble with reading retention and comprehension, and bad penmanship. The hindbrain, predominantly the cerebellum and medulla.

Children with inattention and/or hyperactivity have accelerated cerebellum and medulla (hindbrain) activity and reduced cerebrum, or frontal cortex (forebrain) activity. Accelerated hindbrain activity means elevated adrenaline and dopamine levels. Reduced cerebrum, or frontal cortex/forebrain activity, means reduced acetylcholine levels. In the face of elevated adrenaline and dopamine levels, sympathetic tone is increased. In the face of reduced acetylcholine levels, parasympathetic tone is reduced.

Physiologically, when cerebellum and medulla activity, along with sympathetic tone, are increased, there is increased blood flow to the hindbrain. When cerebrum activity and parasympathetic tone are decreased, there is decreased blood flow to the forebrain. Essentially, sympathetic tone and parasympathetic tone cannot be elevated at the same time. One takes a back seat to the others’ dominant activity. It stands to reason then, that hindbrain and forebrain activity cannot co-exist! Try running out of a burning building (hindbrain) and focus on reading a book (forebrain) at the same time!

The strategy in caring for children with inattention and/or hyperactivity, therefore, is to reduce sympathetic tone and adrenaline and see, as a direct result, a reduction in the stimulation of the cerebellum and medulla, while physiologically increasing parasympathetic tone and acetylcholine which will increase blood flow to the forebrain and reduce inattention.

There is a long list of items I can suggest that contribute to reducing sympathetic tone, adrenaline, and stimulation of the cerebellum and medulla that will automatically allow for increased parasympathetic tone and acetylcholine, and increased blood flow to the forebrain.

In this lecture, I will focus on evaluating and modifying many of the inflammatory dietary, lifestyle, and medical choices to which we subject our children in their daily lives, so we can better awaken their forebrain activity without resorting to pharmaceutical treatments.

For many, it’s as simple as figuring out their food allergies and modifying their diets accordingly. We can go all the way back to the Feingold diet for starters. For others, it’s about identifying, and then reducing, the environmental exposures that directly inflame their visual centers (read cerebellum) and their medullas. For countless others, simply being able to understand the potential for these children to have problems with monocular vision or even double vision, and not binocular vision as is necessary for optimal learning, is essential for suggesting the right referral to help them regain cerebellar and forebrain function.

For still others, it’s as simple as realizing that once they are sleeping peacefully through the night, their symptoms of inattention and hyperactivity improve dramatically. In fact, the evaluation of these children for sleep, sleep habits, airway patency, airway size, tongue size and position, and the size of the nasal turbinates, adenoids, and tonsils, is essential when caring for children with inattention and hyperactivity.

I will review practical strategies to help attendees better evaluate and treat children who have been given the diagnosis of inattention and/or hyperactivity, leaving you with practical tools for asking the right questions in the history, focusing on more specifics of the physical exam, and coming up with the appropriate treatment strategies specific to each child. See you there!

_________________

¹https://www.tandfonline.com/doi/full/10.1080/15374416.2024.2335625

²https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000907/

³https://pubmed.ncbi.nlm.nih.gov/16790695/

⁴https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3000907/#CR49

⁵ https://www.cdc.gov/adhd/diagnosis/index.html

⁶ https://www.cdc.gov/adhd/diagnosis/?CDC_AAref_Val=https://www.cdc.gov/ncbddd/adhd/diagnosis.html

⁷ https://www.cdc.gov/adhd/data/?CDC_AAref_Val=https://www.cdc.gov/ncbddd/adhd/data.html

⁸ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6477889/

Objectives

• Attendees will learn new ways to evaluate children diagnosed with ADD/ADHD.
• Attendees will learn new strategies to help support children diagnosed with ADD/ADHD.
• Attendees will learn to understand the brain physiology in children diagnosed with ADD/ADHD.
• Attendees will come to understand that children diagnosed with ADD/ADHD experience significant autonomic dysfunction.
• Attendees will learn the importance of stabilizing autonomic dysfunction in these children, while identifying factors that contribute to the destabilization of their autonomic function.
• Attendees will come to understand how identifying, addressing, and modifying the factors that contribute to the destabilization of autonomic function in children diagnosed with ADD/ADHD can drastically improve their symptoms without pharmaceutical intervention.

Presenter: Myriah Hinchey, ND, FMAPS

Title of Talk: Foundations of Immune Dysfunction: Why are Our Kids So Sick?

Abstract:

The rising incidence of chronic illnesses in children, particularly those involving the immune and neurological systems, poses a growing concern. This presentation will delve into the normal functioning of the immune system, the pathophysiology of inflammatory changes, and immune dysregulation observed in Lyme disease, as well as in Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS). Understanding these mechanisms underscores the critical need to restore immunocompetence for effective patient recovery.

The immune system is a sophisticated network of cells, tissues, and organs that collaborate to defend the body against harmful pathogens. It is composed of the innate and adaptive immune responses. The innate immune system acts as the first line of defense, offering immediate, non-specific protection. In contrast, the adaptive immune system provides a targeted, long-term defense through the activity of T and B lymphocytes. This coordinated immune response is essential for maintaining the body's homeostasis and preventing disease.

In Lyme disease, there is a significant disruption of normal immune function. Lyme causing Borrelia spp. provoke chronic inflammation and immune dysregulation, leading to a cascade of immune responses that fail to eliminate the pathogen effectively. Persistent infection results in continuous inflammation, immune dysregulation, tissue damage, and a range of neurological and systemic symptoms.

PANS and PANDAS present a similar and equally concerning immune challenge. In addition to the inflammatory response and immune dysfunction, there is an underlying mechanism involving an autoimmune reaction where antibodies wrongly target the basal ganglia, a brain region crucial for motor control and behavior, leading to significant neuroinflammation and a variety of neuropsychiatric symptoms.

The path to recovery for children affected by these conditions lies in managing the inflammatory cytokine cascade and ultimately restoring their immunocompetence. Effective immune function is essential not only for overcoming the initial infection but also for breaking the cycle of chronic inflammation and autoimmunity. Addressing the root causes of immune dysregulation and implementing strategies to support and normalize immune responses are crucial steps in the treatment and long-term recovery of these patients.

Presenter: Anju Usman Singh, MD, FMAPS

Title of Talk: Case Presentations - Apraxia and OCD

Abstract:

What would you do? Dr. Singh will review a 10 yr old new patient with ASD, apraxia, and OCD.

What information is helpful? What are you looking for on a physical to give you clues? What labs would you order?

What is your differential diagnosis? This session will be interactive and Dr. Singh will help guide you to determine your next steps in creating a plan to help this patient.

Presenter: Jim Adams, PhD

Title of Talk: Microbial Metabolites and Microbiota Transplant for Autism

Abstract:

Our latest research has revealed that over 90% of children with non-genetic ASD have unusually high levels of one or more of 32 microbial metabolites (levels above that of any typical child). These 32 metabolites are all microbial modifications of tryptophan or phenylalnine/tyrosine, and disrupt their associated functions including serotonin and dopamine pathways. One example is p-cresol, which is known to be harmful to the gut, brain, kidneys, mitochondria, and immune system. P-cresol also correlates with the severity of ASD, and administering it to animals causes autistic symptoms. We propose that this group of ASD children be classified as a new phenotype, ASD-Microbial Metabolite Associated (ASD-MMA), defined by unusually high levels of one or more of 32 microbial metabolites.

We will also present an update on our latest studies of Microbiota Transplant Therapy, which has been demonstrated to reduce levels of p-cresol to normal. This includes a summary of the results of several studies of MTT, our two new studies, and the formation of our new company, Gut-Brain-Axis Therapeutics, which is funded by 50+ autism families to support clinical trials of MTT for autism so that we can achieve FDA approval.

Objectives

• Learn about microbial metabolites that are elevated in autism and how they affect symptoms
• Learn about a new ASD phenotype, ASD-Microbial Metabolite Associated (ASD-MMA)
• Learn about the latest clinical trials of Microbiota Transplant Therapy

Presenter: Star Edwards, MS, RDN/LD

Title of Talk: Missing Bifidobacterium in Children and Strategies for Restoration

Abstract:

The gut microbiome in the first 1,000 days plays a critical role in human health and lifelong immune development. Existing literature supports that gut dysbiosis in this phase of life can increase the risk of developing inflammatory, immune-mediated, metabolic and neurological conditions later in life. One of the key commensal taxa that is increasingly depleted in the western industrialized world – primarily from overuse of antibiotics and modern lifestyle changes - are Bifidobacterium. It is especially alarming when a recent paper showed that B. infantis, a key infant gut symbiont, is missing in 90% of infants across the United States.

This presentation will provide a walkthrough of Bifidobacterium's essential role in an infant’s developing microbiome, factors that contribute to this disappearing microbe, the connection between missing Bifidobacterium and the rise of chronic conditions, and finally highlighting strategies for restoration, showcasing successful case studies in clinical practice.

Microbiome analysis utilizing whole metagenomic sequencing (WMS, also known as shotgun metagenomics) is an innovative tool in understanding the microbiome’s role in a child’s developing gut microbiome. WMS technology allows for detailed characterization, functional profiling, and probiotic/pathogenic strain tracking of the microbiome in the human gut. Paired with Artificial Intelligence (AI), WMS allows for the creation of microbiome evaluations and potential predictive biomarkers for a wide array of clinical outcomes from atopic march conditions in early life, to behavioral and mental health conditions later in life. Attendees will also learn how this tool can be used for detection of missing Bifidobacterium and if restoration was successful and persists. Recolonization methods are possible in older children and even adults.

Objectives

• Why specific strains of bifidobacterium are key to an infant's developing immune system in early life and lack thereof presents chronic health risks
• Biomarkers of pediatric chronic and developmental conditions as a result of missing or low bifs
• Strategies for restoring pediatric gut during and after antibiotic treatment, which is a prevalent method for treating ear infections today
• Why not all probiotics are equal and why prebiotics play an essential role in recolonizing missing beneficial bacteria
• Is there a risk of probiotic over supplementation for infants and what are its repercussions? Why it's important to understand that different probiotic strains have different functions
• Case study: clinical evidence of improved health outcomes with restoration of bifs

Presenter: Tom Moorcroft, DO

Title of Talk: Unraveling Metabolic Endotoxemia: LPS as the Nexus in Lyme, Mycotoxins, and PANS – A Biomedical Approach to the Gut-Brain-Heart Axis

Abstract:

This presentation delves into the pivotal role of metabolic endotoxemia, with a particular focus on Lipopolysaccharides (LPS), as a common denominator in Lyme disease, mycotoxin exposure, and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). We will explore the intricate interplay between the gut and immune function, examining how these disease states impact each other and disrupt gut homeostasis. This disruption extends its influence to the brain and heart, creating a self-perpetuating cycle of inflammation and dis-ease.

Our discussion will illuminate how a comprehensive biomedical approach can significantly enhance patient outcomes. By addressing the gut-brain-heart axis, we aim to provide clear therapeutic action steps and considerations for clinical practice. The presentation will cover key inflammatory molecules such as LPS and lipoproteins, along with the phenomenon of dysbiosis, underscoring their prevalence across these disease states. Attendees will gain a deeper understanding of the interconnectedness of these conditions and the critical role of gut health in breaking the cycle of chronic illness.

Join us to uncover how targeted biomedical interventions can restore balance to the gut-brain-heart axis, offering hope and improved health for patients grappling with these complex, interrelated conditions.

Presenter: Anju Usman Singh, MD, FMAPS

Title of Talk: Foundations of Gastrointestinal Dysfunction: Mind the Gut

Abstract:

In this presentation, I explore the crucial roles and impacts of prebiotics, probiotics, and biofilms on gastrointestinal (GI) health and dysbiosis. The human gut microbiome, composed of around 160-200 predominant species, is unique to each individual, significantly influencing various aspects of health, including immune function, mental health, and metabolic processes. I emphasize the importance of maintaining a balanced gut microbiome to prevent and manage conditions such as allergies, asthma, autoimmune diseases, depression, anxiety, and obesity.

A key focus is on the gut bacteria's ability to synthesize neurotransmitters like dopamine and serotonin, which have profound effects on mental health and behavior. Probiotics, particularly Lactobacillus and Bifidobacterium species, are highlighted for their critical roles in promoting beneficial microbial activity, enhancing immune function, and preventing pathogen overgrowth. Additionally, prebiotics, mainly non-digestible fibers, support the growth of these beneficial bacteria and contribute significantly to overall gut health.

I also address the challenges posed by dysbiosis and biofilms. Dysbiosis, an imbalance in the gut microbiome, can lead to a multitude of health issues. Managing dysbiosis involves restoring microbial balance through dietary adjustments, probiotics, prebiotics, and targeted antimicrobial treatments. Biofilms, which are protective matrices formed by microbial communities, complicate the treatment of chronic infections and require specialized strategies for their disruption and management.

In conclusion, integrating prebiotics, probiotics, and targeted treatments for dysbiosis and biofilms is essential for maintaining optimal GI health and overall well-being.

Presenter: John Gaitanis, MD

Title of Talk: Foundations of Neurology: Our Brains on Fire

Abstract:

In this presentation, Dr. John Gaitanis provides an in-depth analysis of autism from a neurologist's perspective, emphasizing the critical importance of localization in diagnosis. The presentation explores how different neurological pathways and regions, such as the cortex, white matter, basal ganglia, and cerebellum, contribute to the diverse presentations of autism. Dr. Gaitanis discusses the characteristics and associated conditions of various autism subtypes, including intellectual disability, seizures, psychiatric comorbidities, and motor disturbances. Additionally, the session examines the interplay between autism and epilepsy, with a focus on the role of inter-ictal spikes and their impact on language and cognitive regression. This comprehensive approach offers valuable insights into the neurological underpinnings of autism, guiding better diagnostic and therapeutic strategies

Presenter: Dan Rossignol, MD, FMAPS

Title of Talk: Foundations Of Metabolic And Mitochondrial Dysfunction: How These Systems Affect Our Brains

Abstract:

Dr. Dan Rossignol will discuss the evidence suggesting that some metabolic abnormalities, like mitochondrial dysfunction and CFD, might lead to potentially reversible autism symptoms if identified and treated early. The presentation highlights ASD as a complex neurodevelopmental disorder with biological underpinnings, showing characteristics of known medical disorders rather than being solely psychiatric.

The session will delve into mitochondrial disease subtypes, both primary and secondary, and their connections with ASD symptoms. These include developmental regression, motor delays, seizures, and gastrointestinal issues, all linked to mitochondrial dysfunction. Additionally, Dr. Rossignol will cover specific biomarkers for mitochondrial dysfunction and CFD, alongside a review of diagnostic methods for identifying these conditions. The role of oxidative stress, immune dysregulation, and potential maternal and early-life mitochondrial abnormalities will be presented, along with treatment approaches, such as folinic acid for CFD, which have shown promise in improving verbal communication and behavior in ASD.

Presenter: Julie Matthews, MS

Title of Talk: The Foundations of Nutrition: You Are what You Eat

Abstract:

In this presentation, Julie Matthews, MS, delves into the critical role of nutrition in managing neurodevelopmental disorders such as autism, ADHD, and anxiety. The session highlights the profound impact of diet on brain function, the gut microbiome, and overall health. Matthews emphasizes the necessity of a personalized nutrition approach, tailored to the unique needs of each individual, to address the underlying factors contributing to these disorders. The presentation explores the benefits of therapeutic diets, the negative consequences of unhealthy food choices, and the importance of an organic, nutrient-dense diet. Attendees will gain insights into how specific dietary interventions can influence behavior, cognition, and overall well-being in children with neurodevelopmental challenges. Through evidence-based strategies, Matthews provides practical guidance for implementing dietary changes that can significantly improve health outcomes.

Presenter: Ari Calhoun, ND

Title of Talk: The Autism Microbiome: Signatures and Solutions

Abstract:

In this presentation, Dr. Ari Calhoun, N.D., explores the intricate relationship between the gut microbiome and autism spectrum disorder (ASD). Drawing on the latest research and clinical insights, Dr. Calhoun discusses the unique microbial signatures associated with ASD and the potential impact of these microbes on neurodevelopmental health. The presentation emphasizes the importance of personalized precision medicine, highlighting innovative strategies for formulating patient-specific probiotic treatments that address the distinct microbiome imbalances found in individuals with ASD. Attendees will gain a deeper understanding of how targeted probiotic supplementation can improve gastrointestinal health, reduce inflammation, and enhance overall well-being in neurodiverse individuals. This session is essential for clinicians seeking to incorporate cutting-edge microbiome therapies into their practice to support the health and development of patients with ASD.

Presenter: Michael Elice, MD, FMAPS

Title of Talk: Case Presentations

Abstract:

In this detailed case study, Dr.Elice presents the complex journey of Milo, a 9-year-old boy diagnosed with autism spectrum disorder (ASD), seizures, and aggressive behavior. This presentation explores the evolution of Milo’s symptoms from infancy, highlighting his developmental challenges, including speech regression, sleep disturbances, and clumsiness. The lecture delves into the genetic and metabolic factors contributing to his condition, focusing on the role of specific genetic mutations (e.g., MTHFR, ANKK1, GCLC) in his neurodevelopmental and metabolic dysregulation. Through a personalized treatment plan informed by advanced genomic analysis, Dr. Elice discusses targeted interventions, including mitochondrial support, detoxification strategies, and neurotransmitter modulation, which have led to significant improvements in Milo's behavior, seizure control, and overall well-being. This case study underscores the importance of integrating genomics into the management of complex neurodevelopmental disorders, offering valuable insights for clinicians seeking to tailor treatments to the unique needs of their patients.

Presenter: Lindsey Wells, ND, FMAPS

Title of Talk:Case Presentations

Abstract:

This presentation delves into the application of integrative medical approaches in treating pediatric neurodevelopmental disorders, specifically focusing on two case studies involving PANS/PANDAS and Autism Spectrum Disorder (ASD). The first case study highlights a 17-year-old male with severe Obsessive-Compulsive Disorder (OCD) exacerbated by PANDAS. Despite previous treatments, including antibiotics and IVIG, the patient experienced recurrent symptoms and increased sensitivity to interventions. The introduction of a gluten- and casein-free diet coupled with folinic acid supplementation led to marked improvements in OCD symptoms, anxiety, and overall well-being.

The second case study explores the treatment of a 3-year-old male with developmental delays and ASD, emphasizing the challenges of early diagnosis and intervention. This case demonstrates the benefits of dietary modifications and targeted supplementation, including folinic acid and B12, in improving speech, eye contact, and social engagement.

Through these case studies, the presentation underscores the importance of personalized treatment plans that address underlying biochemical and immunological imbalances. The results suggest that dietary interventions and nutrient supplementation can play a pivotal role in managing complex pediatric conditions like PANS/PANDAS and ASD, offering hope for improved outcomes in affected children.

Presenter: Erica Peirson, NMD

Title of Talk: Supporting Cognition and Brain Health in Down Syndrome

Abstract:

Historically, poor cognition and health in individuals with Down syndrome were often accepted as inevitable, with limited interventions aimed at improving their quality of life. This passive approach led to missed opportunities for cognitive and physical development. Recent advances in understanding the biological, metabolic, and environmental factors affecting individuals with Down syndrome highlight that actionable steps can be taken to improve their health and cognition. These include addressing gut health, malabsorption, B vitamin deficiencies, supporting mitochondrial function and using compounds like EGCG to modulate gene expression. A functional medical approach recognizes the phenotypic variability among individuals with Down syndrome by addressing their unique biochemical, genetic, and environmental factors that influence their health. With high expectations and personalized care, individuals with Down syndrome can experience substantial improvements in their overall well-being. This multi-faceted approach offers a comprehensive framework for supporting cognition and brain health in individuals with Down syndrome

Objectives

• Explore the mechanisms of genetic overexpression in Down syndrome, particularly how trisomy 21 influences cognitive development
• Discuss common gastrointestinal issues in Down syndrome, such as malabsorption, and their potential impact on brain health and cognitive function
• Review specific nootropics that can enhance cognition and memory in Down syndrome

Presenter: Rebecca Sherry Eshraghi, PhD

Title of Talk: Pathway: From Transgenerational loss of Microbes to Inflammation, to BBB Disruption to Brain Injury or How the Transgenerational Loss of Microbes is Fueling the Autism Epidemic

Abstract:

We are witnessing an exponential rise in the number of neurological conditions out of which the majority can be traced to imbalances in the microbiome. This steady rise may well be the consequences of losing crucial microbes over generations, making our species more vulnerable to brain disease, neurological disorders and autism. At the same time, the gut microbiome has gained attention as one of the major contributors to the pathogenesis of multi-system inflammatory disorders. We will explore some research that elucidates the different ways our microbiome is responsible for inflammatory conditions, our immune system development and microglial maturity and function. We will also discuss the most recent advancements in our understanding of the gut microbiome's clinical significance in regulating blood-brain barrier (BBB) integrity. Finally understanding the complex signaling interactions between gut microbes, metabolites, neural development, immune mediators, and neurobiological functionality. In conclusion, we will explore what we can still do to reverse this trend and what conditions we can only manage to maximize potential.

Objectives

• The importace of preserving the healthy balance in our inner ecosystem, the microbiome
• How the transgenerational loss of crucial microbes over generations is making us more vulnerable to neurological diseases
• To understand the pathway from systemic inflammation, and immune system dysregulation to blood-brain-barrier disruption, ultimately resulting in autism and other neurological conditions.

Presenter: Greer McGuinness MS, RD, CDN, CLT, Dt.Spt.

Title of Talk: How toxins are impacting the pediatric brain and functional medicine approaches to healing and detoxing

Abstract:

Chronic health conditions in children, including Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD), are on the rise, with current rates reaching alarming levels. This increase in developmental disorders may be attributed to a combination of metabolic, genetic, and environmental factors. The U.S. has seen a dramatic rise in toxin production and exposure, particularly neurotoxins, which can be classified into persistent and non-persistent categories. These toxins pose significant risks, especially to developing children. Early brain development is critical, with the first 1,000 days representing a window of heightened vulnerability to environmental influences. During these sensitive and critical periods, toxin exposure can disrupt key processes in brain development. By age five, 90% of the brain has already developed, making early exposure to toxins a major concern for long-term cognitive health. Currently, children are being affected by a wide range of toxins, including heavy metals, mycotoxins, and pesticides. These toxins wreak havoc on the brain, gut, liver, and other vital systems. To combat this, a holistic approach to detoxification is necessary. Laboratory testing plays an essential role in identifying and addressing toxin exposure. Stool tests provide insight into gastrointestinal function, while micronutrient testing helps correct nutrient deficiencies critical for liver detoxification. Toxin testing can identify exposures to heavy metals, mold, and environmental pollutants, such as PFAS. Diet and supplementation are crucial components of a child-focused detox strategy. My Rebalance Method incorporates foods that naturally support detoxification and safe, effective supplements designed for children. Together, these interventions aim to reduce the toxic burden on children and support optimal health outcomes.

Objectives

Toxins

• Toxins that are currently impacting our kids (Heavy Metals, Mycotoxins, Pesticides)
• How toxins are damaging the bodies (Brain, Gut, Liver etc.)
• My 4-pillar approach to detoxing (Clean Air, Food, Products, Water)

Laboratory testing

• Stool Testing (Assessing GI function)
• Micronutrients (correcting nutrient deficiencies that impact the liver function for detox)
• Toxin Testing (What toxins can we test for Heavy Metals, Mold, Environmental toxins, PFAS)

Food & Supplements

• How to start the detox approach with kids
• My Rebalance Method
• Foods that can aid in detox
• Supplements that are safe and effective for detoxing kids

Presenter: Pejman Katiraei, DO

Title of Talk: Disruptions in Neural Circuitry from Microglial Activation

Abstract:

The microglia are the primary immune sentinels of the nervous system. They shape neuronal plasticity, connectivity, and synaptic function and wiring. When overactivated, microglia disrupt these and other neural critical pathways, damage the neurons and their myelin sheath, and exacerbate neurotoxicity through elevations of compounds like quinolinic acid.

Various toxins and physiological stressors, including COVID and RSV, can disrupt the gut barrier and allow the release of bacterial endotoxins into circulation. Bacterial endotoxins are one of the most powerful activators of the microglia, and when the gut is sufficiently disrupted, the resultant endotoxemia can become a permanent state inducing life-long neuronal damage and toxicity.

Children with autism have endotoxemia, microglial activation, and disrupted neural circuits. This talk will discuss how these physiological events unfold and offer simple treatment options for providers to help address and even reverse the consequences of these physiological events.

Objectives

• This presentation will help audience members understand the various factors that can create a chronic disruption of the gastrointestinal barrier.
• This presentation will explore how this disruption induces a chronic state of endotoxemia, and how this endogenous toxicity is sufficient to cause neuronal dysfunction resulting in the presentation of autism.
• The presentation will explore possible treatment options to address the endotoxemia and downstream microglial activation.

Presenter: Dr. Elizabeth Torres, PhD

Presenter: Elizabeth Bonker

Title of Talk: Regulation 4 ALL: Heart Rate Variability Project Launched

Abstract:

One year after Elizabeth Bonker presented her 2-year experiment to get out of fight-or-flight state, she has partnered with the Rutgers University Sensory Motor Integration Laboratory (SMIL) under Dr. Elizabeth B Torres, to launch Regulation 4 ALL. Regulation 4 ALL is a new program that aims at helping detect dysregulation in the autonomic biorhythms and identify activities and contexts that help stabilize them. The new model leverages participant-centered research at SMIL, whereby families are active contributors to the science. The scalable personalized program is based on patented algorithms that enable direct measurements and tracking of shifts in biorhythmic stochastic signatures at a micro-level of variability.

We present the outcomes from our first collaborative pilot study. This study tracked for 3 months the heart rate variability (HRV) and the facial micro-movements (FMS) of 50 nonspeakers, providing proof of concept for the development and validation of an app that can non-invasively track the biorhythmic activities of the person. Using personalized methods based on direct measurements of the individual, rather than on grand averages from ML-inferred population estimates, or synthetically generated AI data, the app will be a first of its kind.

Dr. Torres has created a course that explains to the public the basic foundations of the research methods, the protocols and their use, to help disseminate the findings from this work and educate the public, including families, first responders, educators and clinicians on the Regulation 4 ALL program.

Objectives

• Understand the scientific foundations of micro movements in biorhythmic activities registered from the nervous systems and personalized biometrics tailored to autism and neurodiverse populations
• Describe and explain the physiological meaning of the parameter ranges signaling dysregulation
• Learn how to use Regulation 4 ALL with your patients to empower their families to regulate the person and alleviate their stress and anxiety

Presenter: Dr. Richard Deth, PhD

Title of Talk: Redox regulation of the NLRP3 inflammasome and its implications for autism

Abstract:

Neuroinflammation is thought to play a significant role in autism and the NLRP3 inflammasome, which is a major source of cytokine production, has been shown to be activated in autistic subjects. Notably, oxidative stress promotes NLRP3 activity and oxidative stress is a common feature of autism. To investigate the basis of redox regulation of NLRP3 we measured changes in the levels of antioxidant and methylation pathway metabolites during its activation by lipopolysaccharide (LPS) in THP-1 cell-derived macrophages. Time-course studies revealed an initial dramatic decrease in thiol metabolites upon LPS exposure that accompanied production of IL-1beta, followed by a restoration of levels at later timepoints (e.g. 24 hrs). The initial increase in IL-1 beta production was accelerated by ATP, which activates the P2X7 receptor, and this effect of ATP was blocked by treatment with the P2X7 inhibitor suramin. These results are consistent with previous work reporting low GSH levels in response to LPS, suggesting that restricted antioxidant resources promote NLRP3 activity. Indeed, the BTBR mouse model of autism exhibits NLRP3 activation in conjunction with markedly how brain levels of cysteine. An examination of cysteine residues in NLRP3 and P2X7 revealed multiple consecutive pairs, which may confer unique redox sensitivity. Moreover, since NLRP3 activation is a crucial response to vaccination, our findings also suggest that individuals with impaired antioxidant resources and oxidative stress are at higher risk for excessive inflammation and untoward effects of vaccination.

Objectives

• What is the role of the NLRP3 inflammasome in inflammation?
• How does oxidative stress affect NLRP3 activity?
• What are the implications of impaired antioxidant capacity in autism for the risk of neuroinflammation?

Presenter: Gabriela Guimaraes MD MS

Title of Talk: beyond the light: the role of photobiomodulation in neurodevelopmental disorders

Abstract:

Brain photobiomodulation (PBM) therapy using red light is an innovative treatment for a wide range of neurological and psychological conditions and has been gaining increasing interest. Low-level light therapy (LLLT) is able to modulate mitochondrial activity, stimulating through the enzyme cytochrome C oxidase, the increase in cellular energy production, and consequently the synthesis of ATP. In addition, the therapy increases neuronal metabolic capacity, including cerebral blood flow, and stimulates anti-inflammatory and antioxidant responses. In addition, the absorption of light by ion channels results in the release of Ca 2+ and leads to the activation of transcription factors and gene expression. PBM has shown a therapeutic role in neurodevelopmental disorders such as ASD, being a therapy capable of safely reducing symptoms, improving language and modulating brain electrophysiology.

Objectives

• What is photobiomodulation
• Effects of photobiomodulation
• Indications of treatment by photobiomodulation including neurodevelopmental disorders

Presenter: Julie Matthews, MS

Title of Talk: Mechanisms of Action of Therapeutic Diets in Neurodevelopmental Disorders

Abstract:

This presentation will explore the scientific basis of how specific therapeutic diets can address underlying factors such as gut microbiome imbalances, GI dysfunction, oxidative stress, mitochondrial dysfunction, nutrient deficiencies and impaired biochemical pathways, poor detoxification, and abnormal metabolism affecting children with neurodevelopmental disorders. The talk will highlight the latest scientific evidence supporting the role of various therapeutic diets—such as ketogenic, specific carbohydrate, low oxalate, low salicylate, low histamine, GFCF, and low FODMAP diets—in improving symptoms and overall outcomes in conditions like autism spectrum disorder (ASD), ADHD, PANDAS, and other neurological conditions. Emphasis will be placed on the diet's potential to modulate these underlying pathways, offering clinicians practical insights into dietary strategies tailored to individual patients.

This presentation can be modified to focus on certain diets or mechanisms as desired.

Objectives

• Understand the Biological Mechanisms: Identify the key underlying biological factors in neurodevelopmental disorders—such as gut microbiome imbalances, GI dysfunction, oxidative stress, mitochondrial dysfunction, nutrient deficiencies and impaired biochemical pathways, poor detoxification, and abnormal metabolism—and how therapeutic diets modulate these mechanisms to support neurological function.
• Explore Specific Therapeutic Diets: Examine the mechanisms and benefits of various therapeutic diets, including ketogenic, specific carbohydrate, low oxalate, low salicylate, low histamine, GFCF, and low FODMAP diets, and their role in managing symptoms of neurodevelopmental disorders.
• Translate Science into Clinical Practice: Learn how to apply the latest scientific evidence on therapeutic diets to clinical practice by tailoring dietary interventions to individual patients with neurodevelopmental disorders, optimizing treatment strategies based on underlying biological imbalances.

Presenter: Thomas J. Lewis, Ph.D.

Title of Talk: 8Rs of Gut Health Rehabilitation

Abstract:

Gut health rehabilitation is a multi-step process. The University of Wisconsin developed a 4"R" program for leaky gut. Here I describe a more comprehensive 8"R" program, the components of which are: Remove, Reduce, Replace, Re-inoculate, Ruminate, Rate, Repair, and Reinvigorate. One novelty to be discussed is how to rotate a wide variety of probiotics, the foundations of which is organism strain diversity. Fecal transplants are now thought to contain at least 1,000 unique organisms, and some research indicates the strain varieties could be as high as 10,000 unique organisms. Most probiotics have ten or fewer unique organisms. A second novelty is a case of a young girl who performed multiple enemas that cured a long-standing gut problem. Finally, I will also discuss an inexpensive blood-based biomarker that is a barometer for microbiome integrity and gut health.

Objectives

• Understand the multi-step process to better gut function.
• Know how to implement alternative microbiome enhancement interventions
• Know how to read blood work to determine if and to what extent, gut health is impacting whole body health.

Presenter: Lisa Wada, ND

Title of Talk: Navigating the Unique Challenges of Autism and Puberty

Abstract:

During puberty, there is a significant increase in sex hormones, particularly testosterone in boys and estrogen in girls, which greatly affects brain development and functioning. For individuals with autism, who may already have distinct differences in brain structure, these hormonal changes can lead to several notable effects:

• Amplification of Autistic Traits: Hormonal changes may intensify existing traits, leading to increased repetitive behaviors and heightened sensitivity to sensory input.
• Emotional Regulation Difficulties: The surge in hormones can disrupt emotional balance, making it harder for autistic individuals to manage their emotions, which may result in more frequent meltdowns or shutdowns.
• Changes in Social Behavior: These hormonal shifts can influence social motivation and awareness, potentially increasing social anxiety or, alternatively, the desire for social interactions, along with the emergence of romantic feelings and challenges with boundaries.
• Effects on Executive Functioning: During this developmental stage, autistic individuals commonly face increased challenges in planning, organizing, and managing daily tasks.
• Recognizing these effects is crucial for offering appropriate support and strategies to help navigate the challenges of puberty and the unique ways autistic individuals can experience this phase of life. Supporting hormone balance with Functional Medicine can help mitigate some of the negative symptoms that can accompany puberty.

Objectives

• Understand Hormonal Influences: Explain how the surge in sex hormones during puberty affects brain development and functioning, particularly in individuals with autism.
• Identify Behavioral Changes: Describe the specific ways in which hormonal changes can intensify autistic traits, impact emotional regulation, and alter social behaviors during puberty.
• Natural Ways to Support Needs: Discuss targeted support and strategies for autistic individuals navigating the challenges of puberty with functional medicine.

Presenter: Nancy H. O'Hara, MD, MPH, FAAP, FMAPS

Title of Talk: Alice in Wonderland Syndrome: Follow Me Down the Rabbit Hole to the Diagnosis & Treatment of These Children

Abstract:

Have you ever seen a child with Alice in Wonderland Syndrome (AIWS)? AIWS is a neurological disorder that affects how you perceive your body and the world around you, seeing things as either smaller or larger than they are and affecting how you perceive time and motion.

AIWS is felt to be rare but increasing over the past few years. Reported cases indicate that the most common cause is migraines, but also linked to epilepsy, central nervous system lesions, head trauma and bacterial or viral infections, including Epstein-Barr infection.

Dr. O’Hara will present the evidence-based research of important causes of AIWS including the above as well as COVID and Babesiosis. She will discuss the assessment, diagnosis and treatment of these children through an extensive review of the research as well as clinical cases.

Objectives

• The participant will understand the symptoms and appropriate testing and assessment of children with AIWS.
• The participant will delineate the differential diagnosis of AIWS.
• The participant will differentiate the 3-pronged approach of providing symptom relief, discovering and treating the underlying trigger(s) and supporting immunomodulation.

Presenter: William Kracht, DO

Title of Talk: Childhood Infectious Diseases: Integrative Medical Management

Abstract:

There has been recent resurgence of childhood infectious diseases, such as measles and pertussis. Although much attention is given to immunizations for prevention of childhood infections, little consideration has been given to treatment, especially early treatment. Treatment options are important to manage vaccine breakthrough infections, and for children in whom immunizations are medically contraindicated or voluntarily decline immunizations due to philosophical or religious reasons. This presentation will review the integrative medical management of viral and bacterial childhood infectious diseases.

Objectives

• To understand the pathophysiology of common childhood viral and bacterial infectious diseases.
• To understand the importance of early treatment.
• To review early treatment protocols for common childhood viral and bacterial infectious diseases.

Presenter: Scott Antoine, DO, FACEP, ABOIM

Title of Talk: Practical Applications of Hypnosis and Neurolinguistic Programming to Treat Severe OCD and Anxiety in Children

Abstract:

Studies have shown that mental health disorders in children and adolescents are increasing at an alarming rate. Worldwide, it is estimated that 8.8% of children and adolescents have been diagnosed with some form of mental illness. This number has significantly increased over the last 30 years. Neurologic looped behaviors (such as OCD) are a significant source of suffering for patients and families alike. About 1-4% of children are thought to have OCD and the World Health Organization has identified OCD as one of the top ten most disabling disorders known to man. Anxiety disorders in children are also increasing, even more so since the COVID-19 pandemic. Severe anxiety is associated with chronic activation of the fight-or-flight response.

Pediatric Autoimmune Neuropsychiatric Disorders Associated with Strep infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS) are forms of autoimmune encephalitis. In these conditions, children and young adults develop sudden, severe neuropsychiatric symptoms following infections. Severe OCD and anxiety are part of the case definition of PANS and PANDAS. The disabling nature of the OCD and anxiety symptoms in these children presents a particular treatment challenge for practitioners, patients, and families.

While cognitive behavioral therapies (CBT) like Exposure Response Prevention (ERP) are more effective than medications at helping break neurologic looped behaviors like OCD and reduce anxiety in affected children, these therapies are usually only offered once per week and can take a considerable amount of time to be effective.

Techniques taken from the fields of hypnosis and neurolinguistic programming (NLP) provide powerful, effective interventions that parents and practitioners can use to break the cycle of OCD and anxiety and help usher children with OCD and anxiety into an enjoyable life free of these burdens in a shorter period of time. This lecture will introduce participants to these techniques and provide practical guidance so that practitioners can leave this lecture with the confidence that they can use them in their patient population. Although the discussion will use examples of techniques used in children with PANS and PANDAS, these techniques are useful for OCD and anxiety in children regardless of the etiology.

Objectives

As a result of this presentation, learners will discover:

• Common presentations of OCD and anxiety in children with PANS and PANDAS
• The biochemical basis for OCD in children with PANS and PANDAS
• The role of behavioral therapies in OCD and anxiety
• The role of the subconscious mind in behavioral regulation and beliefs
• Practical techniques from the disciplines of hypnosis and NLP that they can use immediately to serve pediatric patients with OCD and/or anxiety regardless of the etiology

Presenter: Dr. Michael Milobsky, MD, FAAP

Title of Talk: Integrative Medicine Approaches to Adolescent Mental Health: A Three-Year Review

Abstract:

Adolescent mental health is a growing public health crisis in the United States, with alarming increases in depression, anxiety, suicidality, ADHD, and substance abuse. Colorado ranks among the worst states nationally in these areas, prompting Children’s Hospital Colorado to declare a state of emergency for youth mental health in 2021. Suicide has tragically become the leading cause of death for Colorado youth aged 10-18, and reports of depression and anxiety are at an all-time high. In response, our large pediatric primary care practice in Castle Rock, CO, opened The Way Center in January 2021—a clinic dedicated to addressing teen mental health. Over the last three years, we have developed an integrative medicine approach to assessing and treating adolescent mental health issues, with a particular focus on ADHD, which remains the most common concern among our patients and their families. Despite receiving little to no formal training in integrative medicine during my medical education and residency, I embarked on a journey three years ago to fill this gap. This effort was driven by patient demand for alternative and adjunctive therapies to traditional ADHD treatments. My education has centered around resources like the Andrew Weil Foundation’s “Integrative Pediatrics” (Colbert and Ulness) and “ADHD Without Drugs” by Dr. Salzman from UCSF’s Osher Center for Integrative Health. These teachings have not only refined my approach to ADHD but have also reshaped my overall practice in pediatric medicine. In this session, I will present our clinic’s three-year experience in managing adolescent mental health, highlighting how integrative medicine has played a pivotal role in improving outcomes. The presentation will delve into practical strategies for incorporating integrative methods in pediatric mental health care, addressing parental concerns, and providing comprehensive, patient-centered treatment plans. Key Findings: We have found that general parental acceptance and engagement in the process has been significant. General feed back from families indicates a heightened sense of ownership and empowerment both from parents and children as well as increases optimism and sense of control around the diagnosis. We feel this has improved compliance and continued involvement with our program. Our greatest challenge was upgrading our knowledge base on these topics to feel comfortable and competent on advising and implementing an Integrative medicine approach in practice.

Our future goals for the clinic are to add a full “Wellness” program to provide more resources for our patients to learn self-regulating techniques through such modalities as Yoga, Breathwork, Aerobic fitness and mindfulness training . My hope is that this presentation will inspire other primary care pediatricians to explore integrative medicine approaches in their practices and offer new pathways to improved mental health outcomes for adolescents Presenter: Dr. Michael Milobsky, MD, FAAP

Objectives

• Overcoming knowledge deficit in Integrative medicine for pediatricians
• Implementing and Integrative approach to adolescent mental health
• Key components of Integrative medicine approach to adolescent mental health using ADHD as a model

Presenter: James Neuenschwander, M.D., FMAPS

Title of Talk: Biochemical Basis of the Integrative Approach

Abstract:

This whirlwind presentation will cover the biochemistry that underlies the integrative/biomedical approach. We will cover the methylation pathways and how they connect to sulfation and detoxification. We also look at the details fot he gut-brain- immune triad and the impact of gut health on the entirety of heath. We will dive into mitochondrial, its impact on cell signaling, and the importance of the ell danger response. We will look at the chemistry of membrane lipids and foundations of the type and balance of the fats that make up our membranes. Finally, we will look at the impact of toxins on the function of our kids’ physiology. For those of you with a firm grasp of biochemistry, this is a great review, and you will learn something new. For those of you that are new to the integrative approach, this will give you an idea of everything you will learn in our fellowship. By the time we are done, you will have a firm grasp of the biochemical basis of the biomedical approach.

Presenter: Dr. Taylor Bean, ND, FMAPS

Title of Talk: The Power of Vitamin A

Abstract:

One of the most underestimated yet powerful vitamins we have among us is vitamin A. This important vitamin was first discovered simultaneously in 1913 by two separate research pairs working at the University of Wisconsin and Yale University. Today, we have come to understand much more behind the power of Vitamin A – from epithelial tissue support, growth and bone development, night vision, immune function, warding off severe cases of measles to anti-cancer support.

Health agencies have become relucent to suggest vitamin A due to its potential toxicity; however, with understanding what toxicity levels are, we can prescribe this vitamin safely. We will discuss maintenance dosages for our pediatric population along how we can support them during or after infections. Where do we get vitamin A in our food? We will discuss both animal and plant sources and what the differences are.

Objectives

• How Vitamin A plays a critical role in immune function
• Why it is important for endothelial tissue
• Dosing to toxicity in pediatrics for both maintenance and treatment

Presenter: Dr. Julie Logan D.C.

Title of Talk: Balancing the Autonomics and Healing the Limbic System for Optimal Outcomes

Abstract:

This lecture will present the research demonstrating how spinal manipulation and cranial manipulation therapies can correct sympathetic dominance, dysautonomias such as POTS, and measurably change both inflammatory markers and neuropeptides for the better.

Then we will also explore novel and emerging therapeutics for healing the disordered limbic system: Recovering from illness is more than just stopping the symptoms of the disease. The experience of suffering itself creates injury to the limbic system and to our consciousness. It is becoming apparent that limbic dysfunction can remain even after thorough and successful treatment of disease, and may play a very important role in the recovery process from chronic inflammatory illness

This subject will pull from the works of holistic psychiatrist Dr. Mary Ackerly, and experts such as Dr. Neil Nathan to discuss healing modalities, including BrainTap, meditation programs, FSM, and others to achieve the correction of the ‘Danger Response” experienced by so many of our highly sensitized patients.

Objectives

• Attendees will understand how spinal and cranial manipulations directly improve the function of both the autonomic nervous system globally and immune markers and neuropeptides specifically
• Attendees will gain familiarity with the concepts of limbic system dysfunction as both result of and cause of chronic disease
• Attendees will learn about therapeutic interventions that are being studied for their ability to normalize limbic and autonomic function

Presenter: Svetlana Masgutova, Ph.D.

Title of Talk: Primitive and Primary Reflexes: How Progression of Reflex Maturation Optimizes Neurodevelopment in Babies and Children

Abstract:

Reflexes support various functions essential to human survival and development. Proper and healthy primary reflex function provides a foundations for nervous system and immune system health, stress resilience, neuroplasticity, emotional-behavioral regulation, motor learning, and cognitive development. Primary sensory-motor reflex patterns follow a process of Emerge => Develop => Mature => Integrate, corresponding to extrapyramidal system and pyramidal system maturation. However, primary reflexes often do not integrate within the proper timeline or are reactivated due to a stressful or traumatic event.

The MNRI® / Masgutova Method® of Reflex Integration is considered a root-cause intervention that recognizes underlying challenges, isolates the impacted primary sensory-motor reflexes, and targets the associated sensory-motor dysfunction. MNRI® restorative techniques reduce or eliminate the negative compensations developed due to unintegrated reflexes that have resulted in developmental challenges and delays, thereby improving functional outcomes and overall academic enhancement, health and well-being. When MNRI® treatment precedes or is used as a complementary intervention with traditional therapies such as occupational therapy, physical therapy, and speech therapy, individuals demonstrate more efficient and sustainable progress in reaching developmental milestones and nervous system regulation. Decades of practical application and clinical research have demonstrated that MNRI® exercises and techniques can optimize pediatric neurodevelopmental outcomes. Brain mapping research also will be presented to objectively emphasize results.

Objectives

• Understand the significance of the maturation and integration of primary reflexes.
• Learn about developmental implications if a reflex does not mature properly or is reactivated due to a stressful or traumatic event.
• Understand more about why MNRI reflex integration is an effective intervention that can help optimize developmental outcomes in children with challenges.

Presenter: Brian Hooker, PhD

Title of Talk: The Neuroimmunology of Autsim

Abstract:

Alterations and maladaptation of the immune system remain some of the most controversial concepts in autism spectrum disorder (ASD). Nonetheless, intensifying evidence confirms that much of what ASD involves is related not to fixed “autistic states of being” but rather to the consequences of environmental insult and complex psychological and physiological processes along a neuro-immune-microbiota-axis. Beginning with an epidemiological and etiological underpinning, followed by biochemical and psychiatric standpoints, we elaborate on the current role of the immune system in the pathophysiology of ASD. Finally, taking a neuroimmunological perspective, we highlight the need for a multi-scale, holistic, and “middle-out” approach to understanding and developing future therapeutic modalities to address the core symptoms of ASD that go beyond the current reductionist and “magic-bullet” medical paradigm.

Objectives

• To understand the gut-brain-axis from a neuroimmunological perspective.
• To understand the implications of immune dysregulation on neurological structure and function.
• To explore treatment modalities in light of these new developments.

Presenter: Kathleen Johnson, DNP, FNP, PMHNP, PMHS, FMAPS

Title of Talk: Evaluation and Diagnosis of Autism: From Soup to Nuts in Clinical Practice.

Abstract:

Autism Spectrum Disorder has been increasing in prevalence (1:36; CDC 2024). However, the wait time for autism assessment ranges from over 4 months (61%) to over one year

Many children and their families have to wait an average of three years for an autism assessment after concerns for developmental delays are identified; this delay is largely due to the lack of available specialists and the absence of a ""standard of care"" for evaluation (Bridgemohan et al., 2018; Ramsey, 2023). A study of 111 centers in 28 states showed that barriers for children accessing timely autism evaluations are workforce shortages (69%), large volumes of referrals (61%), the time needed to write reports and documents (54%), time to conduct evaluations (37%) and poor reimbursement (30%; Kraft et al, 2024). Of the clinics responding to the Kraft et al. (2024) study, patients wait over 4 months (nearly two-thirds) to a year or more (21%), 65% of these clinics take commercial insurance and 44% do not take any Medicaid. This varies greatly, as in Washington State, the average wait time was 12 months or longer, particularly in rural areas (WSC, 2024). Additionally, behavioral health concerns in children and youth with autism need to be identified promptly to allow for early interventions (Cantor et al., 2021; Kerns et al., 2021)

Applying a streamlined diagnostic evaluation and documentation flow in clinical practice can support healthcare providers to increase available autism diagnostic and treatment services with children, teens, and young adult patients. Timely diagnoses may lead to earlier interventions and services, and therefore improve long-term outcomes and quality of life for patients and families, as well as increase provider satisfaction in practice.

This presentation will give a ""from soup to nuts"" overview of the neuro-developmental-behavioral evaluation. The use of developmental interviews, validated screening forms and diagnostic tools for autism and co-occurring behavioral health challenges, efficient documentation/report writing, and appropriate CPT billing codes and time notes for reimbursement will be reviewed. Participants will have resources to apply this in clinical practice, according to their scope of practice and State regulations for practice, to decrease disparity and increase access to early intervention and care.

Objectives

Learning Objectives:

• Participants will have an understanding of the need and benefits for expanding diagnostic services in clinical practice (according to state guidelines).
• Participants will gain familiarity with screening and diagnostic tools to assess autism spectrum disorder and co-occurring ADHD, anxiety, depression, and suicidal ideation/risk.
• Participants will gain resources for recording screening tools, report writing, school letter language for accommodations, and billing codes/time notes.

ADDITIONAL OUTLINE DRAFT

Objective 1:

• -Neurodevelopmental-behavioral health disorders of childhood and prevalence
• -Need for supports and accommodations often relies on gaining appropriate diagnoses, but severe challenge to getting formal diagnoses (with long wait).
• -Need for “throwing a wide net” and performing comprehensive neuro-developmental—behavioral assessment with appropriate diagnoses.
• -Awareness of co-occurring behavioral health (psychiatric) disorders with developmental disorders (autism, ADHD, other delays of childhood) helps bring opportunity for interventions (ie: therapy, integrative, pharmacologic awareness, not deep dive into treatments) to help decrease escalations of challenging behaviors, social isolation, suicide, and increases opportunities for participation with peers and achieving milestones (rationale for throwing a wide net in the beginning with neuro-developmental-behavioral evaluation)

Objective 2:

• -DSM 5 criteria for autism, ADHD, anxiety, depression review
• -Developmental-Behavioral interview example (template, guideline, streamlined with DSM 5)
• -Screening Forms for Autism Assessment: (some examples, may add more)
• -Cambridge/AQ (how to order and score)
• -RAADS-R
• -CAST
• -SRS-2 (how to order and score)
• -Vineland-3 (how to order and score)
• -ABAS-3
• -Tele-ASD-Peds (from Vanderbilt Triad)
• -STAT: Familiarize and resources for training/kit
• -ADOS-2: Familiarize and resources for training/kit
• -ADHD and Mood forms (several for each age group toddler through adults)
• -SCARED, CBCL, ECSA, PSQ17
• -Preschool ADHD, Vanderbilt ADHD, SNAP-IV, Adult ADHD, and clinical interview (w. autism is EB)
• -ATEC: Overview, resource, how to score and use in practice

Objective 3:

• -Report example template, dot phrases for documentation of screening/diagnostic forms
• -Diagnosis letter for school accommodations (with language examples)
• -Time Note & Billing Codes Resources (Getting reimbursed for services/insurance coding tips/time note)

Presenter: Isabelle Renard-Fontaine, MSPT, NICU

Title of Talk: Effect of Reflex Neuromodulation on an Infant with Severe Amniotic Band Syndrome: A Case Report on the Extraordinary Functional Outcomes of Early Intervention using MNRI Techniques for Physical Therapy.

Abstract:

This evidence-based case study supported by research, peer-reviewed publication (2017), as well as by abundant exceptional videos and pictures, aims to demonstrate significant progressive results of the practical application of the MNRI primary reflex integration intervention throughout early infancy stages (2.5 mo-36 months) for a child with severe amniotic band syndrome.

The severity of the constricting band blocked all circulation. It resulted in severely damaged vascular, muscular, and neurological tissue development with post-birth absence of any sensory/motor control in the right upper arm from the mid-arm down to the fingers. This infant was at a high risk for an amputation of her limb and was identified with poor rehabilitation potential based on traditional therapy intervention. This case necessitated a unique, non-traditional approach to solving severe musculoskeletal/biomechanics pathology and congenital trauma. The chosen intervention for this infant has been based on several reflex neuromodulation concepts:

• A reflex is defined as being automatic and encoded/inherent.
• A reflex is characterized by precise biomechanics and 'known' neuro sensorimotor circuit functions.
• A reflex has its own developmental dynamic.

This concept has been supported by Sechenov's and Ch. Sherrington/s axiomatic statement: «A Reflex is the Unit of the Brain» (Sechenov, 1861/1975).

The MNRI® Method, a non-invasive manual Reflex Neuromodulation procedure created by Dr. Svetlana Masgutova, Ph.D., a world-renowned expert on reflex integration, offered unique and progressive results. This case study shows improvement in the infant's specific reflexes and a remarkable recovery from her intrauterine injury; some manual abilities and cognitive function were restored. The chosen intervention has proven to be most productive for the facilitation of the Neurodevelopment of the child in the described case study (see the publication in the Journal of Neurorehabilitation: www.researchgate.net/publication/315175571_Effect_of_Reflex_Neuromodulation_on_an_Infant_with_Severe_Amniotic_Band_Syndrome_A_Case_Report_on_the_Use_of_MNRI_Techniques_for_Physical_Therapy

This presentation includes unique videos of the direct brain response in the absence of the muscles functioning to create movement and additional updates on the child's recovery since the publication.

Objectives

• Understand the concept of the use of ready patterns of the brain-primary inherent reflexes- as a key method and an important cornerstone for professionals such as PT’s, OT’s and Speech therapists.
• Present/Educate medical professionals and parents about the Masgutova Reflex Neuromodulation based method as an effective approach for supporting and/or restoring dysfunction/pathological neuroDevelopment through a real life-concrete case.
• Understand how the use of infant reflexes, as unit of the brain (concepts by Sechenov), leads to increased potential for neurological trauma recovery and restoration of severe pathological sensory-motor dysfunction versus a traditional therapy approach.

Presenter: Elizabeth Mumper, MD

Title of Talk: Neurologic sequelae of COVID

Abstract:

Both COVID the illness and COVID the injection have been associated with significant neurologic sequelae. Dr. Mumper will review various neurologic manifestations of long COVID and vaccine injury and potential interventions to restore better neurologic function.

Objectives

• To recognize the variety of neurologic disorders that may present in post-COVID times.
• To learn the pathophysiology of neurologic abnormalities after COVID infection or injection.
• To review potential therapeutic interventions to help these patients.

Presenter: Krishna Doniparthi, MD

Title of Talk: Phospholipid architecture related to seizures and epilepsy

Abstract:

Phospholipids and its related substrates, like cardiolipin, sphingolipids, lipid droplets and others, play a role in the structure of a cell and having abnormal or missing lipid substrates leads to an abnormally functioning neurons that results in either seizure disorder or epilepsy.

Objectives

Learn which lipid substrates help with neuronal function, Learn what deficiencies in lipids leads to seizure disorder or epilepsy, Know which lipid substrates in clinical setting can help with seizure disorder and epilepsy

Presenter: Richard G. Boles, M.D.

Title of Talk: Changing the Course of Autism Through Genetics Guidance

Abstract:

Whole genome sequencing (WGS) trios (patient + parents) raw data was reanalyzed in 50 patients with autism seen by Dr. Boles. Primary Diagnostic Variants (PDVs; comprising the bulk of genetic causation) were provided in 34/50 (68%) cases, including 25 (50%) with de novo variants (new mutations, absent from parents). In most cases, the PDV was not listed on the laboratory report, with new disorders found in 14 cases. Treatment recommendations based on DNA analyses were provided in 33 (66%) patients, frequently with clinical improvement.

A follow-up study in 100 autism patients of Dr. Frye has completed data collection and is now in analysis. This second study confirmed the previous findings in that over half (53%) of the patients have a de novo PDV in a gene related to autism.

Our results demonstrate high yield of trio-WGS data reanalysis in autism. The pathways represented by the identified variants (e.g., mitochondrial energy metabolism, cation transport, neurotransmission) can target individualized treatment, and inform on additional treatment options in patients not sequenced. Furthermore, our studies suggest that a de novo variant is the most-common genetic factor in autism. These new mutations likely occur due to environmental factors (e.g., chemical damage in sperm production). Our findings can explain the mechanism as to how many common MAPS therapies are successful in a minority of patients, as well as the dramatically-rising prevalence of autism.

Objectives

• To learn how whole genome sequencing (WGS) with comprehensive sequence reanalysis can elucidate individualized genetic factors predisposing towards disease in patients with autism.
• To discover that WGS has identified a small number of key pathways, many of which are treatable. These pathways predict the efficacy of many of the common MAPS-based therapies used.
• To understand how knowledge of these pathways can inform on treatment options in individual patients, including in those without the benefit of WGS.

Presenter: Monika Buerger, BA, DC

Title of Talk: The Role of Neuroglia in Pediatric Mental Health

Abstract:

This lecture will focus on the critical role of neuroglia (primarily microglia) in regulating neurotransmission and the excitatory-inhibitory balance in the CNS. It will take the attendees through a systematic process, from gene-environment interactions in utero and postnatally to immune modulation and synaptic pruning and the role of microglia. This will lead to a brief discussion on the role of microglia in sensory-motor processing, a common co-morbidity in autism and other developmental disorders associated with stereotypic and repetitive behaviors. Research using specific nutritional agents to help modulate microglia activation and the findings of reduced autism-like behaviors will be presented. The lecture will conclude with suggested protocols to help modulate microglia activity for optimal CNS function.

Objectives

• For attendees to understand the role of neuroglia in immune modulation and neuronal pruning for proper neurodevelopment
• For attendees to understand how neuroglia regulate glutamate-GABA balance and how this will affect behavior in the pediatric population (primarily in autism and schizophrenia)
• For attendees to gain confidence on how to support neuroglia activation/modulation

Presenter: Bob Miller, BCTN

Title of Talk: The Findings of the PEARL Autism Study

Abstract:

Precise Health Solutions, LLC, aligned with the Department of Nutrition and Food Science at Purdue University, conducted a 12-week Pilot Program in the Fall of 2024 to evaluate the effect of family-based nutrition counseling and education, culinary skills, and a personalized meal and lifestyle plan for adolescents and young adults with autism (9-35 year-olds). Local Farmers contributed organic food. Participants were provided organic products from Orgain Nestlé Health Science and instructed to prepare smoothies for snacks or meal accompaniments.

The 12-week intervention included personalized nutrition and lifestyle plans following USDA My Plate guidelines, including selecting organic, chemical-free foods, six nutrition education sessions, and a custom multivitamin-mineral supplement formulated for this study.

Methods:

Laboratory-based measures collected at baseline and week 12 include a food sensitivity test correlated to cytokines (KBMO), blood and urine measurement of vitamins, minerals, organic acids, amino acids, and fatty acids (Mosaic Diagnostics), and a comprehensive metabolic panel including CMP. CBC, lipid panel, thyroid, and cytokine panels (table 1) Insulin, HbA1c, GGT, CRP, a cytokine panel, IgG, IgA, IgE, Histamine, ANA (and others) were also measured in each participant. (Health Lab Northwestern Medical Lab)

Analyses also included unprovoked heavy metals, mycotoxins, pesticides, and other chemicals. An advanced diagnostic GI Stool Test for analysis of the composition and functionality of the gut microbiome, including a Gastrointestinal Symptom Rating Scale DNA sequencing technology. 24-hour food recalls were routinely evaluated, and adherence was monitored weekly. Access to the clinical team virtually and via private social media connections kept the communication lines open throughout the program. Iowa State University will conduct microRNAs (miRNAs), small non-coding RNAs that regulate gene expression. (McNeill Lab)

Each participant also tested their functional genomics and was analyzed for their genetic predisposition for higher histamine, glutamate, Glutathione, detox pathways, methylation, Iron dysregulation, inflammasomes, IL-6, IL-18, IL-1β, and potential genetic weakness in autophagy and antioxidant production. We analyzed the correlations between the genetic findings and lab results.

In this talk, we will report on any unique findings that may be useful for practitioners in their treatment of ASD.

Objectives

• Discover if there are any unique food allergies, mycotoxins and environmental toxins in the pilot study.
• Discover if there are any unique abnormalities in labs in the pilot study
• Discover how labs and behaviors changed when on an organic diet and multi-vitamin/mineral were implemented.
• Discover if there was any common genetic weakness in the pilot study and if any correlated with the lab results

Presenter: Monika Buerger, BA, DC

Title of Talk: The Vagus Nerve Paradox

Abstract:

This lecture will focus on Vagus Nerve afferent input into the brain from the viscera, particularly the microbiome, and its effects on interoceptive (sensory) modulation, social behavior, digestion, and immune modulation in the neurodiverse population. Understanding heart rate variability and vagal tone will be addressed, as will various management strategies to modulate vagal tone.

Objectives

• To help attendees understand the role the Vagus Nerve plays in common co-morbidities in neurodiverse populations
• To help attendees understand heart rate variability and its meaning
• To help attendees gain protocols for Vagal Tone modulation

Presenter: Jill Crista, ND

Title of Talk: An Unlikely Hero to Address POTS, Dysautonomia, MCAS, and EDS

Abstract:

Dr. Jill Crista presents a groundbreaking therapy for long Covid and spike protein-related issues using an unexpected hero: nicotine. This innovative approach targets the ⍺7-nicotinic acetylcholine receptors, where spike proteins can bind and cause various neurological, mast cell, and collagen-related symptoms. Patients have experienced significant improvements, ranging from complete remission of long Covid symptoms in just days, and relief of dysautonomia, POTS, MCAS, and EDS symptoms in weeks. As a recipient of this cutting-edge information, you will be equipped with a powerful tool to transform the lives of those suffering in the post-Covid era, backed by scientific research and Dr. Crista's own clinical experience.

Objectives

• Describe the overlooked Covid receptor and its role in autonomic nervous system regulation.
• Make the connection between proteins found on the spike protein and the PENTAD syndromes: dysautonomia, POTS, MCAS, gastroparesis, and EDS.
• Share detailed nicotine protocols, including how to administer this innovative treatment safely, and with children, including how to manage potential addiction/tolerance.

Presenter: David Dornfeld DO

Title of Talk: I can submit a couple of cases if that’s what you’d like or I can offer lecture “Combining safety, detoxification and hyperbaric to help heal Yourself and your child.

Abstract:

I can speak on a variety of topics in regard to elation therapy, mold, detoxification, disease, and hyperbaric and creating better outcomes for your child Spectrum and for the families

Objectives

• Understanding a better assessment for heavy-metal detoxification.
• How to probably use various chelating agents.
• Why hyperbaric therapies can argument your child’s improvements.
• How to evaluate your home properly for Mold and support the people within it

Presenter: Cathy Meehan, owner of MeehanMD and MINDSETkids

Title of Talk: What is a MINDSETkid?

Abstract:

What is a MINDSETkid?

Welcome to MINDSETkids, a holistic care clinic that redefines pediatric health by emphasizing natural, integrative, and preventative care. Our approach is designed to empower parents with the knowledge, tools, and support they need to make informed healthcare decisions for their children—decisions that prioritize long-term well-being over quick fixes and unnecessary medical interventions.

At the core of MINDSETkids is the acronym MINDSET, representing key pillars of holistic health:

M: Microbiome – We focus on maintaining a healthy gut, which is foundational to overall health and immunity.

I: Inflammation – We aim to reduce chronic inflammation, which is linked to many modern health issues, including autoimmune disorders.

N: Nutrition – Proper nutrition is critical for growth, development, and disease prevention.

D: Detoxification – We support the body’s natural detox processes to eliminate harmful toxins from food, the environment, and more.

S: Sleep – Adequate sleep is vital for cognitive development, emotional well-being, and immune function.

E: Exercise – Physical activity is key to promoting a healthy mind and body.

T: Total Hormone Balance – Balancing hormones is essential for mood regulation, energy levels, and overall health.

Saying Goodbye to Mainstream Pediatric Clinics

Mainstream pediatric clinics often offer a one-size-fits-all approach that doesn’t address the individual needs of every child. Many of these clinics promote standardized treatments without providing full transparency or informed consent, especially when it comes to vaccines, pharmaceuticals, and other interventions that may carry risks.

At MINDSETkids, we say goodbye to this outdated model. We advocate for personalized care that looks at the child as a whole, not just isolated symptoms. Our mission is to put the power of healthcare decisions back into the hands of parents, where it belongs. We believe that knowledge is power, and by educating parents on alternative therapies, natural remedies, and preventative strategies, we are helping families make the best choices for their children's health.

Our Holistic Approach

MINDSETkids offers a comprehensive array of resources, including:

Educational Tools and Resources: Our website and resource membership club provide an abundance of wellness information, interactive webinars with health professionals, and access to a community of like-minded parents.

Holistic Medical Care: Our clinic is staffed by a diverse team of doctors, including MDs and DOs, with expertise in family medicine, pediatrics, and emergency medicine. Each provider has extensive experience working with children and shares a commitment to promoting natural healing and optimal functionality.

We don’t just focus on treating illnesses but on preventing them through proactive healthcare measures that align with how our bodies are designed to function. Our team is also supported by a distinguished advisory board, offering additional pediatric guidance to ensure that every child receives the best care possible.

Partnership with MAPS Doctors

We are seeking a relationship to work closely with MAPS (Medical Academy of Pediatric Special Needs) doctors to ensure that children with complex medical needs, such as those with autism spectrum disorder (ASD) or chronic illnesses, receive specialized care. When MINDSETkids encounters requests for these special patients, we want to direct them to a local brick and mortar MAPS provider in their home state, reducing the need for long-distance travel and providing continuity of care.

MINDSETkids also wants to free up your time by providing an additional marketing avenue where we do the promoting and then send you the patients who require expertise. These referred patients become exclusively yours to manage, creating a seamless partnership that benefits both practitioners and families.

The cost to patients for the MINDSETkids telehealth is a nominal $24.99/month which covers common ailments and free sick visits. For MAPS physicians and providers who are accepting referrals for special needs, they can charge there regular and standard fees since these patients will become a patient of their clinic or practice.

Conclusion

MINDSETkids is more than just a clinic; it's a movement toward empowering parents to take control of their children's health. By focusing on the pillars of the MINDSET framework—Microbiome, Inflammation, Nutrition, Detoxification, Sleep, Exercise, and Total Hormone Balance—we aim to foster a generation of healthy, thriving children. With MINDSETkids, parents can say goodbye to the constraints of mainstream pediatric care and hello to a holistic approach that puts their children’s well-being first.

Let’s work together to create healthier futures for our children—because every child deserves the best start in life.

Objectives

• Understand the MINDSET Framework: Participants will be able to identify and explain the seven pillars of the MINDSET acronym—Microbiome, Inflammation, Nutrition, Detoxification, Sleep, Exercise, and Total Hormone Balance—and their importance in promoting holistic health in children.
• Recognize the Limitations of Mainstream Pediatric Care: Attendees will be able to evaluate the differences between conventional pediatric care and the integrative, natural approach provided by MINDSETkids, emphasizing the need for informed consent and personalized healthcare for children.
• Learn How together we can shake up the standard broken pediatric model of healthcare and wellness visits: Attendees will learn how we gain the trust back from parents and how together we can keep kids out of the pediatricians office where parents are no longer in control of their children's health. Participants will gain knowledge of the resources available through the MINDSETkids program, including telehealth services, educational tools, and partnerships with MAPS doctors, and how these can be applied to improve their children’s health and well-being.

Presenter: Craig Shimasaki, PhD, MBA.

Title of Talk: How Common Infection Can Active CaMKII in Brain Cells Leading to Chronic Neuropsychiatric Symptoms: Case Studies and Resolution

Abstract:

CaMKII is a key enzyme in brain cells and plays an essential role in neuroplasticity and cognitive function is responsible for the regulation of several neurotransmitters in the brain. When activated CaMKII modulates the release of neurotransmitters: dopamine, norepinephrine, glutamate, GABA, serotonin, and acetylcholine in the brain.

Studies suggest that CaMKII dysfunction throughout the brain may underlie myriad neuropsychiatric disorders, including drug addiction, schizophrenia, depression, epilepsy, and multiple neurodevelopmental disorders, perhaps through maladaptations in glutamate signaling and neuroplasticity.

58 patients were enrolled in this retrospective study who were diagnosed with immune-mediated neuropsychiatric disorders or presumed to be based upon workup. Their antineuronal antibodies and CaMKII activation levels were measured before and after treatment, and their symptoms were assessed for improvement, resolution, or worsening. Autoantibodies from PANDAS/PANS and Sydenham chorea patients stimulate activation of CaMKII in human neuronal cells. It was observed that there was a strong correlation between the presence or absence of symptomology with the activation or lack of activation of the CaMKII enzyme in human neuronal cells.

The evidence from our research points to a possible new target for the diagnosis and treatment of patients who experience infection-induced, immune-mediated neuropsychiatric disorders. The clinical application may be a new target for therapy for patients experiencing infection-induced, immune-mediated neuropsychiatric disorders. It may also result in another biological mechanism that may help in understanding the pathophysiology of chronic infection-triggered and tick-bone disorders that manifest neuropsychiatric symptoms.

Objectives

• Understand the biological mechanism and role that CaMKII plays in neurodevelopment, neuroplasticity, and brain activity.
• Understand clinical manifestations in which various infections can cause immune dysregulation, leading to the stimulation of CaMKII in human neuronal cells and the interference of normal brain function by antineuronal antibodies.
• Identify specific symptoms associated with activation of CaMKII in human brain cells and specific immune-modulatory, anti-inflammatory, and anti-infectives that can ameliorate these clinical symptoms in patients.

Presenter: Koichi Tanji, ND, LMHC, FMAPS

Title of Talk: Excessive Gaming, Neurological Health, and Psychosis: Examining Dopaminergic Dysregulation, Motor Skills Impairment, and Mental Health Risks

Abstract:

The increasing prevalence of excessive gaming has been shown to have detrimental effects on both mental and neurological health. While the connection between gaming addiction and conditions such as schizophrenia and psychosis has garnered significant attention, there is also growing evidence that excessive gaming negatively impacts fine motor skills and neurological function. This presentation will explore the multifaceted consequences of excessive gaming, with a focus on the interplay between dopaminergic dysregulation, psychotic symptoms, and neurological impairment.

We will discuss the evidence linking excessive gaming to dopamine receptor desensitization, which contributes to the development of psychosis in susceptible individuals. Additionally, the presentation will highlight how excessive screen time, particularly in immersive and repetitive gaming environments, can lead to fine motor skill deterioration and poor hand-eye coordination. These cognitive and motor impairments, combined with the effects of social isolation and sleep deprivation, further exacerbate mental health issues such as anxiety, depression, and psychosis.

By reviewing recent research, clinical case studies, and neurobiological mechanisms, we will provide a comprehensive understanding of how excessive gaming can lead to neurological decline and psychotic episodes. This time, the presentation will focus on actionable, detailed strategies for healthcare providers, addressing early interventions and concrete management plans to tackle the risks of gaming-related neurological and mental health challenges.

Objectives

• Understand the Neurobiological Impact of Excessive Gaming: Attendees will explore how dopamine dysregulation and dopamine receptor desensitization are linked to the development of psychotic symptoms and broader mental health issues in individuals with excessive gaming habits.
• Recognize Neurological Impairments: Attendees will gain insight into how excessive gaming impairs fine motor skills, hand-eye coordination, and cognitive functioning, contributing to broader neurological decline and increased risk of psychosis.
• Develop Actionable, Detailed Intervention Plans: Attendees will learn practical and specific intervention strategies for identifying early signs of gaming-related mental health risks and neurological impairments, with a focus on individualized treatment and prevention plans that can be immediately implemented in clinical practice.

Presenter: Koichi Tanji, ND, LMHC, FMAPS

Title of Talk: Case Study: Gaming Addiction Mimicking Autism Spectrum Disorder (ASD)

Abstract:

Case Study: Gaming Addiction Mimicking Autism Spectrum Disorder (ASD)

Patient Profile:

Name: John (14-year-old male)

Initial Presentation:

School refusal for 3 years

Diagnosed with ASD (Autism Spectrum Disorder) and ADHD when he was 7 yo.

Struggling socially, with a history of bullying and social isolation

Severe emotional dysregulation and frequent tantrums

Picky eating, poor hygiene, and stereotypical behaviors resembling ASD

Unable to tie his shoelaces, exhibiting fine motor delays associated with ASD

Complaints of migraine and chronic abdominal pain, often used as excuses to avoid school and social situations

Developed video game addiction, spending excessive time immersed in gaming to avoid stressors

Displayed psychotic features: imaginary speech, often referencing a dark, creepy world, detachment from reality

Treatment Timeline:

Month 0-2: Initial Screen Addiction Treatment

The patient started a treatment protocol focused on screen addiction management.

Engaged in behavioral interventions targeting video game overuse, with a gradual reduction in screen time.

Within two months, John began attending school daily, although he remained socially withdrawn during class.

Month 2-6: Engaging with Support

Continued reduction of screen time, focusing on structured activities and social engagement.

Supportive interventions were implemented, including group therapy and counseling for emotional regulation.

By month six, John began engaging socially, with guided support from teachers and therapists.

Physical symptoms like migraine and abdominal pain started to decrease.

Month 6-10: Academic and Social Improvement

Significant improvement in academic performance, receiving A's and B's in school.

John's ability to tie shoelaces and perform other fine motor skills improved.

Psychotic symptoms resolved completely, and no further ASD features were observed. His speech normalized, and references to the imaginary world ceased.

Month 10-12: Physical Health and Social Breakthrough

John lost 30 lbs in a healthy manner and began participating in wrestling and track and field.

His self-esteem improved, and for the first time in his life, he started dating, an experience he never expected due to his previous struggles with social interaction.

Outcomes:

John’s initial diagnosis of ASD was reconsidered, with his symptoms believed to be largely driven by gaming addiction and social isolation.

After screen addiction treatment, he showed no signs of ASD, and his psychotic features resolved completely.

The success of the treatment resulted in significant improvements in academic performance, social engagement, and physical health.

Clinical Insights:

This case demonstrates how excessive screen time and gaming addiction can mimic symptoms of ASD, including social withdrawal, stereotypical behaviors, and psychotic features.

The patient's dramatic recovery after treatment suggests that in some cases, behaviors diagnosed as neurodevelopmental disorders can be symptoms of environmental factors like screen dependence.

Objectives

• Excessive gaming and screen addiction can lead to neuropsychiatric symptoms that resemble more permanent conditions such as ASD or psychosis.
• Early identification and treatment of screen dependence can lead to significant improvements in emotional regulation, social skills, and overall mental and physical health.
• The success of the treatment resulted in significant improvements in academic performance, social engagement, and physical health.

Presenter: Dr. Debby Hamilton, MD, MPH, IFMCP

Title of Talk: Do abnormal levels of Brain Derived Neurotrophic Factor (BDNF) play a role in the development of autism spectrum disorders, and can we regulate Brain Derived Neurotrophic Factor to help these children?

Abstract:

Brain Derived Neurotrophic Factor (BDNF) is a growth factor in the CNS that is involved in the growth, development, and differentiation of neurons, neurotransmitter modulation and ongoing synaptic development and neuroplasticity. This growth factor also exists in the digestive tract so plays a role in regulating the nervous system through the gut-brain axis. Therefore, normal levels of BDNF are critical for healthy brain development and growth in children. Herbs, lowering stress, exercise, and nutrition have been shown to increase levels of BDNF with associated increases in cognitive function though neuroplasticity. Diseases associated with neuroinflammation such as neurodegenerative diseases, mood disorders, and traumatic brain injuries have been shown in research to have decreased levels of BDNF.

In autism spectrum disorders there is also neuroinflammation so it would be predicted that BDNF levels would be decreased and improving these levels would help increase neuroplasticity and cognitive function in ASD. Yet, research has shown both lower and higher levels of BDNF in children with ASD and ADHD compared to neurotypical children. Examining the specifics of the research is important to understand how BDNF plays a role in the development of ASD from prenatal to adult development since this is a critical neurologic growth factor. BDNF is derived from proBDNF and each of these has a different receptor with only the BDNF receptor involved in neuronal growth. ProBDNF binds to a receptor that negatively impacts neuronal growth and differentiation. Research has shown that levels of proBDNF may be elevated in ASD when measurement of BDNF and proBDNF are differentiated. Concern about how accurate BDNF levels measured in the blood compared to BDNF levels in the CNS has been raised with some research showing an improvement in cognitive function, mood, and stress levels with herbs supporting BDNF but inconsistent BDNF blood levels. Understanding how BDNF is involved in healthy brain development, how this process may become disrupted and how to regulate and support healthy BDNF is important for the health of our children on the autism spectrum.

Objectives

• Understand how brain derived neurotrophic factor is involved in the development of the nervous system beginning prenatally.
• Understand the mechanisms involved in neuroplasticity ,which is how the brain can remodel and heal with a decrease in neuroinflammation.
• Discuss the review of the literature to better understand how abnormal levels, forms of BDNF, and receptor types are involved in ASD and ADHD and how we measure BDNF might not be an accurate test of true BDNF levels in the brain.
• Understand how to support healthy BDNF levels safely with herbs, adaptogens, exercise, and nutrition.

Presenter: Darrell SCS Misak, ND

Title of Talk: Energy, Chemistry, Food, Restoration. A Bio-Electric Diet Approach to Health Restoration.

Abstract:

INTRODUCTION:

Energy is life, and life is energy.  The first day of disease is when you consume more energy than you get from your food.  What if you could use a simple home analytical test to understand the chemical processes and patterns of health restoration? Reams’ analysis and a lifestyle determined by personal energy efficiency lays a blueprint for health restoration.  When you combine functional medical assessment with a quantum Bio- Electric understanding, the concept of “Nature Cure” becomes the observable results of daily practice. 

DESCRIPTION:

Tesla stated, “if you want to understand the universe, you must think in concepts of energy and vibration.”  Einstein mathematically showed that Energy is Matter (E=Mc 2 ) which relatively affects each other.  Dr. Carey Reams mathematically showed that Energy and Matter are composed of heat and electricity, while the Law of Thermodynamics explains Energy is neither created nor destroyed but only transferred.  Combining these concepts, the total load theory supports and gives understanding that body burdens affect the body’s efficiency to restore, laying the foundations that all disease relates to body deficiencies or excesses. If you learn the chemistry of energy efficiency, you are empowered with a cause-and-effect blueprint of health that outlines basic mineral and vitamin deficiencies that explain patterns of “disease.”

RESULT:

Homeostasis states everyone is as healthy as they can be, based on the ability of their cells to adapt to the energetic and cellular stress they undergo, along with the elemental building blocks they have to work with.  A quantum Bio-Electric concept of health with understanding the complexity of what a Reams’ analysis offers shows a reproducible pattern of health restoration, where auto-immune, cancer, metabolic, neurodegenerative brain and hormonal disorders can be explained and modified through a simple understanding of lifestyle changes to minimize body burdens along with repletion of vitamin and mineral deficiencies.

CONCLUSION:

Considering innovation and an outline to the historical concept of Nature Cure, a lifestyle understanding incorporating a quantum bio-electric chemistry approach becomes self-evident to explain restorative health; you must generate more energy than you consume.  The concepts of Reams’ Biological Theory of Ionization, along with the ability to identify chemistry, vitamin deficiencies, signs of environmental excesses, and observe a functional biological process of health restoration has never been elucidated in the modern functional medicine paradigm, nor explored in modern medical research. The goal of this presentation is to open the mind and exploratory practices of naturopathic medicine to challenge, then prove or disprove how these concepts outline and restore the concept of Nature Cure and a Bio-Electric Terrain of what constitutes health.

Objectives

• Introduce innovative Bio-Electric analytical and diet concepts
• Stimulate critical thinking how an analytical Bio-Electric Approach can explain functional disease patterns
• Show case study of practical application of Bio-Electric concepts

Presenter: Taron Fletcher, B.Sc.

Title of Talk: Mood stabilization with a broad-spectrum vitamin and mineral formulation.

Abstract:

Broad-spectrum micronutrient supplements were studied in five double-blind randomized controlled trials Between 2000 – 2016. These five different products were evaluated in anti-social behavior, personality difficulties, aggression, and conduct violations in disadvantaged preadolescent, adolescent, and young adults in public schools and incarcerated populations; the results were comparable (brief summary with references 1-5).

During this same timeframe independent research was being conducted on the broad-spectrum micronutrient formulation that would come to be known as Hardy Nutritionals® Daily Essential Nutrients™. Initial research was more narrowly focused on mood lability namely bipolar symptoms but also with comparable outcomes. The similarity to the above noted interventions was also a broad spectrum; the differences were in completeness and dose (brief summary of select clinical trials with references 6-14).

Using the Dietary Reference Intakes from the National Academy of Medicine (NAM), we will examine the evidence surrounding essential nutrient dosing. Additionally, using evidence from the Kyoto Encyclopedia of Genes and Genomes (KEGG) mapping project we will explore the rationale and mechanisms for a broad-spectrum intervention in mood and behavior modification (references 15-21).

Objectives

• Recognize the broad-spectrum micronutrient benefit for mood and behavior modification.
• Understand why single nutrients may be ineffective.
• Understand why you want to exceed the RDA.
• Understand how broad-spectrum micronutrients can help you eliminate root nutritional symptoms before addressing additional symptoms.

Presenter: David Socol MD.

Title of Talk: Pediatric Trauma & Special Operators: When Hindsight is 20/15

Abstract:

The downstream risks associated with subclinical traumatic brain injury are frequently underappreciated by the victim and their healthcare provider. Using a lessons-learned approach from civilian and military communities, this presentation intends to encapsulate the potential influence of subclinical traumatic brain injuries in childhood on the risk of psychiatric, neurodegenerative and cardiovascular disease in adults, regardless of family history, using a systems-based pathophysiological model. An active surveillance rubric for those with subclinical traumatic brain injury emerges within this framework, which may be enhanced in the presence of functional genomics. The pathophysiological rationale for provider intervention in the absence of clinical symptoms will also be contemplated, as will evidence-based interventional options that are largely unconstrained by the socioeconomics of the victim and/or their family and the toolsets generally available to the community healthcare provider.

Objectives

• Recognize the broad-spectrum micronutrient benefit for mood and behavior modification.
• Understand why single nutrients may be ineffective.
• Understand why you want to exceed the RDA.
• Understand how broad-spectrum micronutrients can help you eliminate root nutritional symptoms before addressing additional symptoms.

Presenter: Melanie Alarcio, MD (H)

Title of Talk: MCAS and NeuroInflammation and its role in Neuropsychiatric Disorders

Abstract:

Mast cells are important components of the innate and adaptive immune system and participate in all stages of the inflammatory response and may contribute to neuroinflammation associated with neurologic and neurodevelopmental/neuropsychiatric disorders like Parkinson’s disease, depression, schizophrenia, autism spectrum disorder, PANS/PANDAS, to name a few. Addressing mast-cell induced neuroinflammation may help improve outcome of these disorders

Objectives

• To understand the role of mast cells in the neuroinflammatory response
• To understand how mast cells can affect the pathogenesis of neurologic/psychiatric disorders
• To look deeper into some therapeutic aspects of addressing mast cell activation

Presenter: Dr. Somer DelSignore, BC-PNP, DNP

Title of Talk: Could Tick-borne Autoimmune Encephalopathy Manifest as Autism Spectrum Disorder

Abstract:

Autism Spectrum Disorder (ASD) is a neuro-developmental disorder that presents with atypical social interactions and communication, OCD, mood dysregulation, impulsivity, rigidity, rumination, sensory dysfunction and other neuro-cognitive, Neuro-psychiatric dysfunction. Data from a 2020 survey estimates 1:36 children currently carry the diagnosis. Additionally, Infection and immune-mediated/autoimmune disorders in the mother are known risk factors that increase the chances of a child developing ASD. These inflammatory factors as well as altered maternal microbiota may be contributing to increased inflammatory cytokines and/or autoantibodies that react to fetal brain tissue.

These factors alter the immune profile and neurodevelopment of the child and are linked to behavioral abnormalities seen in ASD including repetitive behaviors, stereotypes, anxiety, and impaired social behaviors. Interestingly, autoimmune encephalopathy (AE) is an autoimmune response triggered by maternal, environmental and/or infection with overlapping symptom to that of ASD.

Strong evidence of an autoimmune responses after an infectious agent or environmental exposure are linked to Autism Spectrum Disorder. A 2018 study found more children with autism also had history of encephalitis compared with neurotypical children (Hughes, et al.). Also, maternal immune activation contributed to higher risk of immune dysfunction and neuroinflammation typical of both ASD and AE.

Babesia and other Tickborne diseases are a multi-system infection and can cause central and peripheral nervous system dysfunction.It can be challenging to differentiate between neurologic disease and other disorders affecting behavior. Understanding all behavior requires a properly functioning nervous system.

This presentation will explore and link neurocognitive and neuropsychiatric conditions commonly found in Autism Spectrum Disorder and Autoimmune Encephalopathy.

Neurocognitive and neuropsychiatric conditions are thought to be fundamentally neurobiological, and presumably attributable to problems with neurotransmission, network dysfunction , and in some cases, learned behaviors. This presentation will discuss biological distinction between typical neurologic disease and the autoimmune pathway as well as discuss treatment response through case study presentation.

Objectives

• Review pathophysiology and mode of Tickborne disease transmission in children.
• Discuss neurobiology of autoimmune pathway effects upon cognition, processing and neuropsychology.
• Explore overlapping symptoms of Infectious Triggered Autoimmune Encephalopathy and Autism Spectrum Disorder
• Examine treatment modalities and the impact upon neurological status of children diagnosed with Autism Spectrum Disorder and Autoimmune Encephalopathy.
• Present and discuss Pediatric Cases for clinical gains.

Presenter: Dr. J. Jay Gargus

Title of Talk: Unlocking Familial Insights: Exploring the 10-20x Increase in Autism Risk Among Newborn Siblings in ASD Families

Abstract:

In this lecture, Dr. J. Jay Gargus, the Chief Scientific Officer and Scientific Founder of NeuroQure, will present on the significantly increased autism risk among newborn siblings in families with ASD. Dr. Gargus will explore the factors driving this heightened risk and introduce NeuroQure's innovative testing technologies that can identify autism risk as early as two days after birth. The presentation will emphasize the transformative potential of early detection and timely interventions in improving developmental outcomes. Physicians will gain valuable insights into managing familial ASD risk and utilizing cutting-edge tools for early and personalized care.

Objectives

• Understand the genetic and environmental factors contributing to autism risk in ASD families
• Explore early ASD risk detection and learn how new technologies can assist in doing so
• Enhance patient outcomes through earlier intervention - all before the national average age of ASD diagnosis

Presenter: Dr. Lynda Dean-Duru

Title of Talk: Beyond First Latch: The Role of Dentists in Ensuring Proper Growth of the Craniofacial-Respiratory Complex from Infancy

Abstract:

Craniofacial and respiratory development are intertwined with a child's neurological health. From the moment of birth, the head and face experience natural compressive forces—a necessary adaptation to pass through the birth canal. However, this process, compounded by modern birth practices, epigenetic changes, and structural constraints, results in cranial dysfunctions in virtually all newborns. While these dysfunctions are a natural response, they require proper functional input—such as breastfeeding, nasal breathing, and other physiological movements—to resolve and prevent future complications. An optimal suck-swallow-breathe reflex lays the foundations for correct neurological development as the infant grows. This abstract explores how pediatric dentists, using integrative techniques like the ALF (Advanced Light Force) approach, cranial osteopathy, and functional frenuloplasty, can play a key role in promoting long-term craniofacial and neurological health.

Universal Cranial Dysfunctions and Their Impact: At birth, the skull’s natural compression is nature’s solution to the challenge of fitting a large head through a small birth canal. These cranial dysfunctions, while common, can have lasting consequences if not corrected through the natural actions of optimal breastfeeding, correct swallowing, nasal breathing, and chewing. These functions serve as therapeutic interventions for the newborn, promoting proper craniofacial growth and preventing structural misalignments that could otherwise lead to more significant developmental issues.

Without the benefits of these natural functions, children are more prone to developing conditions such as sleep-disordered breathing, attention difficulties, and behavioral problems. The rise in ADHD diagnoses is a clear indication of this. In fact, 78% of children diagnosed with ADHD also have co-occurring conditions such as anxiety, developmental delays, and behavioral disorders. Studies, including those by Jessica Nye, PhD (March 2024), reveal a high prevalence of sleep-disordered breathing in children with ADHD. Furthermore, research by Carmen Berenguer et al. shows that sleep problems mediate the relationship between ADHD symptoms and communication difficulties, exacerbating these challenges.

The Role of Pediatric Dentists in Early Intervention: Pediatric dentists are uniquely positioned to detect and intervene in these craniofacial dysfunctions from infancy. Techniques such as ALF therapy, developed by Dr. Darick Nordstrom, and cranial osteopathy address the root causes of these dysfunctions by optimizing cranial nerve function, restoring proper alignment, and enhancing overall facial growth. Functional frenuloplasty further helps release tethered oral tissues, ensuring that the tongue performs its vital role in breastfeeding, nasal breathing, and craniofacial development.

These interventions, combined with innovative therapies like BabyLase™ and neuromuscular re-education, help ensure that infants' natural functions—sucking, swallowing, and breathing—are functioning optimally, promoting healthy facial growth and minimizing the risk of future developmental disorders.

Connection to ADHD and Sleep Disorders: Craniofacial dysfunctions that go unresolved in infancy can manifest as sleep-disordered breathing and contribute to developmental conditions like ADHD. Sleep, a critical factor in neurological and cognitive development, plays a central role in children’s ability to focus, communicate, and behave appropriately. The cross-prevalence of ADHD and sleep-related disorders emphasizes the need for early dental interventions that target these foundational issues. By addressing these dysfunctions early, pediatric dentists can help mitigate the indirect effects on communication, attention, and behavior, as noted in Berenguer’s study.

Case Studies:

Infant XH: A child with persistent open mouth posture showed significant improvements in lip closure and overall craniofacial growth following BabyLase therapy, osteopathy, and conservative functional frenuloplasty.

Infant LK: A 15-month-old with moderate sleep apnea and persistent tongue protrusion experienced notable improvement in both craniofacial development and sleep patterns after a multidisciplinary approach involving cranial therapy and oral appliances.

The C.A.R.E. Approach: At Ashburn Children’s Dentistry and Womb 2 Grow Wellness, we have developed the C.A.R.E. approach, which stands for Comprehensive Assessments, Advanced Therapies, Responsive Care, and Education. This approach allows us to assess and treat children’s craniofacial dysfunctions early, addressing the root causes and preventing long-term developmental issues. Pediatric dentists, as part of a collaborative care team, work closely with healthcare providers such as lactation consultants, cranial osteopaths, pediatricians, and myofunctional therapists to ensure holistic and integrative care for the child.

Conclusion:

Craniofacial dysfunctions at birth are nearly universal, and without proper functional therapy, they can lead to significant developmental disorders, including ADHD and sleep-disordered breathing. Pediatric dentists have a critical role in early detection and intervention, using integrative techniques to restore proper function and promote optimal craniofacial growth. By addressing these issues early, dentists can significantly improve long-term neurological and developmental outcomes for children.

Objectives

• Identify the Role of Natural Birth Processes in Craniofacial Development: Attendees will learn how the natural compressive forces during birth, combined with modern birth practices, can lead to cranial dysfunctions in newborns, and how early detection and intervention can support optimal craniofacial and neurological development.
• Recognize the Importance of Functional Therapies in Resolving Cranial Dysfunction: Participants will explore how functional activities such as breastfeeding, proper swallowing, nasal breathing, and chewing act as natural therapies that promote healthy craniofacial growth and prevent long-term developmental issues.
• Implement a Collaborative Care Approach for Early Intervention: Attendees will understand how pediatric dentists, as part of a multidisciplinary team, can use integrative therapies like ALF, cranial osteopathy, and functional frenuloplasty to treat cranial dysfunctions and improve long-term outcomes for children with developmental and neurological challenges.

Presenter: Dr. Victoria Kobliner MS RDN

Title of Talk: NUTRITIONAL MODULATION of EPIGENETICS, INFLAMMATION, and MITOCHONDRIAL, GUT and METABOLIC FUNCTION in PEDIATRIC NEUROLOGIC HEALTH

Abstract:

Substantial evidence confirms that appropriate nutrition plays an important role in prevention and remediation of neurologic impacts in a variety of pathological neuropsychiatric conditions. Dietary factors are important mechanisms influencing neurotransmitter function, neuroinflammation, methylation, mitochondrial dysfunction, and epigenetic modulation. These include vitamins, minerals, amino acids, polyphenols, butyrate, and pre/pro and postbiotics. Optimizing therapeutic nutrition interventions (including restrictions and additions to diet), digestive function, and nutritional supplementation can play a foundational role in supporting pediatric neurologic syndromes by modulating metabolic control, epigenetics, mitochondrial, inflammatory pathways and gut-brain axis.

Objectives

• Name 5 key dietary factors that impact neurologic function
• Identify 3 areas where epigenetic modulation can affect neuroinflammation
• Understand the role of plant-based compounds in improving gut health

Presenter: Casey Kelley, MD

Title of Talk: Lyme and the Pediatric Brain

Abstract:

Lyme Disease in children can often go overlooked and undiagnosed, especially when the presenting symptoms are not the typical bullseye rash and joint swelling. Pediatric neurological symptoms can range from new onset lack of focus, tic disorders, seizures, headaches, mood and behavior changes to severe PANS. To add to that, sometimes other VBD can be a bigger driver of symptoms (inluding bartonella and babesia). In this talk I will lay out the groundwork to diagnose kids with Lyme and tick-borne infections and how to treat their neurological symptoms using medications, herbs and supportive supplements.

Examples include:

• Medications include augmentin, cephalosporins, doxycycline, Bactrim, mepron
• Herbs include: cats claw, Japanese knotweed, skullcap, artemisinin, oregano
• Symptom: Behavior/defiance: lithium, skullcap, probiotics
• Symptom: Anxiety/OCD/depression: b vitamins, NAC, theanine, probiotics
• Symptom: Inattention: b vitamins, phosphatidylcholine
• Symptom: Headaches: glutathione, hydrogen, phosphatidylcholine, fish oil

Objectives

• Understand how VBD can present in kids neurologically
• Gain tools to support a diagnosis of VBD
• Learn ways to start treating these infections with medications, herbs and supportive supplements.

Presenter: Star Edwards, MS, RDN/LD

Title of Talk: Microbial Functions: The New Frontier of Microbiome Testing

Abstract:

The focus of early microbiome research was to identify and describe the composition of microbes in the microbiome. While knowing who is in the microbiome matters, knowing what these microbes do, however, matters more.

In recent years, microbiome research has reached for a deeper understanding of the mechanisms of action and functional insights of the microbiome in an effort to better identify the impact of the microbiome on human health and disease. While early technology did not have the capabilities to identify functional genes of the microbiome, the emergence of newer technology, such as shotgun metagenomics, is advancing this new frontier of functional analysis.

Functions of the microbiome, such as the production of ammonia, hydrogen sulfide, hexa-LPS, and short-chain fatty acids, impact extraintestinal organs such as the brain and liver through the gut-organ axes. Functions may provide insight into patient conditions and help drive therapeutic recommendations more efficiently than taxonomic categorization of microbes in the microbiome alone.

This presentation will discuss:

• Difference between identifying microbes taxonomically and functionally.
• Importance of microbial functions.
• Overview of common functions like Hexa-LPS, SCFA, and Hydrogen Sulfide production, and their role in the gut-organ axis, highlighting the gut-brain axis and neurodivergence.
• Using functions to drive therapeutic protocols.
• Utilizing shotgun technology to assess functions of microbes.
• Accuracy of shotgun metagenomics
• Unraveling the mystery of why every microbiome test yields different results (and what to do about it)

Objectives

• Describe the benefits of measuring functions in the gut microbiome.
• Describe the impact of specific functions on gastrointestinal symptoms and the gut-brain axis.
• List therapeutic interventions for symptoms related to microbial functions.

Presenter: Sabine Hazan, MD, Gastroenterologist

Title of Talk: Autism and the Gut Microbiome

Abstract:

Background.

In the United States, the prevalence of Autism Spectrum Disorder (ASD) is approximately 1 in 44 children aged 8 years. Modulation of the gut microbiome is emerging as a potential therapeutic option to manage and alleviate symptoms of ASD. Our case report study on a nineteen-year-old adolescent with severe ASD, showed that familial fecal microbiota transplantation (FMT) helped improved not only gut microbiome composition but also ASD clinical symptoms. Herein, we compared the gut microbiome of ASD patients with their healthy sibling and with non-familial healthy controls, to determine whether dysbiosis is associated with ASD1.

Methods.

Fecal samples from 21 ASD patients (ages 0-10 years old), 23 healthy siblings and 6 non-familial healthy controls were collected at ProgenaBiome laboratories. Microbiota composition was compared using DNA quantification, purification, and normalization using shotgun methodology and next-generation sequencing (NGS) on the Illumina NextSeq with 500/550 High-Output Kits V.2.5 for 300 cycles. Data were processed through the OneCodex bioinformatics system to determine microbiota composition and relative abundances of top genera and phyla. A two-sample t-test was used to evaluate statistical significance.

Results.

When we compared the gut microbiome between ASD patients and their siblings, ASD patients had lower abundance of Bifidobacterium (p < 0.006). Similarly, when compared to non-familial individuals, ASD patients had statistically significant lower abundance of Bifidobacterium (p < 0.001). At the species level, ASD patients had a similar gut microbiome diversity, as indicated by the Shannon Index, compared to their siblings (p = 0.348).

Conclusions.

These data suggest that gut dysbiosis is associated with ASD. Future research is needed to confirm these findings. However, if confirmed, ASD patients may be treated with FMT for dysbiosis to improve ASD symptoms.

Objectives

• Autism disease presents with gut dysbiosis symptoms.
• Some gut bacteria are associated with worse AD symptoms.
• Fecal microbiota transplant in autistic patients may alleviate autism symptoms.

Presenter: Eboni Cornish, MD

Title of Talk: Basal Ganglia Encephalitis and PANDAS: Insights from SPECT Imaging in Neuroinflammatory Disorders

Abstract:

Basal Ganglia encephalitis and Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections (PANDAS) represent neuroinflammatory conditions often linked to autoimmune triggers, affecting the neuropsychiatric and motor functions of pediatric patients. Standard neuroimaging modalities like MRI and CT often fail to capture the functional changes seen in these disorders, necessitating the use of more sensitive tools such as SPECT (Single Photon Emission Computed Tomography) scanning.

Objective:

To highlight the utility of SPECT scan imaging in identifying functional abnormalities in the basal ganglia in patients with Basal Ganglia encephalitis and PANDAS and provide actionable teaching points for clinical application.

Methods:

We conducted a retrospective review of pediatric patients diagnosed with PANDAS or Basal Ganglia encephalitis, evaluating the clinical course and neuropsychiatric symptoms alongside SPECT imaging findings. Patients were analyzed for changes in regional cerebral blood flow, particularly in the basal ganglia and associated neurocircuits.

Objectives

Teaching Points:

• SPECT as a Diagnostic Tool: While structural imaging may be unremarkable, SPECT can detect functional abnormalities in the basal ganglia in patients with neuropsychiatric disorders like PANDAS and Basal Ganglia encephalitis, offering crucial insights for diagnosis.
• Correlation with Clinical Presentation: Abnormal SPECT patterns in the basal ganglia correlate strongly with the neuropsychiatric and motor symptoms of PANDAS, providing a functional neurobiological basis for these symptoms.
• Tracking Disease Progression and Treatment Response: SPECT imaging is useful not only for diagnosis but also for monitoring disease progression and therapeutic response, particularly after immunomodulatory treatments like IVIG or antibiotics.
• Early Intervention: Recognizing SPECT findings early in the disease course may guide timely therapeutic interventions, potentially improving outcomes in patients with PANDAS and basal ganglia encephalitis.
• Multidisciplinary Approach: The integration of SPECT findings with clinical and neuropsychiatric assessments reinforces the need for a multidisciplinary approach in managing complex neuroinflammatory disorders.

Presenter: Lawrence B Palevsky, MD

Title of Talk: Child Development: Before We Lowered the Bar

Abstract:

Child Development: Before We Lowered the Bar

In 2022, how did the pediatric world allow the CDC to say that crawling is not an important motor developmental milestone in children? It is no longer possible to even find crawling as a milestone of motor development in children anywhere on the CDC website. When did rolling from tummy to back become a six month milestone of motor development, and moving things from one hand to another hand become a 9 month milestone? Pincer grasp seems to no longer be a 9 month milestone, now, it’s a 12 month achievement. According to the CDC, normal motor development for twelve month olds is walking holding onto furniture and starting to pull up to stand, while taking few independent steps isn’t expected until 15 months. It isn’t until 18 months that children who walk without holding on to anyone or anything are deemed to have normal physical development. Pointing and clapping are now developmental milestones for 15 month olds, who are also expected to say 1 or 2 words besides mama or dada. Language jumps to 3 or more words besides mama or dada by eighteen months, while children at this age are only expected to follow one-step directions, and are only now expected to feed themselves with their fingers. Since 2022, children are expected to only have 50 words by 2.5 years old (previously expected at 2 years old), but be able to put 2 words together by 2 years-old with fewer than 50 words.

As a physician who went to medical school from 1983-1987, and did a 3-year pediatric residency from 1987-1990, and a 1-year fellowship in the pediatric outpatient department from 1990-1991, I learned a very different set of pediatric developmental milestones. What has happened? Did normal childhood development change? Were we wrong decades ago when we described normal childhood development, and only now have a handle on what normal pediatric development looks like? I don’t think so.

It appears to me that because we have so many more children with developmental delays (1 in 5 children today has some form of neurodevelopmental delay ), we have had to lower the bar on what is acceptable achievement of pediatric milestones just so it looks like fewer children are delayed. Our children deserve better. In this lecture, I will review the real, normal childhood development before the bar was lowered, and compare it to what is generally accepted as normal in today’s pediatric world. I will explain how childhood brain development occurs, and what has been happening over the last four decades to compromise our children’s brain development.

Objectives

• Attendees will be able to learn the real, normal pediatric developmental milestones before the bar was lowered.
• Attendees will be able to compare normal pediatric developmental milestones with what we have accepted as normal pediatric development, today.
• Attendees will hear about how children’s brains develop, and what has compromised normal children’s brain development throughout the years.
• Attendees will hopefully use the real, normal pediatric developmental milestones in their offices to assess their pediatric patients and not rely on current guidelines, so they can catch any delays early enough, before the children are lost.

Presenter: Lawrence B Palevsky, MD

Title of Talk: The History & Physical Presentation of the Child with Special Needs (Foundations)

Abstract:

The History & Physical Presentation of the Child with Special Needs

Most children with special needs present to the physician with a complex history and a number of important findings on physical exam. These children are often highly inflamed and in a predominant sympathetic/high adrenaline state.

Pre-pregnancy and pregnancy physical and emotional health issues of both parents can greatly impact the health of fetuses before they are even born. Perinatal and neonatal interventions add another layer of impact on the health of newborns. Knowing how infants and children are fed, what supplements they take, how often they get sick and what OTC and pharmaceutical medicines and injections they’ve taken, what kind of dental work they’ve had, where they live, where they’ve traveled, and how and where children sleep, will further contribute to their overall health and development. Rounding out the history is the evaluation of pediatric developmental milestones.

In this lecture, I will highlight a number of important issues in the history that will help the practitioner better assess the child with special needs. I will also identify some of the more important pieces of the history most often contributing to the high levels of inflammation and increased adrenaline, and use these pieces to streamline recommendations and further evaluation of these children.

The physical exam is also very telling in helping the practitioner evaluate and treat children with special needs. In this lecture, I will hyper-focus on a number of concerning pediatric physical findings in children with special needs, and explain what they indicate about the children’s health and well-being, and what can be done to improve any of these abnormal findings.

Objectives

• Attendees will learn to take a comprehensive history in children with special needs, and utilize this information to better guide their evaluation and recommendations.
• Attendees will learn to recognize important abnormal findings on the physical exams of children with special needs to better guide their understanding of what’s going on, and how this information can better guide their evaluation and recommendations.
• Attendees will ultimately learn how to identify contributors in the history to ongoing inflammation and high sympathetic states, especially as it relates to sleep, diet, and intestinal and airway function.
• Attendees will also learn how these contributors manifest in the physical exams of these children, and what recommendations they can make to help improve these children’s health.

Presenter: Amy Derksen, ND, FMAPS

Title of Talk: Laboratory Clues in the Management of Complex Childhood Disease

Abstract:

This is a summary of the insurance-based and also specialty labs available to help in the practitioner's detective work with a pediatric population. It is an overall review of blood labs to order and how they help, OAT and stool testing options, as well as when to dig deeper with genetics, mold testing, heavy metals, etc. Not groundbreaking new info, but a roadmap for the practitioner to know how to use tools available in a smart way that can change the course of treatment.

Objectives

• Upon completion, participant will be able to utilize lab data to gain insight into the underlying causes triggering symptoms in the pediatric population, including cognitive and behavioral concerns.
• Upon completion, participant will be able to understand how to interpret basic bloodwork related to mitochondrial and methylation concerns.
• Upon completion, participant will be able to order and interpret specialty labs such as urine organic acid tests and stool tests for customized protocols.
• utilizing labs to help provide optimal support in a pediatric practice (OAT, stool, bloodwork and how to interpret and take action on those results)

Presenter: Sharon Hausman-Cohen, MD, FAAFP, ABIHM

Title of Talk: The role of neuronal connectivity in ASD and ADHD.

Abstract:

Abstract:

Differences in neuronal connectivity and myelination contribute heavily to both ADHD and ASD. Many of the gene variants that increase both the risk of ADHD and ASD are in fact genes that contribute to brain connectivity and myelination. However, there is not just one ""connectivity"" pathway and different genomic issues with connectivity contribute to different characteristics in the children with these gene variants. A number of different connectivity and myelination pathways will be discussed as well as ways of potentially identifying and modulating these pathways.

Further Discussion:

For example, CNTNAP2 effects auditory processing and language differences without affecting hearing, COMT is associated with less prefrontal cortex connectivity and decreased connectivity in 17 other areas of the brain which leads to higher errors of omission, but higher dopamine and adrenaline which contributes to longer focus and high achievement but also higher startle reflex, anxiety and emotional regulation. ADGRL3 affects central nervous system development and thus is associated with an increased risk of ADHD even before age 7 as well as some ASD characteristics.

The role of various supplements and modalities that can be used for the above gene variants will be discussed as well as how they relate to improve brain connectivity. Citicoline and lactobacilli reuteri, neurofeedback, various minerals and other neurotropics will be discussed.

Because high dopamine impairs myelination and some of these SNPs also affect myelination the importance of proper myelination in ASD and ADHD will also be touched upon.

Objectives

• Understand the Role of Different Types of Neuronal Connection and Scaffolding in Speech, ASD and ADHD
• Be able to list 3 ways to address individuals who have low CNTNAP2 function with diet, supplements and probiotics
• Feel capable of talking about genomic variants with your patients and why genomic variants are not ""mutations""

Presenter: James Greenblatt, MD

Title of Talk: Nutritional Lithium for Irritability and Aggression in Children

Abstract:

Abstract:

Chronic irritability and aggression are symptoms of various pediatric mental illnesses with the potential to significantly hinder therapeutic progress. Research consistently demonstrates that untreated irritability and aggression are predictive of future anxiety, depression, and suicide risk, and are also prognostic of longer, more intensive psychiatric treatments as well as poorer patient outcomes.

Psychiatrists have pursued pharmacologic solutions such as mood stabilizers and antipsychotics. Risperidone, for example, a potent atypical antipsychotic, is both FDA-approved and indicated for the treatment of aggressive behaviors in children as young as five.

There might be a place for psychotropic medication in the treatment of aggression and mood instability, but these medications confer significant risk of side effects. Common side effects include headaches, weight gain, nausea, sedation, sleep dysfunction, tremors, and insulin resistance.

In this presentation, Dr. Greenblatt will introduce a well-studied biological model of Disruptive Behavior Disorders from a functional medicine standpoint, and discuss mechanisms through which specific nutritional, metabolic, and biochemical factors can elicit behavioral pathology. He will review scientific research supporting associations between discrete biological imbalances, nutritional deficiencies, and aggression / irritability, with a key focus on the established mood-stabilizing properties of lithium and powerful evidence of low-dose lithium’s clinical utility. Dr. Greenblatt will present clinical recommendations on the use of Lithium Orotate for the treatment of aggression and irritability in pediatric patients.

Objectives

• Discuss the potential long-term implications of untreated irritability and aggression in pediatric psychiatric patients.
• Elucidate the differences between pharmaceutical vs. nutritional (“low dose”) lithium.
• Identify two or more biological mechanisms through which lithium confers neuroprotection and/or mood stability.

Presenter: Dr. Jaban Moore, DC

Title of Talk: Uncovering the Hidden Causes of Behavioral Issues in Kids

Abstract:

Abstract:

Behavioral issues in children can often be symptoms of deeper, underlying conditions such as PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) and PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal Infections). These conditions involve sudden-onset OCD, anxiety, tics, and other behavioral changes triggered by infections or immune dysregulation. This lecture explores the complex mechanisms behind PANS/PANDAS, including how infections, inflammation, and immune responses can impact the brain and manifest as severe behavioral and psychiatric symptoms in children. Attendees will learn about the latest research, diagnostic approaches, and holistic treatment strategies that address the root causes, offering a pathway toward lasting relief and improved quality of life for affected children and their families

Objectives

• Understand the Underlying Mechanisms of PANS/PANDAS: Gain a comprehensive understanding of how infections, immune responses, and inflammation can trigger sudden-onset behavioral changes in children, leading to conditions like PANS and PANDAS.
• Identifying: Learn how to recognize the signs and symptoms of PANS/PANDAS
• Explore Holistic Treatment Strategies: Discover holistic options for managing PANS/PANDAS, including nutritional support, immune system regulation, and therapeutic interventions aimed at addressing the root causes for long-term improvement in children's behavior and health.

Presenter: James Neuenschwander, M.D., FMAPS

Title of Talk: Biochemical Basis Of The Integrative Approach

Abstract:

Neuroinflammation underlies many of the symptoms we see in our pediatric patients with chronic conditions. In this presentation, we will review the pathways that underlie that inflammation and why elements like the activated microglia are connected with some of the demyelinating and brain injury that seems to be prevalent in a subset of autism. We will also review how this process manifests on some of the functional testing that many of us are already doing. This presentation will introduce some of the newer methods for testing the biochemical fall out of neuroinflammation (such as detailed evaluation of membrane lipids), biochemical function, and methyl transferase activity) to make more obvious which of our patients have this process as part of their underlying syndrome. Finally, we will use that information to review some of the treatment protocols that can be implemented to help recover our patients.

Objectives

• Identify markers on commonly used functional testing and review their connection with the biochemistry of neuroinflammation.
• Review the role of the microglia, astrocytes, and oligodendrocytes in the formation and pathology of neuroinflammation
• Discuss newer testing available to help identify the patient that has neuroinflammation
• Review treatment options to quell neuroinflammation and potentially repair any damage that has been done

Presenter: Tom Moorcroft, DO, FMAPS

Title of Talk: Rewiring Minds: Exploring Psychedelics for Autism and Mental Health Transformation

Abstract:

Psychedelic research is transforming modern psychiatry, offering novel therapeutic avenues for conditions like post-traumatic stress disorder, major depressive disorder, and treatment-resistant depression. This lecture will explore the pharmacological foundations and therapeutic mechanisms of MDMA, psilocybin, and ketamine, highlighting their emerging use in autism spectrum disorder (ASD). Participants will gain insights into the potential of these substances to address emotional dysregulation, anxiety, and social challenges in ASD. While promising, these therapies also bring unique risks and ethical considerations that will be discussed to ensure safe, responsible application.

Presenter: Darin Ingles, ND

Title of Talk: Histamine Intolerance And Mast Cell Activation

Abstract:

Research suggests many kids with autism have increased mast cell activation, which can produce significant physical and neurological symptoms and impair language, mood, cognition and behavior. Some kids with ASD also have concomitant histamine intolerance, which may also contribute to their symptom picture. In this lecture, Dr. Ingels will discuss the difference between histamine intolerance and mast cell activation and best practices to manage both conditions. He will review medications and natural substances that inhibit mast cells, promote histamine tolerance and immune modulating therapies such as low dose allergy therapy and sublingual immunotherapy.

Presenter: Sue Swedo, MD

Title of Talk: PANDAS & PANS – From Controversy to Competent Clinical Care

Abstract:

The unique clinical characteristics of Pediatric Autoimmune Neuropsychiatric Disorder Associated with Streptococcal infections (PANDAS) were first identified more than three decades ago in a cohort of young children with unusually abrupt onset of obsessive-compulsive disorder (OCD) and tics following Group A streptococcal (GAS) infections. PANDAS was postulated to occur when the molecular mimicry of infecting GAS bacteria provokes production of antibodies that misrecognize basal ganglia antigens as foreign and incite a neuroinflammatory response manifesting as a constellation of neurologic, emotional, behavioral, and cognitive symptoms. Additional factors, such as T-cell activation, have also been shown to play a role, documenting that PANDAS is indeed a form of “Autoimmune Encephalopathy Secondary to Infectious Disease”. Although findings from clinical, translational and basic scientific research provide overwhelming evidence that PANDAS is a post-infectious neuroinflammatory disorder, the disorder remains characterized as “controversial”, negatively affecting clinical care of affected children. The presentation will review some of the most common questions fueling the controversy, as an introduction to discussing clinical presentation, diagnostic evaluation, treatment and management of PANDAS and PANS (Pediatric Acute-onset Neuropsychiatric Syndrome).

Objectives

• Participants will be able to identify the five criteria for the PANDAS subgroup and will hear examples of how these patients differ from others with childhood-onset obsessive compulsive disorder (OCD)
• The relationship of PANS (Pediatric Acute-onset Neuropsychiatric Syndrome) to PANDAS will be discussed, and draft diagnostic criteria for PANS will be presented.
• Participants will be able to list the diagnostic tests that are useful in evaluating acute-onset OCD.
• Treatment guidelines for PANS/PANDAS will be presented and participants will be informed of on- line resources for case management.